Progesterone Receptor-mediated Coordination Of Oocyte-oviduct Communication During Ovulation
Funder
National Health and Medical Research Council
Funding Amount
$86,128.00
Summary
Infertility affects 1 in 6 couples, often due to failed release of an egg from the ovary. The hormone progesterone is essential for this process. Our goal is to determine how progesterone signals the egg to ensure its correct release into the oviduct where fertilization may occur. To identify these signals, experiments will analyse ovary cells and eggs of mice, including mice that do not respond to progesterone. The results will provide much needed information about female reproductive health.
Personalised Medicine Markers Of Anti-EGFR Antibody Therapy In Metastatic Colorectal Cancer: Accelerating Clinical Translation With Collaborative Meta-analyses Based On Individual-participant Data
Funder
National Health and Medical Research Council
Funding Amount
$300,953.00
Summary
When selecting cancer therapy we take into account ‘biomarkers’, biological cancer characteristics that predict treatment success. We will work with an international group, the Advanced Colorectal Cancer Database, to analyse individual patient clinical trial data. We intend to validate biomarkers used to select treatment with cetuximab or panitumumab. Cancer genes called KRAS, NRAS, PTEN, PIK3CA, EREG and BRAF will be examined. Our study will provide best evidence for personalised treatment.
Targeting Sphingosine Kinase 1 To Sensitise Acute Myeloid Leukaemia To BH3 Mimetic Therapy
Funder
National Health and Medical Research Council
Funding Amount
$670,005.00
Summary
Acute Myeloid Leukaemia (AML) patients are currently treated with chemotherapeutics and despite their success at achieving disease remission these responses are often short lived, resulting in relapse and death. We have identified sphingosine kinase 1 as a new drug target in AML. This proposal aims to examine the role of targeting sphingosine kinase 1 in combination with new targeted therapies in patient samples and preclinical mouse models of AML.
Discovery Early Career Researcher Award - Grant ID: DE230100249
Funder
Australian Research Council
Funding Amount
$464,162.00
Summary
Enhancing belonging for African diaspora youth in Australian schools . Schools are key sites to counter marginalisation and enable belonging. This study will investigate how Black African diaspora youth experience belonging in Australian schools and ways that schools can change practices to enhance belonging. The project will generate new knowledge of belonging and its importance for schooling using innovatory Participatory Action Research with African youth and teachers. Expected outcomes are d ....Enhancing belonging for African diaspora youth in Australian schools . Schools are key sites to counter marginalisation and enable belonging. This study will investigate how Black African diaspora youth experience belonging in Australian schools and ways that schools can change practices to enhance belonging. The project will generate new knowledge of belonging and its importance for schooling using innovatory Participatory Action Research with African youth and teachers. Expected outcomes are directions for education policy and practices, development of professional resources for working with diasporic students and capacitating young African people as researchers. Anticipated benefits are improved school engagement, retention and outcomes for African diaspora youth and insights for other marginalised youth.Read moreRead less