The associative mechanisms underlying extinction and latent inhibition. Formal models that explain how animals learn associations between stimuli have enjoyed considerable success, and have even been identified with neurophysiological mechanisms. Theoretical analysis of the opposite, though equally important, form of learning - that two stimuli are not associated - lags far behind, due to fundamental methodological confounds that plague research on this topic. This project investigates two insta ....The associative mechanisms underlying extinction and latent inhibition. Formal models that explain how animals learn associations between stimuli have enjoyed considerable success, and have even been identified with neurophysiological mechanisms. Theoretical analysis of the opposite, though equally important, form of learning - that two stimuli are not associated - lags far behind, due to fundamental methodological confounds that plague research on this topic. This project investigates two instances of this learning: extinction and latent inhibition. Using a new procedure that avoids earlier confounds, we will describe and compare the processes underlying extinction and latent inhibition. This research will represent a major breakthrough in our understanding about fundamental processes in learning.Read moreRead less
Models of adolescent drug use and its consequences. Recent concerns surround the impact of drug abuse - particularly binge drinking, inhalant abuse and cannabis use - on the mental health of adolescents. Early drug use is associated with mental health problems although the mechanisms involved are not well characterised. The present proposal aims to use animal models to characterise substance abuse that occurs during the adolescent period and to investigate its effects on brain and behaviour. Inc ....Models of adolescent drug use and its consequences. Recent concerns surround the impact of drug abuse - particularly binge drinking, inhalant abuse and cannabis use - on the mental health of adolescents. Early drug use is associated with mental health problems although the mechanisms involved are not well characterised. The present proposal aims to use animal models to characterise substance abuse that occurs during the adolescent period and to investigate its effects on brain and behaviour. Increasing our knowledge of the causes and consequences of adolescent drug abuse will improve Australia's ability to confront this problem and to develop early interventions and treatments that minimise associated harms.Read moreRead less
Age-dependent effects of cannabinoids on emotion, cognition and vulnerablity to addiction. Cannabis is the most widely used illicit drug in Australia so understanding the effects of this drug is of great importance. There is little of no basic research on cannabis currently occurring in Australia. Yet such research is critical in resolving the ambiguities and difficulties inherent in our understanding of the drug. The importance of increasing our understanding of the long-term effects of the dr ....Age-dependent effects of cannabinoids on emotion, cognition and vulnerablity to addiction. Cannabis is the most widely used illicit drug in Australia so understanding the effects of this drug is of great importance. There is little of no basic research on cannabis currently occurring in Australia. Yet such research is critical in resolving the ambiguities and difficulties inherent in our understanding of the drug. The importance of increasing our understanding of the long-term effects of the drug on young developing brains is particularly evident. The information gained in the current project will serve to inform medical and scientific communities, government policy makers, as well as the broader Australian community. Read moreRead less
Australian Laureate Fellowships - Grant ID: FL0992409
Funder
Australian Research Council
Funding Amount
$2,996,243.00
Summary
The neural bases of decision-making. This research focuses on the neural bases of decision making, a general capacity affected by normal ageing, disorders associated with neurodegeneration including dementia, major psychiatric conditions and drug addiction. Changes in the neural systems that result in the cognitive and emotional dissociation reflected in these disorders constitute the highest health, economic and social capital attrition burden to Australia of any disease group, a burden that is ....The neural bases of decision-making. This research focuses on the neural bases of decision making, a general capacity affected by normal ageing, disorders associated with neurodegeneration including dementia, major psychiatric conditions and drug addiction. Changes in the neural systems that result in the cognitive and emotional dissociation reflected in these disorders constitute the highest health, economic and social capital attrition burden to Australia of any disease group, a burden that is only predicted to increase as the population ages. Understanding these changes in neural systems and their specific behavioural effects is, therefore, of critical importance and will ultimately provide new targets for treatment and rehabilitation.Read moreRead less
Fear, sadness and alcohol in adolescence: A test of innovative curriculum models to prevent adverse outcomes. Lack of mastery over fear, sadness and alcohol use are risk factors for the common forms of mental ill health. When fully developed, anxiety, depressive and substance use disorders account for three quarters of the disability attributed to mental disorders. While prevention strategies exist, none are universally feasible. Climate schools represents a utility that is acceptable, fits with ....Fear, sadness and alcohol in adolescence: A test of innovative curriculum models to prevent adverse outcomes. Lack of mastery over fear, sadness and alcohol use are risk factors for the common forms of mental ill health. When fully developed, anxiety, depressive and substance use disorders account for three quarters of the disability attributed to mental disorders. While prevention strategies exist, none are universally feasible. Climate schools represents a utility that is acceptable, fits within the school syllabus, is effective, and is scaleable to meet the needs of all schools in Australia. If it reduces the target risk factors by 10-20%, a minimal estimate based on the pilot work, then it will be a most cost effective contribution to promoting and maintaining the good health of the community.
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Youth off the streets (YOTS): Rehabilitating at-risk youth and young offenders through responsive service learning programs. Young people involved in substance abuse and delinquency are a major economic and social cost to Australia. Although numerous crime prevention strategies have been developed for working with at-risk, homeless, substance abusing and delinquent young people, few have been adequately evaluated and outcomes are poor. Almost none reflect contemporary knowledge in theories of a ....Youth off the streets (YOTS): Rehabilitating at-risk youth and young offenders through responsive service learning programs. Young people involved in substance abuse and delinquency are a major economic and social cost to Australia. Although numerous crime prevention strategies have been developed for working with at-risk, homeless, substance abusing and delinquent young people, few have been adequately evaluated and outcomes are poor. Almost none reflect contemporary knowledge in theories of adolescent development. This research will develop an innovative intervention based on Service Learning relevant to other diversion programs within Juvenile Justice and an industry model for long-term sustainable program evaluation. We will also develop an intervention model relevant to other organisations with similar aims and budgetary constraints.Read moreRead less