Flipping the mattress: infinite polyurethane recycling by synthetic biology. Australia is covered in billions of tonnes of plastic and yet <10% is recycled today. Polyurethane (PU) is ubiquitous in our everyday lives, from lacquer coatings to elastane clothing to durable foam padding in car seats, cushions and mattresses. Currently, there are few avenues for PU recycling and much ends up in landfill e.g., a single mattress produces 15-20kg of PU foam waste. Luckily, biodegradation of PU can occu ....Flipping the mattress: infinite polyurethane recycling by synthetic biology. Australia is covered in billions of tonnes of plastic and yet <10% is recycled today. Polyurethane (PU) is ubiquitous in our everyday lives, from lacquer coatings to elastane clothing to durable foam padding in car seats, cushions and mattresses. Currently, there are few avenues for PU recycling and much ends up in landfill e.g., a single mattress produces 15-20kg of PU foam waste. Luckily, biodegradation of PU can occur naturally via various microbial means and from insects, like Galleria mellonella larvae. The overall aim of this research project is to understand plastic biodegradation and translate nature’s solutions into flexible and efficient synthetic enzyme technologies that can sustainably recycle commonly used PU foams. Read moreRead less
Novel biological and genetic disease control tools for the barley industry. This project places Australian barley breeders at the forefront of disease resistance by providing them with novel tools to develop varieties with enhanced protection against fungal diseases. The aims are to produce fungal strains with multiple virulence genes for fast and cost-effective testing of barley lines, untangle the fungal/host gene interaction for resistance breeding and identify new sources of resistance. The ....Novel biological and genetic disease control tools for the barley industry. This project places Australian barley breeders at the forefront of disease resistance by providing them with novel tools to develop varieties with enhanced protection against fungal diseases. The aims are to produce fungal strains with multiple virulence genes for fast and cost-effective testing of barley lines, untangle the fungal/host gene interaction for resistance breeding and identify new sources of resistance. The outcomes will lead to the commercialisation by Australian breeding companies of barley varieties with durable fungal resistance. This will benefit the Australian economy by providing sustainability and protection for barley breeding thereby significantly reducing crop losses for this important global agricultural commodity.Read moreRead less
The infectome of NSW dairy calves, a genomic microbial surveillance . Infectious diseases are the main cause of disease and mortality in calves. The knowledge of the diversity of infectious disease-causing agents in NSW dairy cattle is not comprehensive. Thus, the immediate goal of this proposal is to redress this knowledge gap using untargeted microbial genomic sequencing to characterise and identify known and emerging enteric and respiratory pathogens in dairy calves. We will determine the occ ....The infectome of NSW dairy calves, a genomic microbial surveillance . Infectious diseases are the main cause of disease and mortality in calves. The knowledge of the diversity of infectious disease-causing agents in NSW dairy cattle is not comprehensive. Thus, the immediate goal of this proposal is to redress this knowledge gap using untargeted microbial genomic sequencing to characterise and identify known and emerging enteric and respiratory pathogens in dairy calves. We will determine the occurrence and distribution of their microbial species across all NSW dairy regions. This will enable the Australian dairy industry to improve animal health and productivity, and diagnostic capacity, which will allow farmers to make informed management decisions about disease control strategies. Read moreRead less
Biogeochemical remediation approaches for PFAS contaminated environments. This project aims to identify and harvest microorganisms capable of directly or indirectly affecting PFOS or PFOA degradation in the environment. Fluorinated compounds such as PFOS and PFOA in firefighting foams are contaminants of concern now routinely detected in contaminated groundwater and soil globally. Understanding the role of microorganisms, and the biogeochemical processes they perform in relation to fluorinated c ....Biogeochemical remediation approaches for PFAS contaminated environments. This project aims to identify and harvest microorganisms capable of directly or indirectly affecting PFOS or PFOA degradation in the environment. Fluorinated compounds such as PFOS and PFOA in firefighting foams are contaminants of concern now routinely detected in contaminated groundwater and soil globally. Understanding the role of microorganisms, and the biogeochemical processes they perform in relation to fluorinated compounds, will inform handling of contaminated sites and lead to development of cost effective and sustainable remediation technologies. Read moreRead less
Resolving the Genetics of Grain Pigmentation Traits in Rice . New critical knowledge will enable future breeding of quality black rice cultivars that can exploit the high UV Australian growing environment to enable domestic production of high-value, healthy black rice. The demand for functional foods with health benefits, including black rice, is increasing both domestically and internationally. The concentration of key functional compounds in black rice may be increased by growing optimised cul ....Resolving the Genetics of Grain Pigmentation Traits in Rice . New critical knowledge will enable future breeding of quality black rice cultivars that can exploit the high UV Australian growing environment to enable domestic production of high-value, healthy black rice. The demand for functional foods with health benefits, including black rice, is increasing both domestically and internationally. The concentration of key functional compounds in black rice may be increased by growing optimised cultivars under high-UV radiation, making Australia well placed to produce the highest quality black rice. Utilising a unique genetic resource this project will resolve how the interaction between crop genetics and the growing environment drives the concentration of functional compounds in black rice. Read moreRead less
Breaking critical barriers in soil formation of bauxite residues . Conventional methods of bauxite residue rehabilitation require expensive and unsustainable covering topsoil. Building on recent breakthroughs in eco-engineering tailings into soil, the project aims to develop a field-based technology using marine microbes and halophytic plants to accelerate in-situ soil formation from bauxite residues (incl seawater neutralised bauxite residues) under field conditions. The technology will be unde ....Breaking critical barriers in soil formation of bauxite residues . Conventional methods of bauxite residue rehabilitation require expensive and unsustainable covering topsoil. Building on recent breakthroughs in eco-engineering tailings into soil, the project aims to develop a field-based technology using marine microbes and halophytic plants to accelerate in-situ soil formation from bauxite residues (incl seawater neutralised bauxite residues) under field conditions. The technology will be underpinned by understanding the roles of marine microbe consortia and eco-engineering inputs in accelerating key mineralogical, geochemical, physical and biological changes in bauxite residues. This technology is expected to be transferable and adaptable across other alumina refineries in Australia.Read moreRead less
FastStack - evolutionary computing to stack desirable alleles in wheat. This project aims to investigate rapid development of new, high-yielding wheat varieties with appropriate disease resistance. An emerging challenge in wheat breeding is how to stack desirable alleles for disease resistance, drought, and end-use quality into new varieties with high yielding backgrounds in the shortest time. As the number of known desirable alleles for these traits increases, the number of possible crossing c ....FastStack - evolutionary computing to stack desirable alleles in wheat. This project aims to investigate rapid development of new, high-yielding wheat varieties with appropriate disease resistance. An emerging challenge in wheat breeding is how to stack desirable alleles for disease resistance, drought, and end-use quality into new varieties with high yielding backgrounds in the shortest time. As the number of known desirable alleles for these traits increases, the number of possible crossing combinations that need to be considered increases. This project aims to use evolutionary computing with speed breeding and genomic selection, in the partners breeding program, to address this challenge. Potential outcomes will lead to more profitable wheat varieties for Australian growers, and expanded exports to high value markets that require quality grain.Read moreRead less
Will genetic rescue save the Tasmanian devil? This project aims to measure the long-term genetic impacts of the Save the Tasmanian Devil Program’s ‘Wild Devil Recovery’ initiative. The project will determine whether supplementing small populations with individuals that are genetically diverse reduces inbreeding depression. The project will also monitor the impact of supplementation on the evolutionary trajectory of Devil Facial Tumour Disease. The project will train a cohort of conservation scie ....Will genetic rescue save the Tasmanian devil? This project aims to measure the long-term genetic impacts of the Save the Tasmanian Devil Program’s ‘Wild Devil Recovery’ initiative. The project will determine whether supplementing small populations with individuals that are genetically diverse reduces inbreeding depression. The project will also monitor the impact of supplementation on the evolutionary trajectory of Devil Facial Tumour Disease. The project will train a cohort of conservation scientists to translate genetic data into management actions. The outputs will directly inform the management actions of the Tasmanian Department of Primary Industries Parks, Water and the Environment and will help shape other species recovery programs.Read moreRead less
Unlocking the genetic and biochemical potential of kangaroo paws. Using cutting-edge gene technology and an interdisciplinary approach, this project aims to uncover the genes responsible for flower colour in the iconic kangaroo paws of Western Australia, and identify the compounds that produce the colours. The project expects to produce the first entire kangaroo paw genome and identify unique genetic variants and biochemicals underlying colour differences. This new knowledge should help horticul ....Unlocking the genetic and biochemical potential of kangaroo paws. Using cutting-edge gene technology and an interdisciplinary approach, this project aims to uncover the genes responsible for flower colour in the iconic kangaroo paws of Western Australia, and identify the compounds that produce the colours. The project expects to produce the first entire kangaroo paw genome and identify unique genetic variants and biochemicals underlying colour differences. This new knowledge should help horticultural programs to more easily breed varieties with desirable and highly marketable new colours, and could assist in conserving these amazing Australian plants.Read moreRead less
Enhancing Genomic Prediction for Changing Environments in Wheat. Adverse weather is the primary risk faced by the Australian agriculture industry. This Project aims to develop the next generation of agriculture tools to unlock natural potential in wheat and improve yield stability across seasons and regions. Drawing on crop physiology, genetics and integrated modelling, this Project expects to generate new knowledge and technologies to untangle genetic and environmental interactions that affect ....Enhancing Genomic Prediction for Changing Environments in Wheat. Adverse weather is the primary risk faced by the Australian agriculture industry. This Project aims to develop the next generation of agriculture tools to unlock natural potential in wheat and improve yield stability across seasons and regions. Drawing on crop physiology, genetics and integrated modelling, this Project expects to generate new knowledge and technologies to untangle genetic and environmental interactions that affect productivity, enhance predictive capability, and initiate advanced breeding strategies to develop new crop varieties with superior resilience against changing climates. This should provide significant benefits, such as profit stability for wheat growers, elevated global market position and improved food security.Read moreRead less