High-throughput microfluidic approach to mapping hierarchies of interactions in the gene regulation machinery. The exploration of protein-protein interactions networks is becoming an extremely active area of research in life sciences. The current project will develop new approaches to accelerate the discovery of novel interacting proteins participating in gene regulation, in order to understand how cells differentiate into different tissues and organs.
Single-molecule optofluidics: streamlining high-throughput engineering and analysis of proteins and protein assemblies. This project aims at creating novel technologies for high-throughput engineering and analysis of proteins with single-molecule sensitivity. The platform will considerably accelerate the generation of protein-based diagnostics, new vaccines and therapeutics; it will foster collaborations with industry putting Australia at the forefront of protein research.
Optimising Intervention Strategies To Reduce The Burden Of Group A Streptococcus In Aboriginal Communities
Funder
National Health and Medical Research Council
Funding Amount
$856,896.00
Summary
Skin sores are highly prevalent in remote Australian Indigenous communities and can lead to invasive infections and rheumatic heart disease. We will develop mathematical models to understand the transmission of skin sores, allowing us to define the optimal extent (household, community, region), timing and triggers for interventions to interrupt transmission. This will guide public health policy in reducing the prevalence of skin sores and scabies, and their accompanying disease burden.
A New Approach to Air Traffic Management to Deliver Significantly Reduced Environmental Impact and System-wide Efficiencies. Aviation is often cited as a major contributor to harmful emissions in the upper atmosphere. The primary outcome of this project is the development of tools that will enable aviation industry stakeholders to optimise the deployment of 4-Dimensional User Preferred Trajectories across Australian airspace. It is expected that this will result in significant environmental bene ....A New Approach to Air Traffic Management to Deliver Significantly Reduced Environmental Impact and System-wide Efficiencies. Aviation is often cited as a major contributor to harmful emissions in the upper atmosphere. The primary outcome of this project is the development of tools that will enable aviation industry stakeholders to optimise the deployment of 4-Dimensional User Preferred Trajectories across Australian airspace. It is expected that this will result in significant environmental benefit, through reductions in fuel burn for each flight, and increases in system effectiveness. The project will enable better analysis of Australian aviation environmental effect, whilst at the same time allowing the aviation industry to continue to contribute to Australia's sustainable economic growth. Read moreRead less
ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit ne ....ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit new cell technologies. The Centre will build critical mass and national focus in bioinformatics to generate the human capital and intellectual property that Australia needs to compete in advanced bioscience and biotechnology.Read moreRead less
Optimal management of corrosion and odour problems in sewer systems. Pollutants in wastewater undergo complex changes in sewers, leading to the production and release of odorous and corrosive compounds. Despite major efforts and expenditure by water utilities to mitigate these problems, odorous emissions from sewers are still commonly occurring in urban areas. Furthermore, the value of public assets is significantly diminished due to sewer corrosion, costing hundreds of millions of dollars a yea ....Optimal management of corrosion and odour problems in sewer systems. Pollutants in wastewater undergo complex changes in sewers, leading to the production and release of odorous and corrosive compounds. Despite major efforts and expenditure by water utilities to mitigate these problems, odorous emissions from sewers are still commonly occurring in urban areas. Furthermore, the value of public assets is significantly diminished due to sewer corrosion, costing hundreds of millions of dollars a year in Australia alone. This project is a major joint effort by the Australian water industry and world-leading scientists to generate advanced knowledge and develop effective technologies for optimal odour and corrosion management in sewers, delivering large social, environmental and economic benefits.Read moreRead less
Understanding the Biotransformation Processes in a Sewer System to Achieve Optimal Management. Sewer corrosion and odour emissions are incurring massive costs to the wastewater management authorities. These problems are primarily caused by the hydrogen sulfide produced by the in-sewer biotransformation processes. Through integrating controlled laboratory experiments, extensive field measurement/experiments and advanced computer modelling, the project aims to generate a fundamental understanding ....Understanding the Biotransformation Processes in a Sewer System to Achieve Optimal Management. Sewer corrosion and odour emissions are incurring massive costs to the wastewater management authorities. These problems are primarily caused by the hydrogen sulfide produced by the in-sewer biotransformation processes. Through integrating controlled laboratory experiments, extensive field measurement/experiments and advanced computer modelling, the project aims to generate a fundamental understanding of the in-sewer biotransformation processes, in particular those occurring in sewer biofilms and sediments, and to provide scientific and engineering support to the wastewater authorities to manage their sewers in a more cost-effective way. Emphasis is placed on the integrated sewer and wastewater treatment performance to achieve overall optimal wastewater management.Read moreRead less
Micromechanical modelling of fault gouge dynamics: towards an improved fault constitutive relation. The human and economic costs of geological and other particulate media related problems in Australia are staggering. These include geological hazards (e.g. landslides and earthquakes; the Newcastle earthquake cost around $4 billion and 13 lives), to particulate processes prevalent in Australia's major export industries (e.g. coal export valued at $9.3 billion, iron ore at $3.8 billion, and wheat ....Micromechanical modelling of fault gouge dynamics: towards an improved fault constitutive relation. The human and economic costs of geological and other particulate media related problems in Australia are staggering. These include geological hazards (e.g. landslides and earthquakes; the Newcastle earthquake cost around $4 billion and 13 lives), to particulate processes prevalent in Australia's major export industries (e.g. coal export valued at $9.3 billion, iron ore at $3.8 billion, and wheat at $3.4 billion), to Australia's 810,000 km granular paved road network that costs around $5.5 million per day to maintain. The program will deliver new knowledge and advanced analytical and predictive modelling tools capable of fuelling breakthroughs in earthquake forecasting research and industrial innovations.
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ARC Centre of Excellence - Centre for Antimatter-Matter Studies. While our world is made of matter, all particles have anti-particles and the most abundant is the positron, the electron's antiparticle. It is the "workshop" for most anti-matter studies, particularly for the characterization of materials, including gases, polymers, insulators, thin films and surfaces, as well as the development of new and novel, nano-structured materials. The ARC Centre of Excellence in Antimatter-Matter Studies ....ARC Centre of Excellence - Centre for Antimatter-Matter Studies. While our world is made of matter, all particles have anti-particles and the most abundant is the positron, the electron's antiparticle. It is the "workshop" for most anti-matter studies, particularly for the characterization of materials, including gases, polymers, insulators, thin films and surfaces, as well as the development of new and novel, nano-structured materials. The ARC Centre of Excellence in Antimatter-Matter Studies (CAMS) will bring together key Australian and international scientists to work in this emerging scientific field of antimatter-matter interactions. It will forge a unique and effective scientific team for state-of-the-art studies of the nano-world that underlies many everyday processes and new technologies.Read moreRead less