Selective Estrogen Receptor Modulators (SERMs) - A Potential New Treatment For Women Of Child-bearing Age With Psychotic Symptoms Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$210,480.00
Summary
Schizophrenia is a devastating illness urgently requiring a new treatment approach. We have discovered that estrogen is an effective treatment for women with schizophrenia and are currently trialling a safer Selective Estrogen Receptor Modulator (SERM) known as brain estrogen� in postmenopausal women with schizophrenia. Regulatory permission is now available to trial the SERM in younger women, and we seek to extend our current SERM study into child bearing age women with schizophrenia.
From Brain Maps To Mechanisms: Modeling The Pathophysiology Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
My Fellowship will develop a framework that integrates brain imaging data with mathematical models of the brain to help understand the mechanisms responsible for schizophrenia. By linking functional Magnetic Resonance Imaging (fMRI) measurements to models of their underlying causes, the work may lead to new treatments that target the specific dysfunction in individuals with this debilitating brain disorder.
Rapidly giving intravenous fluid to prevent or treat shock (fluid resuscitation) is one of the commonest treatments given to critically ill patients. Current guidelines recommend crystalloid solutions but it is unknown whether any particular crystalloid is better than others. This trial will determine whether the use of one of two crystalloid fluids, saline or PlasmaLyte, reduces the risk of organ injuries, such as kidney failure, and improves patients chances of surviving critically illness.
Improving mental health nurses’ retention and quality of nursing practice. This project aims to improve mental health nurses’ resilience, retention and quality of practice through implementation of a resilience-building program. There is a critical national shortage of nurses in mental health, and attrition of the mental health nursing workforce is due in large part to workplace stressors. As a world-first in the field, the study will compare outcomes for mental health nurses who participate in ....Improving mental health nurses’ retention and quality of nursing practice. This project aims to improve mental health nurses’ resilience, retention and quality of practice through implementation of a resilience-building program. There is a critical national shortage of nurses in mental health, and attrition of the mental health nursing workforce is due in large part to workplace stressors. As a world-first in the field, the study will compare outcomes for mental health nurses who participate in the resilience program with a group of nurses who do not. Extending on a successful pilot, we expect the outcomes to be improved nurse resilience, turnover intention, and quality of nursing practice, and reduced negative psychological impacts of workplace stress. Read moreRead less
Special Research Initiatives - Grant ID: SR0354823
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
National network for the study of cognitive processes and treatment across the phases of schizophrenia. Schizophrenia is associated with great costs to the community and individual. Controlled studies have demonstrated Cognitive Behaviour Therapy (CBT) is efficacious in treating symptoms of schizophrenia. Studies of cognitive processes have also advanced understanding of psychotic phenomena. This initiative affords the opportunity to
1) Improve treatment efficacy by developing, testing and appl ....National network for the study of cognitive processes and treatment across the phases of schizophrenia. Schizophrenia is associated with great costs to the community and individual. Controlled studies have demonstrated Cognitive Behaviour Therapy (CBT) is efficacious in treating symptoms of schizophrenia. Studies of cognitive processes have also advanced understanding of psychotic phenomena. This initiative affords the opportunity to
1) Improve treatment efficacy by developing, testing and applying theoretically-driven models of psychotic symptoms.
2) Disseminate the findings of research on CBT for psychotic disorders in clinical settings by (a) training the work-force, and (b) facilitating CBT delivery in routine practice.
3) Apply CBT in various settings with a variety of psychotic populations to test its effectiveness in routine clinical settings.
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Prevention Of Complications In Type 2 Diabetes By Using ICT To Optimise Self-management
Funder
National Health and Medical Research Council
Funding Amount
$849,181.00
Summary
The impact of the diabetes epidemic on individuals and society is severe but can be reduced by improving diabetes self-management. Conducted in partnership with Diabetes Australia (Queensland, Victoria, WA) and Roche Diagnostics, this research will evaluate the 'real world' implementation of a telehealth program, already successfully trialled, which has the potential to provide a low cost and effective program to a large number of Australians with type 2 diabetes.
An exploratory cluster trial of a sustainable capacity building intervention to promote positive child mental health in Family Day Care. Rarely is solution-oriented intervention research built and conducted with rigorous research designs in communities of extreme disadvantage. This study builds on the enthusiasm of a leading child welfare organisation in its commitment to contribute to evidence for practice-oriented solutions. The research will serve as a model for the Family Day Care and childc ....An exploratory cluster trial of a sustainable capacity building intervention to promote positive child mental health in Family Day Care. Rarely is solution-oriented intervention research built and conducted with rigorous research designs in communities of extreme disadvantage. This study builds on the enthusiasm of a leading child welfare organisation in its commitment to contribute to evidence for practice-oriented solutions. The research will serve as a model for the Family Day Care and childcare sectors. The study is an essential step in the development of an intervention prior to a large-scale evaluation. With a strong evidence base, this program may be implemented widely within the sector nationally, thus addressing a key area of children's health inequalities - mental health.Read moreRead less
An Investigation of Intersubjectivity: Music Therapy and Hospitalised Infants. A contingent relationship is vital for normal infant development. The Neonatal Intensive Care Unit, which supplies life-saving modern medical technology to very sick infants, is also an environment where contingency is rarely available to the infant . In this environment, a Music Therapist ?improvising? with the infant, can re-introduce contingency to the infant, and encourage infant self-regulation. This project inv ....An Investigation of Intersubjectivity: Music Therapy and Hospitalised Infants. A contingent relationship is vital for normal infant development. The Neonatal Intensive Care Unit, which supplies life-saving modern medical technology to very sick infants, is also an environment where contingency is rarely available to the infant . In this environment, a Music Therapist ?improvising? with the infant, can re-introduce contingency to the infant, and encourage infant self-regulation. This project investigates the efficacy of a Music Therapy intervention in improving infant health, and micro-analyses the interaction between infant and therapist in order to further understand the nature of the Communicative Musicality of the interaction.Read moreRead less
Beyond Bullying in Primary Schools: Explicating Psychosocial Antecedents and Implementing an Effective Intervention to Enhance Pro-Social Behaviour, Well-Being and Academic Engagement. Early intervention to combat bullying in primary schools is vital given the pervasiveness and long-term consequences of bullying for academic failure, mental health costs, and anti-social behaviour. Consistent with National Research Priorities (promoting/maintaining good health & well-being), our research offers i ....Beyond Bullying in Primary Schools: Explicating Psychosocial Antecedents and Implementing an Effective Intervention to Enhance Pro-Social Behaviour, Well-Being and Academic Engagement. Early intervention to combat bullying in primary schools is vital given the pervasiveness and long-term consequences of bullying for academic failure, mental health costs, and anti-social behaviour. Consistent with National Research Priorities (promoting/maintaining good health & well-being), our research offers important educational and socio-economic benefits by enriching the psychosocial adjustment and life potential of young Australians. Effective intervention and explicating the determinants/consequences of primary school bullying enhances pro-social behaviours, self-concept, mental health, and school engagement of bullies and victims. This fosters safer schools that contribute to individual, local community, and national well-being.Read moreRead less
The Older Australian Twins Study (OATS) Of Healthy Brain Ageing And Age-related Neurocognitive Disorders
Funder
National Health and Medical Research Council
Funding Amount
$940,960.00
Summary
Ageing is associated with cognitive decline and dementia. It is still not completely understood what relative contributions genes and environment play in these. This project is an extension of the Older Australian Twins Study to examine genetic and environmental factors associated with late life brain changes and dementia, and will establish an internationally significant cohort for novel discovery.