Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$15,780,848.00
Summary
This program focuses on understanding the development of immune response to viruses and other infectious agents using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune diseases like diabetes.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989226
Funder
Australian Research Council
Funding Amount
$340,000.00
Summary
Multi-photon imaging for infection, immunity, and self recognition. This proposal will address a gap in our imaging capabilities, allowing us to visualise the movement of immune cells and infectious agents such as bacteria and viruses within living tissues. This will immensely improve our capacity to understand interactions between the immune system, invading organisms and the rest of our body. The intravital imaging system will provide novel insights into how the immune system works, which will ....Multi-photon imaging for infection, immunity, and self recognition. This proposal will address a gap in our imaging capabilities, allowing us to visualise the movement of immune cells and infectious agents such as bacteria and viruses within living tissues. This will immensely improve our capacity to understand interactions between the immune system, invading organisms and the rest of our body. The intravital imaging system will provide novel insights into how the immune system works, which will benefit the design of vaccines, the treatment of cancer, and our understanding of allergy. This state-of-the-art facility will also provide vital training in an emerging technology that will have application in many areas of biology.
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Compartmental Analysis Of T-cell Responses In Thoracic Malignancies
Funder
National Health and Medical Research Council
Funding Amount
$851,403.00
Summary
To improve immune therapy for cancer we have to be able to determine how cancer patients ‘see’ mutated cancer proteins. Blood is the easiest & most useful source of immune ‘killer’ cells for that task, but the lymph node that drains the tumour and the fluid that bathes a tumour probably contain a much higher number of these killer cells than blood. If so, studying them would help us better track responses to therapy and enable us to choose the best mutated proteins for a vaccine.
Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are a major problem for Australian Indigenous people. Accurate diagnosis of ARF allows for early preventive therapy with long acting penicillin, which can prevent RHD from developing or worsening. The aim of this study is to recruit a cohort of children and young people with ARF and apply the latest technologies to their blood samples, with the aim of developing a diagnostic test and open leads for potential new treatments.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100001
Funder
Australian Research Council
Funding Amount
$875,000.00
Summary
A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected out ....A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected outcomes to include the generation of new knowledge of major biological systems, including the immune system and the nervous system. This will provide significant benefits to fundamental interdisciplinary research into immunology, infectious disease, neuroscience, mechanobiology and engineering.Read moreRead less
CCC method: new applications to electron scattering from atoms and molecules. Achievement of the stated aims will be of enormous benefit to industry
and laboratory research because at the present time no reliably accurate
models exist for the range of the required scattering parameters. The
modelling work will result in development of new software packages for
supercomputers and will provide training for research associates, PhD
and Honours students in an area where Australian theorists are ....CCC method: new applications to electron scattering from atoms and molecules. Achievement of the stated aims will be of enormous benefit to industry
and laboratory research because at the present time no reliably accurate
models exist for the range of the required scattering parameters. The
modelling work will result in development of new software packages for
supercomputers and will provide training for research associates, PhD
and Honours students in an area where Australian theorists are
preeminent.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0238631
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Ultra High Resolution Electron Recycling Spectrometer. Electron collisions with atoms and molecules provide enormous versatility through the transfer of large amounts of angular momentum and the ability to excite dipole forbidden states. However a lack of energy resolution severely restricts the processes that can be studied.
We propose to construct a unique, ultra-high resolution, electron recycling spectrometer using a radical new design. State-of-the-art spectroscopic studies of ato ....Ultra High Resolution Electron Recycling Spectrometer. Electron collisions with atoms and molecules provide enormous versatility through the transfer of large amounts of angular momentum and the ability to excite dipole forbidden states. However a lack of energy resolution severely restricts the processes that can be studied.
We propose to construct a unique, ultra-high resolution, electron recycling spectrometer using a radical new design. State-of-the-art spectroscopic studies of atoms and molecules will be enabled, including the dynamics of near-threshold processes, the formation of transient states and the examination of processes such as rotational excitation and dissociative attachment in molecules - important in a number of gas-discharge based devices.
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A complete computational approach to electron-atom collisions. Our research contributes to multidisciplinary efforts to improve the efficiency and reduce the toxicity of lighting systems, which has far-reaching implications for environmental sustainability. It will also facilitate significant improvements in the accuracy of astrophysical and artificial plasma modelling, as well as providing insight into many processes fundamental to nanotechnology research. The research project will further enha ....A complete computational approach to electron-atom collisions. Our research contributes to multidisciplinary efforts to improve the efficiency and reduce the toxicity of lighting systems, which has far-reaching implications for environmental sustainability. It will also facilitate significant improvements in the accuracy of astrophysical and artificial plasma modelling, as well as providing insight into many processes fundamental to nanotechnology research. The research project will further enhance our reputation in an area where Australian theorists are preeminent, and the research training will produce PhD graduates with a high-level ability in numerical modelling using supercomputers. Such skills are essential in many defense, mining and technological applications of national priority.Read moreRead less
Electronic and atomic collision theory. Recently there has been rapid progress in the field of electronic and atomic collisions. Consequently, many new problems have emerged of interest to science and industry. The proposed collaboration will determine the most promising theoretical techniques for their solution. The problems include, for example, electron
collisions with noble gases, cesium and mercury, of interest to the laser, lighting and plasma processing industries. Time-dependent and tim ....Electronic and atomic collision theory. Recently there has been rapid progress in the field of electronic and atomic collisions. Consequently, many new problems have emerged of interest to science and industry. The proposed collaboration will determine the most promising theoretical techniques for their solution. The problems include, for example, electron
collisions with noble gases, cesium and mercury, of interest to the laser, lighting and plasma processing industries. Time-dependent and time independent, relativistic and non-relativistic approaches will be considered, thereby determining the direction of the field for the foreseeable future.Read moreRead less
Atomic Collision Theory. Collisions between atomic particles are ever-present in astrophysical and man-made plasmas. Their understanding is vital for both fundamental science and industrial applications. The project will develop underlying scattering theory to solve new and outstanding problems in the field. These range from the fundamental problems of electron- or proton-impact ionisation of hydrogen through to collisions involving targets of interest to astrophysics, fusion, X-ray lasers and t ....Atomic Collision Theory. Collisions between atomic particles are ever-present in astrophysical and man-made plasmas. Their understanding is vital for both fundamental science and industrial applications. The project will develop underlying scattering theory to solve new and outstanding problems in the field. These range from the fundamental problems of electron- or proton-impact ionisation of hydrogen through to collisions involving targets of interest to astrophysics, fusion, X-ray lasers and the lighting industry. The theory will also be extended to atom-surface interactions. The understanding of collisions between atomic particles and surfaces will support emerging fields of nanoscience and quantum computing.
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