When is extinction not extinction? Disorders of fear and anxiety are widespread and impose significant burdens on individual sufferers and their families. This projects studies new ways of augmenting loss of fear and will identify the important behavioural mechanisms as well as critical brain pathways for this fear loss.
Uncertainty and response control in the prefrontal cortex. This project will identify how complex behaviours come to be performed habitually. It is proposed that statistical certainty in the learning environment is a key determinant of automatic behaviour, that detection of uncertainty can restore voluntary control of behaviour and that this is an important function of the prefrontal cortex of the brain.
Into the thirties: Persistence and social consequences of risky drinking. The aim of this project is to investigate the social contexts, roles and consequences of problematic alcohol use in adults aged 30, using long term longitudinal resources able to observe the development and corollary of alcohol use over time. It is posited that such drinkers entering their third decade of life persist in levels of problematic alcohol use typically associated with younger ages and that this leads to social ....Into the thirties: Persistence and social consequences of risky drinking. The aim of this project is to investigate the social contexts, roles and consequences of problematic alcohol use in adults aged 30, using long term longitudinal resources able to observe the development and corollary of alcohol use over time. It is posited that such drinkers entering their third decade of life persist in levels of problematic alcohol use typically associated with younger ages and that this leads to social consequences, such as gender specific risks, relationship conflicts and more severe long term effects. Outcomes from this project are expected to inform the generation of relevant prevention and intervention strategies aimed to address problem drinking in adult Australians.Read moreRead less
Stopping the run-around: comorbidity action in the north (CAN). The purpose of the project is to identify the barriers and facilitators to effective use of mental health and drug and alcohol services in a metropolitan region of South Australia. The evidence base will then drive the development and implementation of effective change to service delivery to improve outcomes for people with comorbidity.
Discovery Early Career Researcher Award - Grant ID: DE170100509
Funder
Australian Research Council
Funding Amount
$388,000.00
Summary
Molecular mechanisms causing relapse. This project aims to identify the neural connectivity and molecular profile of ventral pallidal neurons in the brain that control drug and alcohol addiction, relapsing disorders where users lose the ability to inhibit drug seeking behaviour. This project integrates neurobiological and psychological attributes of relapse. The anticipated outcomes provide insights about molecular mechanisms causing relapse, and expand knowledge of brain mechanisms that contrib ....Molecular mechanisms causing relapse. This project aims to identify the neural connectivity and molecular profile of ventral pallidal neurons in the brain that control drug and alcohol addiction, relapsing disorders where users lose the ability to inhibit drug seeking behaviour. This project integrates neurobiological and psychological attributes of relapse. The anticipated outcomes provide insights about molecular mechanisms causing relapse, and expand knowledge of brain mechanisms that contribute to relapsing disorders such as drug addiction and obesity. The findings from this project could be used to reduce relapse, and hence reduce the burden of alcohol related problems on health, the community and the Australian economy.Read moreRead less
Action-related learning and plasticity in the cortico-striatal network. This project focuses on the neural bases of adaptive behaviour, specifically on the neural processes through which new actions are acquired. This project aims to establish the neural networks involved as well as the locus of the critical cellular plasticity mediating this learning process in the brain.
Bioactive Peptides as Pharmacological Tools and Novel Drug Leads. Bioactive peptides are produced by all organisms and play numerous critical physiological roles, including in cellular communication, host defence and capture of prey. Peptides have huge potential as tools for studying roles of signalling pathways and as novel drugs due to their high affinity and selectivity for various therapeutically relevant targets. However their use has been limited by poor in vivo stability. This project is ....Bioactive Peptides as Pharmacological Tools and Novel Drug Leads. Bioactive peptides are produced by all organisms and play numerous critical physiological roles, including in cellular communication, host defence and capture of prey. Peptides have huge potential as tools for studying roles of signalling pathways and as novel drugs due to their high affinity and selectivity for various therapeutically relevant targets. However their use has been limited by poor in vivo stability. This project is focused on studying structural features of a range of peptides and their contributions to both activity and to resistance against degradation, with the aim to develop stabilised bioactive peptide sequences for in vivo applications, allowing the full potential of peptides as drugs to be realised.Read moreRead less
Cannabis and the brain: the good, the bad and the unknown. Cannabis is the most widely used illicit drug but much remains unknown about how it affects the brain. This research will examine effects on brain cells through to whole brain function in humans to determine how cannabis use may lead to impaired thinking or psychological symptoms and why cannabis might affect individuals in different ways.
Estimating the population effect of maternal alcohol-use disorders on the educational achievement of children. It is unclear to what extent maternal alcohol-related problems contribute to the increased risk of poor health, academic failure, and times suspended from school in Australian children. This study aims to examine the effect of maternal alcohol-use disorder on infant and child health, development, and educational achievement using education and health data from the Western Australian dat ....Estimating the population effect of maternal alcohol-use disorders on the educational achievement of children. It is unclear to what extent maternal alcohol-related problems contribute to the increased risk of poor health, academic failure, and times suspended from school in Australian children. This study aims to examine the effect of maternal alcohol-use disorder on infant and child health, development, and educational achievement using education and health data from the Western Australian data linkage system. The results will provide new information on the impact of maternal alcohol-related problems on child health and educational achievement and have the potential to inform health and education policies and early identification and targeted intervention strategies. Read moreRead less