Computational methods in atomic collision theory. We will develop computational methods for solving interactions between particles on the atomic scale. Computational problems, of particular interest to the industry partner, are the treatment of large-scale ill-conditioned linear systems, and the extension of the Gaussian molecular structure package to collision physics. We have been world-leaders in the field of atomic collision theory for almost a decade, and now, utilising the latest software ....Computational methods in atomic collision theory. We will develop computational methods for solving interactions between particles on the atomic scale. Computational problems, of particular interest to the industry partner, are the treatment of large-scale ill-conditioned linear systems, and the extension of the Gaussian molecular structure package to collision physics. We have been world-leaders in the field of atomic collision theory for almost a decade, and now, utilising the latest software and hardware, will have the capacity to extend the numerical techniques to a vast range of collision systems of interest to science and industry, where visualisation and sheer computer power will play a major role in both
code development and production runs.Read moreRead less
Genome editing to improve the dietary quality of potato. The project aims to develop non-genetically modified (non-GM) potato varieties with lower glycaemic index (GI) but good agronomic and culinary traits. Potato is the world's fourth-most important food. It is integral to the western diet and consumption is rising rapidly in Asia. However, the starch in cooked potato is readily digestible causing a rapid elevation of blood sugar levels on eating (i.e. it has a high GI). Long-term consumption ....Genome editing to improve the dietary quality of potato. The project aims to develop non-genetically modified (non-GM) potato varieties with lower glycaemic index (GI) but good agronomic and culinary traits. Potato is the world's fourth-most important food. It is integral to the western diet and consumption is rising rapidly in Asia. However, the starch in cooked potato is readily digestible causing a rapid elevation of blood sugar levels on eating (i.e. it has a high GI). Long-term consumption of meals with high GI is associated with increased risk of obesity, type-2 diabetes and cardiovascular disease. This project aims to use new genome editing methods to silence key genes that influence starch composition and thus develop non-GM potato varieties with lower GI to reduce these risks.Read moreRead less
A Cost-Effective System for Monitoring Lightning Strikes Across Australasia. Lightning causes many major fires in Australia, and rural fire managers would benefit from access to lighting data. Lightning data have been prohibitively expensive because acquiring them requires a dense monitoring network. Low Frequency Electromagnetic Research Ltd (LF*EM) has developed an alternative, cost-effective technology for monitoring lightning based on a sparse network of stations monitoring VLF radiation. We ....A Cost-Effective System for Monitoring Lightning Strikes Across Australasia. Lightning causes many major fires in Australia, and rural fire managers would benefit from access to lighting data. Lightning data have been prohibitively expensive because acquiring them requires a dense monitoring network. Low Frequency Electromagnetic Research Ltd (LF*EM) has developed an alternative, cost-effective technology for monitoring lightning based on a sparse network of stations monitoring VLF radiation. We propose to translate LF*EM's basic science results into a product that can deliver lightning data to fire managers and other users across Oceania.Read moreRead less
Molecular characterisation of the fungal disease defence response in tropical sandalwood (Santalum album). The tropical sandalwood industry in Australia is a highly profitable and expanding enterprise; however this cannot be taken for granted. Fungal diseases in tropical plantations are of increasing concern to growers and left unchecked could result in substantial economic loss and an unsustainable industry. This research seeks to understand the defence response of the tree in order to develop ....Molecular characterisation of the fungal disease defence response in tropical sandalwood (Santalum album). The tropical sandalwood industry in Australia is a highly profitable and expanding enterprise; however this cannot be taken for granted. Fungal diseases in tropical plantations are of increasing concern to growers and left unchecked could result in substantial economic loss and an unsustainable industry. This research seeks to understand the defence response of the tree in order to develop tools to combat fungal disease by rapid selection of highly resistant trees. Essential oil production is also linked to the defence response. Understanding this response as well as exploring chemical means of increasing both disease resistance and oil production will deliver a substantial economic benefit to the expanding tropical sandalwood industry.Read moreRead less
Functional network analysis of plant metabolism in response to salinity and temperature through targeted proteomics. This project will measure changes in plant metabolism and provide methods and a pipeline for quantification and modelling. It will assess nitrogen linked metabolism under environmental stress experienced in Australian wheat cropping systems and build fundamental knowledge of changes in networks of nitrogen metabolism in model plants.
Development of Nuclear Quadrupole Resonance Methods and Technology to Enhance the Detection of Explosives and Other Contraband. This project will develop new methods and technology for the detection of explosives and other compounds using Nuclear Quadrupole Resonance. This technique is of great importance to aviation security and the military and is particularly relevant to the priority goal of 'Safeguarding Australia'. The Industry partner has licensing contracts with major x-ray manufacturer ....Development of Nuclear Quadrupole Resonance Methods and Technology to Enhance the Detection of Explosives and Other Contraband. This project will develop new methods and technology for the detection of explosives and other compounds using Nuclear Quadrupole Resonance. This technique is of great importance to aviation security and the military and is particularly relevant to the priority goal of 'Safeguarding Australia'. The Industry partner has licensing contracts with major x-ray manufacturers and system integrators to integrate this technology. These investigations should yield improvements in the signal to noise ratio, false alarm rates and the spatial discrimination of targets. This work will lead to significant increases in the value of the technology and open up new areas of commercialization.Read moreRead less
Conservation genetics of humpback whales off Western Australia: Implications for the management of the Antarctic Group IV population. We will define the geographic structuring and gene flow of humpback whales comprising Antarctic Area Group IV, and which migrate off the coast of Western Australian. With this information we will develop guidelines for commonwealth, state, industry, and non-government organisations, for conserving and managing discrete (genetic) populations of humpback whales off ....Conservation genetics of humpback whales off Western Australia: Implications for the management of the Antarctic Group IV population. We will define the geographic structuring and gene flow of humpback whales comprising Antarctic Area Group IV, and which migrate off the coast of Western Australian. With this information we will develop guidelines for commonwealth, state, industry, and non-government organisations, for conserving and managing discrete (genetic) populations of humpback whales off Western Australia. We can then manage these cetaceans at the appropriate geographic scale, and assign conservation priority in relation to population genetic structure gained from this study.Read moreRead less
In vitro expression of macrocyclic peptides. This project aims to develop a novel strategy for the production of polypeptides with unnatural chemical groups using a sense codon reassignment approach. Novel peptides could be used in a range of pharmaceutical applications. Peptides made of 20 natural amino acids cover only a very small fraction of the available chemical and functional space. While a peptide’s functionality can be extended with unnatural amino acids, the methods for their site-sele ....In vitro expression of macrocyclic peptides. This project aims to develop a novel strategy for the production of polypeptides with unnatural chemical groups using a sense codon reassignment approach. Novel peptides could be used in a range of pharmaceutical applications. Peptides made of 20 natural amino acids cover only a very small fraction of the available chemical and functional space. While a peptide’s functionality can be extended with unnatural amino acids, the methods for their site-selective incorporation are inefficient. The project’s strategy relies on the depletion of selected tRNAs from an in vitro protein translation system and their replacement with synthetic tRNAs, charged with unnatural amino acids. It is expected that the developed technology could be used to rapidly generate and screen highly diversified macrocyclic peptide libraries.Read moreRead less
Physiology and genetics of barley grain germination in the malting and brewing industries. An international research team will provide new scientific information on barley grain germination. This detailed basic knowledge will be immediately applied in breeding programs that are aimed at improving malting and brewing quality in a commercial context. At the same time, the industry's carbon footprint will be significantly reduced.
Membrane transporters mediating 2,4-D resistance in wild radish. This project aims to identify the membrane transporter protein(s) that endows resistance to the herbicide 2,4-D in wild radish (Raphanus raphanistrum). Wild radish is a particular problem in Australia due to its high competitiveness with crops and widespread resistance to other herbicides. 2,4-D resistance is rapidly increasing and threatening crop production in Australia and the United States. The anticipated outcome of the projec ....Membrane transporters mediating 2,4-D resistance in wild radish. This project aims to identify the membrane transporter protein(s) that endows resistance to the herbicide 2,4-D in wild radish (Raphanus raphanistrum). Wild radish is a particular problem in Australia due to its high competitiveness with crops and widespread resistance to other herbicides. 2,4-D resistance is rapidly increasing and threatening crop production in Australia and the United States. The anticipated outcome of the project is to identify strategies to minimise 2,4-D resistance in wild radish by interfering with the specific transporters that confer resistance and by taking advantage of the fitness cost associated with resistance in some populations. It is expected that this will help to improve crop yields and preserve 2,4-D as an effective herbicide.Read moreRead less