Discovery Early Career Researcher Award - Grant ID: DE160101570
Funder
Australian Research Council
Funding Amount
$352,000.00
Summary
Inducible hyper-expression as a tool for metabolic engineering. This project aims to develop methods to improve plant natural products yields and diversify the products manufactured from a wide array of plant species. Valuable plant metabolites, including chemotherapeutics and opiates, are usually synthesised in minute amounts and can be so complex they can’t be chemically manufactured, limiting their use and affordability. This project aims to develop an inducible system that confers hyper-elev ....Inducible hyper-expression as a tool for metabolic engineering. This project aims to develop methods to improve plant natural products yields and diversify the products manufactured from a wide array of plant species. Valuable plant metabolites, including chemotherapeutics and opiates, are usually synthesised in minute amounts and can be so complex they can’t be chemically manufactured, limiting their use and affordability. This project aims to develop an inducible system that confers hyper-elevated levels of gene expression and independent control of multiple genes involved in metabolite synthesis in the same host. This technology is expected to enable flexible multi-trait bio-factories to be developed.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC210100047
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre for Accelerated Future Crop Development . The Centre will create a new generation of leaders in the implementation of advanced gene and field technologies for the benefit of the Australian agriculture industry. We will build the workforce and foundations that will drive translation of breakthroughs in advanced breeding, phenotyping and genetic technologies into higher-yielding crops. This will increase productivity across the sector and create new markets. Our technical trai ....ARC Training Centre for Accelerated Future Crop Development . The Centre will create a new generation of leaders in the implementation of advanced gene and field technologies for the benefit of the Australian agriculture industry. We will build the workforce and foundations that will drive translation of breakthroughs in advanced breeding, phenotyping and genetic technologies into higher-yielding crops. This will increase productivity across the sector and create new markets. Our technical training programs for graduates, trainees and industry will interface with best evidence-based practices in the wider socio-economic, regulatory and environmental contexts. Coupled with community and stakeholder engagement, the Centre will redefine and secure Australia’s future in agriculture. Read moreRead less
Co-evolution of the host pathogen interaction between Leptosphaeria maculans and Brassica species. Brassica canola is Australia's third largest export crop, producing 13% of the world's canola oil. However, blackleg disease, caused by the fungus Leptospheria maculans leads to annual yield losses of 15%, with 100% loss associated with breakdown of resistance. International investment has provided novel genome resources for Brassica and L. maculans. Applying these resources to understand the co-ev ....Co-evolution of the host pathogen interaction between Leptosphaeria maculans and Brassica species. Brassica canola is Australia's third largest export crop, producing 13% of the world's canola oil. However, blackleg disease, caused by the fungus Leptospheria maculans leads to annual yield losses of 15%, with 100% loss associated with breakdown of resistance. International investment has provided novel genome resources for Brassica and L. maculans. Applying these resources to understand the co-evolution of this plant-fungal interaction could prevent the current boom-bust cycle of canola production in Australia. This study will also provide a model and knowledge base for applications in other species, leading to enhanced crops with increased plant protection and robust, reliable productivity.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101412
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Understanding the biosynthesis of marine UV-absorbing compounds. This project will result in an understanding of the pathways which underpin the ability of marine organisms to avoid stress that occurs due to ongoing climate change. Knowledge gained here will be important for the future protection of coral reefs.
Discovering the activity of novel CLE peptide hormones that regulate legume nodulation. This project aims to functionally characterise novel peptide hormones that regulate the number of nitrogen-fixing root nodules that legumes form. Findings will enhance the current nodulation model and could help to alleviate our reliance on expensive, often polluting, nitrogen-fertilisers by helping to optimise the nodulation process in agriculture.
Discovery of the systemic regulator of legume nodulation. This project aims to discover the novel, shoot-derived factor that legumes produce to regulate the number of nitrogen-fixing root nodules they form. Outcomes will enhance the current nodulation model and could help optimise the process in agriculture, which would help alleviate current reliance on nitrogen-fertilisers that are expensive and pollute.
Discovery Early Career Researcher Award - Grant ID: DE170100151
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Enhancing resistance to wheat stripe rust disease. This project aims to investigate why wheat succumbs to stripe rust fungus, a grave threat to global wheat production. Wheat is the primary agricultural and revenue crop of Australia, cultivated since early European settlement. Severe disease epidemics arise when the fast evolving rust pathogen breaks down host plant genetic resistance. This project will investigate the molecular mechanisms of host-pathogen recognition and the consequences of pat ....Enhancing resistance to wheat stripe rust disease. This project aims to investigate why wheat succumbs to stripe rust fungus, a grave threat to global wheat production. Wheat is the primary agricultural and revenue crop of Australia, cultivated since early European settlement. Severe disease epidemics arise when the fast evolving rust pathogen breaks down host plant genetic resistance. This project will investigate the molecular mechanisms of host-pathogen recognition and the consequences of pathogen variation to determine the causes of resistance breakdown. The expected outcome is robust rust-resistant wheat cultivars to maintain global food security.Read moreRead less
ARC Centre of Excellence in Plant Cell Wall Biology. The ARC Centre for Plant Cell Wall Biology will define the regulatory mechanisms that control molecular, enzymic and cellular processes involved in the synthesis, deposition, re-modelling and depolymerisation of cell wall polysaccharides of cereals and grasses. Plant cell walls represent the world's largest renewable carbon resource, but the regulatory mechanisms responsible for their synthesis and assembly are not understood. Key distinguishi ....ARC Centre of Excellence in Plant Cell Wall Biology. The ARC Centre for Plant Cell Wall Biology will define the regulatory mechanisms that control molecular, enzymic and cellular processes involved in the synthesis, deposition, re-modelling and depolymerisation of cell wall polysaccharides of cereals and grasses. Plant cell walls represent the world's largest renewable carbon resource, but the regulatory mechanisms responsible for their synthesis and assembly are not understood. Key distinguishing features of the Centre will be the international, integrative, and multidisciplinary approach towards addressing major questions in plant biology, its strategy to leverage ARC funding, and its linkages with potential national and international end-users of the fundamental scientific discoveries.Read moreRead less
Genomic strategies for reducing losses during processing and improving the nutritional value of wheat in human diets. Wheat breeding requires efficient tools to allow selection of varieties with both high grain yield and good functional and nutritional value. Whole genome analysis will be used to develop screening methods to deliver wheat varieties with novel processing and nutritional properties for human diets contributing to global food and nutritional security.
Mediator: a new concept for controlled gene expression in plant biotechnology. The Mediator protein complex is a new control point for the activation of all genes in higher organisms and the purpose of this project is to understand how three Mediator subunits regulate disease resistance in plants. The outcomes provide a new concept to direct natural gene expression towards robust crop plants able to cope with climatic variations.