Detection and viability of waterborne pathogens using a gut-on-chip. This project aims to resolve a significant problem for water utilities. Microbial pathogens Cryptosporidium, norovirus and adenovirus are the main public health concern for drinking water in developed nations. Water monitoring is limited by the lack of fast, reliable detection methods and viability assays for these pathogens. This project will use a novel gut-on-a-chip to develop for the first time rapid infectivity assays for ....Detection and viability of waterborne pathogens using a gut-on-chip. This project aims to resolve a significant problem for water utilities. Microbial pathogens Cryptosporidium, norovirus and adenovirus are the main public health concern for drinking water in developed nations. Water monitoring is limited by the lack of fast, reliable detection methods and viability assays for these pathogens. This project will use a novel gut-on-a-chip to develop for the first time rapid infectivity assays for Cryptosporidium, norovirus and adenovirus. Significant benefits include improved diagnostics and water disinfection assays, improved water treatment and reduced costs with global impact.Read moreRead less
The adaptive evolution of key methane-utilising microorganisms. This project aims to characterise the evolutionary adaptations of a group of microorganisms with a key role in mitigating the release of methane into the atmosphere. Innovative molecular and visualisation-based approaches will be applied to uncover their metabolic diversity and evolutionary history. An important outcome of this study will be the comprehensive understanding of the contribution and impact these microorganisms have on ....The adaptive evolution of key methane-utilising microorganisms. This project aims to characterise the evolutionary adaptations of a group of microorganisms with a key role in mitigating the release of methane into the atmosphere. Innovative molecular and visualisation-based approaches will be applied to uncover their metabolic diversity and evolutionary history. An important outcome of this study will be the comprehensive understanding of the contribution and impact these microorganisms have on the global carbon cycle, which will importantly inform accurate climate change models. This has clear benefits for society, given the precision of such models is essential in our ability to minimise the impact and associated cost of global warming.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100388
Funder
Australian Research Council
Funding Amount
$437,977.00
Summary
Ecological and phylogenomic insights into infectious diseases in animals. This project aims to address major knowledge gaps in our understanding of Clostridium difficile, a leading cause of severe gastrointestinal disease in animals. The project is expected to define the epidemiology of C. difficile infection in Australian horses, characterise the genetic and phenotypic traits of C. difficile strains causing equine disease and develop a new tool for enhanced genomic tracking of C. difficile in a ....Ecological and phylogenomic insights into infectious diseases in animals. This project aims to address major knowledge gaps in our understanding of Clostridium difficile, a leading cause of severe gastrointestinal disease in animals. The project is expected to define the epidemiology of C. difficile infection in Australian horses, characterise the genetic and phenotypic traits of C. difficile strains causing equine disease and develop a new tool for enhanced genomic tracking of C. difficile in animals. These outcomes will support strategies by the veterinary sector to improve the detection, prevention and control of C. difficile infections in animals, providing long-term socio-economic benefits arising from reduced incidence and mortality associated with C. difficile infections in Australian horses and livestock.Read moreRead less
Harnessing horizontal gene transfer for sustainable nitrogen fixation. This project aims to investigate natural deoxyribonucleic acid (DNA) transfer from nitrogen-fixing bacteria to indigenous bacteria in Australian soils. This project expects to significantly expand our understanding of the molecular and genetic factors contributing to the evolution of ineffective symbiotic bacteria in these soils. An expected outcome of this project is support development of genetically stable bacterial inocul ....Harnessing horizontal gene transfer for sustainable nitrogen fixation. This project aims to investigate natural deoxyribonucleic acid (DNA) transfer from nitrogen-fixing bacteria to indigenous bacteria in Australian soils. This project expects to significantly expand our understanding of the molecular and genetic factors contributing to the evolution of ineffective symbiotic bacteria in these soils. An expected outcome of this project is support development of genetically stable bacterial inoculants for use in agriculture. Inoculation of legumes with nitrogen-fixing symbiotic bacteria is a cheap and environmentally-friendly alternative to chemical fertilisers and contributes $3-4 billion per annum to Australian economy.Read moreRead less
Mid-Career Industry Fellowships - Grant ID: IM230100154
Funder
Australian Research Council
Funding Amount
$1,049,904.00
Summary
Fungi Power: Designer Fungal Cell Factories for Advanced Biomanufacturing. This project aims to build an advanced biomanufacturing platform based on filamentous fungi in collaboration with industry. Using synthetic biology, the project expects to engineer superior fungal host strains customisable to the needs of the industry and to address their technological gaps. The expected outcomes include the development of cost-efficient and sustainable fungal-based bioprocesses for the companies to produ ....Fungi Power: Designer Fungal Cell Factories for Advanced Biomanufacturing. This project aims to build an advanced biomanufacturing platform based on filamentous fungi in collaboration with industry. Using synthetic biology, the project expects to engineer superior fungal host strains customisable to the needs of the industry and to address their technological gaps. The expected outcomes include the development of cost-efficient and sustainable fungal-based bioprocesses for the companies to produce products, such as fine chemicals, pharmaceutical actives and food ingredients. The project would provide significant benefits by enabling existing and emerging companies' commercial successes and competitiveness in global markets, creating new jobs and resulting in the growth of the bio-economy in Australia.Read moreRead less
Dual-membrane upgrading towards sustainable wastewater management. Water utilities in Australia have set aspirational targets for energy- and carbon-neutral wastewater services by as early as 2030. However, these two aims are often incompatible because of excessive aeration energy consumption and substantial greenhouse gas emissions in wastewater treatment plants. This project aims to develop a novel biotechnology that enables simultaneous bioenergy recovery, cost-efficient nitrogen removal and ....Dual-membrane upgrading towards sustainable wastewater management. Water utilities in Australia have set aspirational targets for energy- and carbon-neutral wastewater services by as early as 2030. However, these two aims are often incompatible because of excessive aeration energy consumption and substantial greenhouse gas emissions in wastewater treatment plants. This project aims to develop a novel biotechnology that enables simultaneous bioenergy recovery, cost-efficient nitrogen removal and mitigation of greenhouse gas emissions, thus bringing multifaceted benefits to wastewater management. The project will provide strong support to the Australian water industry in their endeavour to achieve economically and environmentally sustainable wastewater services.Read moreRead less
Multifunctional and environmentally friendly corrosion inhibitor systems. This project aims to design new, environmentally friendly coating systems for steel in marine environments by incorporating novel, non-toxic pigments that can be combined to protect against both corrosion and microbial attack. Structural requirements for these compounds will be determined through the use of advanced characterisation techniques to identify the largely unknown mechanisms of attachment and protection on steel ....Multifunctional and environmentally friendly corrosion inhibitor systems. This project aims to design new, environmentally friendly coating systems for steel in marine environments by incorporating novel, non-toxic pigments that can be combined to protect against both corrosion and microbial attack. Structural requirements for these compounds will be determined through the use of advanced characterisation techniques to identify the largely unknown mechanisms of attachment and protection on steel surfaces. The components may themselves be dual active, or be combined to capitalise on individual protection mechanisms that provide a synergy whereby the combination leads to better protection outcomes. Such coatings have the potential to significantly improve the lifetime of marine infrastructure.Read moreRead less
Unleashing the Hidden Chemical Diversity in Australian Fungi. This project aims to exploit an exclusive genomic resource consisting of >150 unique Australian filamentous fungi that has been built in a university-industry collaboration for genomic-guided biodiscovery. The genome sequence of these fungi revealed extensive hidden genetic instructions for production of novel biologically active molecules. The project will apply cutting-edge synthetic biology and chemical tools to tap into the hidden ....Unleashing the Hidden Chemical Diversity in Australian Fungi. This project aims to exploit an exclusive genomic resource consisting of >150 unique Australian filamentous fungi that has been built in a university-industry collaboration for genomic-guided biodiscovery. The genome sequence of these fungi revealed extensive hidden genetic instructions for production of novel biologically active molecules. The project will apply cutting-edge synthetic biology and chemical tools to tap into the hidden genomic potential of these Australian fungi. Expected outcomes of this project include new fine chemicals and lead molecules with desirable bioactivies. This will provide significant benefits to Australia's economy through the discovery of new pharmaceuticals, veterinary products and agrichemicals.Read moreRead less
Investigations into the antibacterial mechanism of action of cannabidiol. This project aims to understand how the compound cannabidiol is able to kill bacteria by examining its interactions with bacteria from a genetic and molecular level. This research is critical, because future development of cannabidiol and design of improved analogs is predicated on knowing how it works. Expected outcomes include the first detailed understanding of how cannabidiol interacts with bacteria. This should lead ....Investigations into the antibacterial mechanism of action of cannabidiol. This project aims to understand how the compound cannabidiol is able to kill bacteria by examining its interactions with bacteria from a genetic and molecular level. This research is critical, because future development of cannabidiol and design of improved analogs is predicated on knowing how it works. Expected outcomes include the first detailed understanding of how cannabidiol interacts with bacteria. This should lead to significant benefits, including high impact publications, additional collaborations with industrial partner Botanix, and a new class of antibiotics to overcome antibiotic resistance.Read moreRead less