Investigating the molecular mechanisms underlying non-visual photoreception and their implications in the treatment of human neurological disease. The ability of organisms to detect light is fundamental for survival and has been a major driver in evolution. The project will investigate the genetic origins of the various visual and non-visual systems and will explore its implications for the bioengineering of therapeutics for the treatment of neurological disease in humans.
Trapped Ion Imaging for Biomolecular Dynamics. The functionality of large biological molecules is driven by their chemical composition and the folded shape of their active form. The higher-order structure and dynamics of nucleic acids, proteins, carbohydrates, and lipids drives the chemistry of life. Combining single molecule microscopy and trapped ion mass spectroscopy will develop a new tool for precision measurements of higher-order folding dynamics in large biomolecules. Optical techniques i ....Trapped Ion Imaging for Biomolecular Dynamics. The functionality of large biological molecules is driven by their chemical composition and the folded shape of their active form. The higher-order structure and dynamics of nucleic acids, proteins, carbohydrates, and lipids drives the chemistry of life. Combining single molecule microscopy and trapped ion mass spectroscopy will develop a new tool for precision measurements of higher-order folding dynamics in large biomolecules. Optical techniques including Förster resonance energy transfer and super-resolution imaging can register changes in shape down to the nanometer scale. The uniquely adaptable ion trap environment enables manipulation of the surrounding solvent cage, temperature, and net charge down to the single quantum level. Read moreRead less
Why certain viruses don't get along in mosquitoes. The molecular mechanism. The overall goal of this project is to obtain an understanding of how certain insect-only viruses make mosquitoes incapable of transmitting diseases. These viruses, called insect-specific flaviviruses, can be employed as biocontrol agents for mosquito-borne human and veterinary diseases. However as it is currently unknown how exactly they affect mosquitoes, the safety and efficacy of their use can't be predicted. The pro ....Why certain viruses don't get along in mosquitoes. The molecular mechanism. The overall goal of this project is to obtain an understanding of how certain insect-only viruses make mosquitoes incapable of transmitting diseases. These viruses, called insect-specific flaviviruses, can be employed as biocontrol agents for mosquito-borne human and veterinary diseases. However as it is currently unknown how exactly they affect mosquitoes, the safety and efficacy of their use can't be predicted. The proposed project will dissect the very intricate mechanisms of interactions between insect-specific flaviviruses and mosquitoes and explain how exactly they prevent disease transmission. It should generate novel fundamental knowledge, implement innovative methodologies and provide training for students and junior scientist. Read moreRead less
Quantum-Assisted Sensing. Modern physics has been very successful at developing incredibly precise theoretical descriptions of nature. Can exquisitely accurate models of the interaction between light and matter, to push sensing and measurement far beyond the current state-of-the art, be exploited? This project aims to address this question, focussing on three domains of measurement: temperature, time and power. Improving sensors and measurement has been the cornerstone of new physical discoverie ....Quantum-Assisted Sensing. Modern physics has been very successful at developing incredibly precise theoretical descriptions of nature. Can exquisitely accurate models of the interaction between light and matter, to push sensing and measurement far beyond the current state-of-the art, be exploited? This project aims to address this question, focussing on three domains of measurement: temperature, time and power. Improving sensors and measurement has been the cornerstone of new physical discoveries, with applications from radio-astronomy to quantum information and navigation. This project aims to build the theoretical foundations for world-beating thermometers, clocks, and photon counters, and to guide experiments in Australia and abroad to bring them into reality.Read moreRead less
Spin-orbit-coupled Bose-Einstein Condensates. This project will explore fundamentally new quantum states, the spin-orbit Bose-Einstein condensates, predicted theoretically by Galitski et al. and subsequently observed experimentally. These states host a variety of fascinating novel phenomena, which can be exploited for ultra-sensitive interferometry and topological quantum computing. The project will develop a complete description of these phases and design new quantum devices that utilise their ....Spin-orbit-coupled Bose-Einstein Condensates. This project will explore fundamentally new quantum states, the spin-orbit Bose-Einstein condensates, predicted theoretically by Galitski et al. and subsequently observed experimentally. These states host a variety of fascinating novel phenomena, which can be exploited for ultra-sensitive interferometry and topological quantum computing. The project will develop a complete description of these phases and design new quantum devices that utilise their properties. The fundamental significance of the project is in bringing together ideas from the diverse fields of atomic and molecular physics, condensed matter, quantum information, and topology and its direct relevance to the development of a new generation of quantum devices.Read moreRead less
Collision physics in lighting, fusion and astrophysical plasmas. The project will apply advanced fundamental science techniques to applications that have a high impact on the environment. These include improving energy efficiency of fluorescent lamps and development of new mercury-free designs and research in support of the international multi-billion dollar fusion energy program.
Factors causing wheat stripe rust epidemics. This project aims to tackle wheat stripe rust, one of the most important fungal diseases of wheat in Australia, causing losses of up to $125 million a year. This project expects to gain insights into the fungal evolution and the molecular mechanism that causes hyper-virulent pathogen isolates. The expected outcome is to identify and characterise multiple genetic factors in the pathogen that contribute to wheat stripe rust epidemics in Australia. This ....Factors causing wheat stripe rust epidemics. This project aims to tackle wheat stripe rust, one of the most important fungal diseases of wheat in Australia, causing losses of up to $125 million a year. This project expects to gain insights into the fungal evolution and the molecular mechanism that causes hyper-virulent pathogen isolates. The expected outcome is to identify and characterise multiple genetic factors in the pathogen that contribute to wheat stripe rust epidemics in Australia. This project will contribute to improved disease management strategies to contain wheat stripe rust, resulting in higher wheat yields, reduced application of fungicides and increased revenue for Australian wheat farmers.Read moreRead less
Understanding somatic mutation in plants: new methods, new software, new data. Somatic mutations accumulate as plants grow, affecting everything from short-term ecological interactions to long-term evolutionary dynamics. These mutations have important consequences for plant industry and conservation, but because they are so hard to measure almost nothing is known about them. This project aims to develop new methods and software to detect, analyse, and compare the genome-wide history of somatic m ....Understanding somatic mutation in plants: new methods, new software, new data. Somatic mutations accumulate as plants grow, affecting everything from short-term ecological interactions to long-term evolutionary dynamics. These mutations have important consequences for plant industry and conservation, but because they are so hard to measure almost nothing is known about them. This project aims to develop new methods and software to detect, analyse, and compare the genome-wide history of somatic mutation in individual plants, providing an unprecedented level of detail into an important but understudied source of biological variation. By applying these methods to an iconic experimental population, This project aims to provide the first insights into the genome-wide causes and consequences of somatic mutation in plants.Read moreRead less
Numerical modelling of the solar atmosphere. This project will develop a complete and realistic model of the magnetic solar activity using computer simulations of the interconnected solar interior and atmosphere. The results of this project will provide a deeper insight into the physical processes behind solar activity phenomena and will help in the development of methods of solar activity prediction.
Tools for manipulating neuronal activity for behavioural studies. This project aims to develop optogenetic tools neuroscientists can use to better understand brain circuitry and the functional effects of specific neurons on behaviour. Linking the activity of individual neurons in the brain to specific behaviours is a major challenge in neuroscience. Optogenetics achieve this by using light to control the activity of neurons. This has advanced understanding of behaviour and neurocircuitry. This p ....Tools for manipulating neuronal activity for behavioural studies. This project aims to develop optogenetic tools neuroscientists can use to better understand brain circuitry and the functional effects of specific neurons on behaviour. Linking the activity of individual neurons in the brain to specific behaviours is a major challenge in neuroscience. Optogenetics achieve this by using light to control the activity of neurons. This has advanced understanding of behaviour and neurocircuitry. This project is expected to increase understanding of brain function at the cellular and system levels, and advance Australia’s multidisciplinary research capacity in neuroscience, cognitive sciences and nanobiotechnology to ultimately treat neurological disorders.Read moreRead less