Atomic scale ion microscopy via laser cooling and correlated imaging. This project will develop next-generation focused ion beam microscopy and nanofabrication using a novel cold ion source based on photoionisation of a laser-cooled atom beam. The low temperature and complex internal state structure of the constituent atoms combine to allow generation of ions with unprecedented brightness and resolution. We will use three unique and innovative ideas: field ionisation of atoms in so-called 'excep ....Atomic scale ion microscopy via laser cooling and correlated imaging. This project will develop next-generation focused ion beam microscopy and nanofabrication using a novel cold ion source based on photoionisation of a laser-cooled atom beam. The low temperature and complex internal state structure of the constituent atoms combine to allow generation of ions with unprecedented brightness and resolution. We will use three unique and innovative ideas: field ionisation of atoms in so-called 'exceptional' states to reduce chromatic aberration; electron-ion correlations to enhance control of the ions at the nanoscale; and atom-atom interactions to isolate and manipulate individual ions. The new technology will enable advances in semiconductor nanofabrication and material characterisation.Read moreRead less
Atomic scale imaging with high coherence electrons and ions. This project aims to combine a cold atom electron-ion source with a commercial microscope column for atomic-scale imaging in biosciences and materials science. Nanoscale imaging with electron and ion microscopy are tools for investigating the world at the atomic scale, underpinning development in modern technologies from semiconductor devices to medical treatments. This project will use ideas from laser cooling of atoms and atom optics ....Atomic scale imaging with high coherence electrons and ions. This project aims to combine a cold atom electron-ion source with a commercial microscope column for atomic-scale imaging in biosciences and materials science. Nanoscale imaging with electron and ion microscopy are tools for investigating the world at the atomic scale, underpinning development in modern technologies from semiconductor devices to medical treatments. This project will use ideas from laser cooling of atoms and atom optics to achieve new imaging modalities for time-lapse imaging of fundamental processes at the nano-scale. It will allow increasingly small scale resolution of fundamental processes at the nano-scale.Read moreRead less
High resolution ultrafast imaging with cold electrons. This project will develop atomic-scale imaging that is able to bypass the resolution limitations of modern electron microscopes. The project will investigate the physical processes underlying a new imaging source based on extracting cold electrons from laser-cooled atoms. Ultrashort pulses of cold electrons will enable time-lapse imaging of fundamental processes at the nano-scale, with applications in fundamental biosciences and materials sc ....High resolution ultrafast imaging with cold electrons. This project will develop atomic-scale imaging that is able to bypass the resolution limitations of modern electron microscopes. The project will investigate the physical processes underlying a new imaging source based on extracting cold electrons from laser-cooled atoms. Ultrashort pulses of cold electrons will enable time-lapse imaging of fundamental processes at the nano-scale, with applications in fundamental biosciences and materials science.Read moreRead less
Investigating the molecular mechanisms underlying non-visual photoreception and their implications in the treatment of human neurological disease. The ability of organisms to detect light is fundamental for survival and has been a major driver in evolution. The project will investigate the genetic origins of the various visual and non-visual systems and will explore its implications for the bioengineering of therapeutics for the treatment of neurological disease in humans.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100100
Funder
Australian Research Council
Funding Amount
$440,000.00
Summary
Cytometer by Time of Flight (CyTOF): A New Paradigm in Cytometry. Cytometer by Time of Flight (CyTOF) - a new paradigm in cytometry: The acquisition of a Cytometer by Time of Flight will allow multiparametric characterisation of biological systems and quantitative analysis of nano-bio interactions at the single cell level. The convergence of nanotechnology with biomedicine offers unprecedented opportunities for biological applications, including targeted therapeutics. One of the major challenges ....Cytometer by Time of Flight (CyTOF): A New Paradigm in Cytometry. Cytometer by Time of Flight (CyTOF) - a new paradigm in cytometry: The acquisition of a Cytometer by Time of Flight will allow multiparametric characterisation of biological systems and quantitative analysis of nano-bio interactions at the single cell level. The convergence of nanotechnology with biomedicine offers unprecedented opportunities for biological applications, including targeted therapeutics. One of the major challenges lies in understanding the complex interactions between nanoengineered materials and biological systems.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100666
Funder
Australian Research Council
Funding Amount
$373,536.00
Summary
Quantum metrology with strongly correlated Rydberg gases. The project aims to make the world's most sensitive measurement of high-frequency electric fields, and demonstrate the first quantum-enhanced electric field measurement. It will use quantum entanglement and Rydberg atoms, excited to the very edge of the classical/quantum divide, to reach record sensitivities for fields associated with next generation ultrafast electronic, communication and radar devices. The project aims to build on the e ....Quantum metrology with strongly correlated Rydberg gases. The project aims to make the world's most sensitive measurement of high-frequency electric fields, and demonstrate the first quantum-enhanced electric field measurement. It will use quantum entanglement and Rydberg atoms, excited to the very edge of the classical/quantum divide, to reach record sensitivities for fields associated with next generation ultrafast electronic, communication and radar devices. The project aims to build on the existing Australian research strengths in photonics, atomic physics and quantum sensing, with the potential to provide a disruptive technological breakthrough in the measurement of ultra-high-frequency electric fields, and establish a high profile research effort in the field of strongly correlated quantum gases.Read moreRead less
Molecular movies using time-resolved momentum spectroscopies. This project aims to use time-resolved momentum spectroscopies to take snapshots of chemical and physical processes as they evolve in time. This project expects to use these molecular movies to track the changes to electron motion after they have absorbed light. Expected outcomes of this project include understanding how the motion of electrons can drive physical processes and induce chemical changes. This will provide significant ben ....Molecular movies using time-resolved momentum spectroscopies. This project aims to use time-resolved momentum spectroscopies to take snapshots of chemical and physical processes as they evolve in time. This project expects to use these molecular movies to track the changes to electron motion after they have absorbed light. Expected outcomes of this project include understanding how the motion of electrons can drive physical processes and induce chemical changes. This will provide significant benefits through expanding knowledge that will assist in controlling chemical reactions and developing technologies with improved performance, such as sensors and solar cells. Read moreRead less
Auger, Quantum Electro-Dynamics, Axions and New Technology. New technology developed by Australia, Sweden and the United States will be applied to major questions about the application of relativistic quantum mechanics to atomic structure and dynamics and spectroscopy, especially including critical issues in quantum electro-dynamics for atomic physics and applications. Discrepancies in quantum electro-dynamics have dominated international debate for decades, with claimed explanations annually fa ....Auger, Quantum Electro-Dynamics, Axions and New Technology. New technology developed by Australia, Sweden and the United States will be applied to major questions about the application of relativistic quantum mechanics to atomic structure and dynamics and spectroscopy, especially including critical issues in quantum electro-dynamics for atomic physics and applications. Discrepancies in quantum electro-dynamics have dominated international debate for decades, with claimed explanations annually failing to reveal the cause. Also a pattern of discrepancies has been seen at X-ray energies in first row metal atoms, with a similar sign and magnitude. A combined experimental an theoretical investigation will aim to reveal new light on these anomalies and serve to develop our understanding of the universe.Read moreRead less
Gene regulation by retroelement encoded natural antisense transcripts. Genetic information underpins all life on earth and is processed to make proteins, which determine the characteristics of an organism. However, only about 2% of our whole genome is made up of genes that encode proteins; the other 98% is non-coding and its function remains poorly understood. Aims and Significance: This proposal aims to utilise cutting edge genomic technologies to generate new knowledge about how the non-coding ....Gene regulation by retroelement encoded natural antisense transcripts. Genetic information underpins all life on earth and is processed to make proteins, which determine the characteristics of an organism. However, only about 2% of our whole genome is made up of genes that encode proteins; the other 98% is non-coding and its function remains poorly understood. Aims and Significance: This proposal aims to utilise cutting edge genomic technologies to generate new knowledge about how the non-coding genome regulates the expression of protein coding genes. Expected Outcomes and Benefits: This proposal will provide novel targets and methodology for gene modulation with broad applications from biology to environmental sciences.Read moreRead less
Investigating a novel, physical adjuvant for improving immune responses of vaccines. This project will explore a new way to significantly improve vaccine immune responses: with practical devices that apply pressure on the skin - for the body to create its own, localised adjuvant. This is novel - completely different to today's adjuvants, which are chemicals put into our bodies.