Virus and host genes and the outcome of infection. Viruses cause infection of all animals including people and the outcome of infection is highly variable. This project aims to use genetics to explain why some animals are more susceptible to particular virus infections and some strains of virus cause more severe diseases. The project will also explore whether all cells are similarly susceptible to killing by viruses.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100020
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
Collaborative high bio-containment immunological research facility. Emerging infectious diseases are a serious threat to animals and humans, with most new human infections originating in animals. Our capacity to study these infections and their effects on the immune system is limited. This Facility will provide core equipment for analysis of immune responses to infection at the highest levels of bio-containment.
The natural function and evolution of an essential parasite transporter. This project aims to resolve the natural function and evolution of a transporter essential to the survival of malaria and other parasites. Malaria and its sibling Apicomplexan parasites cause devastating diseases in humans and livestock across the world. Much remains to be understood about these parasites, and options for controlling them are diminishing. The project will interrogate the functions of the transporter protein ....The natural function and evolution of an essential parasite transporter. This project aims to resolve the natural function and evolution of a transporter essential to the survival of malaria and other parasites. Malaria and its sibling Apicomplexan parasites cause devastating diseases in humans and livestock across the world. Much remains to be understood about these parasites, and options for controlling them are diminishing. The project will interrogate the functions of the transporter proteins. The knowledge gained might help to combat Apicomplexan parasites by targeting these transporters’ native functions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100193
Funder
Australian Research Council
Funding Amount
$590,000.00
Summary
Next Generation Mass Spectrometry for Analysis of Biomolecules. Next-generation mass spectrometry for analysis of biomolecules:
This project seeks to establish a next-generation mass spectrometer that represents the most sensitive, accurate and rapid mass spectrometer allowing the simultaneous quantitation of several hundred to several thousand proteins in a single experiment. This is designed to particularly support infection and immunity research. Novel fragmentation capabilities and enhanced ....Next Generation Mass Spectrometry for Analysis of Biomolecules. Next-generation mass spectrometry for analysis of biomolecules:
This project seeks to establish a next-generation mass spectrometer that represents the most sensitive, accurate and rapid mass spectrometer allowing the simultaneous quantitation of several hundred to several thousand proteins in a single experiment. This is designed to particularly support infection and immunity research. Novel fragmentation capabilities and enhanced workflows on this instrument may allow new types of experiments to be conducted providing significant improvements in coverage and depth of analysis.Read moreRead less
Harnessing the potential of metals in biocatalysis. The project aims to use an integrated, multi-disciplinary approach to study the properties of a group of related but functionally diverse enzymes; binuclear metallohydrolases (BMHs). These enzymes are of great relevance to protein engineers aiming to produce potent agents for bioremediation and pharmacologists interested in developing drugs. Elucidating and modulating the mode of action of BMHs is thus our main objective and should provide esse ....Harnessing the potential of metals in biocatalysis. The project aims to use an integrated, multi-disciplinary approach to study the properties of a group of related but functionally diverse enzymes; binuclear metallohydrolases (BMHs). These enzymes are of great relevance to protein engineers aiming to produce potent agents for bioremediation and pharmacologists interested in developing drugs. Elucidating and modulating the mode of action of BMHs is thus our main objective and should provide essential information to fully exploit the potential of these enzymes for practical applications. In particular, understanding how metal ions interact with BMHs and how this contributes to their reactivity is crucial to optimally understand their biotechnological potential.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100078
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Establishment of a comprehensive regional biophysical analysis facility. Interactions between molecules are needed for cells to function correctly. This facility will permit comprehensive molecular characterisation as well as research into the fundamentals of how molecules interact.