In depth characterisation of the gamma delta T cell immune synapse. This project aims to comprehensively characterise the activation principles of gamma delta T cells. These cells have an understudied but central role in vertebrate immunity and development. A missing piece of the puzzle is how gamma delta T cells sense stress and how this signal leads to activation. Expected outcomes include the generation of fundamental knowledge in immunology and structural biology. This proposal uses high-ski ....In depth characterisation of the gamma delta T cell immune synapse. This project aims to comprehensively characterise the activation principles of gamma delta T cells. These cells have an understudied but central role in vertebrate immunity and development. A missing piece of the puzzle is how gamma delta T cells sense stress and how this signal leads to activation. Expected outcomes include the generation of fundamental knowledge in immunology and structural biology. This proposal uses high-skilled techniques, including cryo-electron microscopy and single-molecule imaging and holds ancillary benefits to postgraduate students. Anticipated outcomes include influential publications, building a critical mass of expertise in Australia and fostering international collaborations with Australia at the epicentre.Read moreRead less
Experiment-numerical-virtual Generative Design for Nondeterministic Impacts. This project will establish an advanced nondeterministic design methodology to uncover the optimised material properties and 3D printed metastructural capacity in real-time against impact loading. It will develop a rigorous framework that integrates numerical simulation, experiment, and machine learning-based virtual modelling to tackle practical challenges in design and manufacture of impact-proof materials and structu ....Experiment-numerical-virtual Generative Design for Nondeterministic Impacts. This project will establish an advanced nondeterministic design methodology to uncover the optimised material properties and 3D printed metastructural capacity in real-time against impact loading. It will develop a rigorous framework that integrates numerical simulation, experiment, and machine learning-based virtual modelling to tackle practical challenges in design and manufacture of impact-proof materials and structures with intrinsic uncertainties. The generative design-calibration system unifying experimental-numerical-virtual processes will largely reduce the need for repetitive large-scale experimental tests. This project benefits civil, aerospace, automotive, and defence with competitive advantage through technological innovation.Read moreRead less
Overseeing the internet: new paradigms of network measurement. Like the electricity network, the internet is a core infrastructure, and so must be reliable and efficient. A gap in bandwidth supply is like a blackout in terms of lost business and productivity. This project will provide the measurement breakthroughs to ensure that network behaviour can be accurately and comprehensively monitored.
Topological Design of Mechanical Meta-Structures. This project aims to establish a new computational design methodology to address current challenges facing creation of ultralight structures with ultra-high-performance characteristics. The latest technologies in structural topology optimization and its correlated numerical simulation and structural analysis methods will be unified towards an integrated design framework. Expected outcomes include an advanced generative design platform for discove ....Topological Design of Mechanical Meta-Structures. This project aims to establish a new computational design methodology to address current challenges facing creation of ultralight structures with ultra-high-performance characteristics. The latest technologies in structural topology optimization and its correlated numerical simulation and structural analysis methods will be unified towards an integrated design framework. Expected outcomes include an advanced generative design platform for discovering novel geometries to underpin new meta-structure architectures, validated by appropriate fabrication techniques considering their geometric complexity. Such capabilities will benefit defence, civil, aerospace, energy and transport industries that pursue competitive advantage through innovation.Read moreRead less
Boundary Crossing Analysis for Random Processes with Applications to Risk Management. Effective management of environmental, financial and superannuation investment risks is vitally important for Australia. Results of the project will add to the theoretical foundations of risk management and provide new computational tools for specialists working in the areas of financial engineering, insurance, superannuation funds. These tools will assist in improving risk profile evaluation and developing new ....Boundary Crossing Analysis for Random Processes with Applications to Risk Management. Effective management of environmental, financial and superannuation investment risks is vitally important for Australia. Results of the project will add to the theoretical foundations of risk management and provide new computational tools for specialists working in the areas of financial engineering, insurance, superannuation funds. These tools will assist in improving risk profile evaluation and developing new statistical control charts for security monitoring of epidemics, networks intrusions and other potentially dangerous changes. The research will also give Australia a competitive advantage in the area of education related to stochastic processes, mathematical finance, control theory and their applications.Read moreRead less
Fundamental theoretical investigation of the chemomechanical properties of clays. Australia faces significant environmental challenges, one of the most important being soil degradation. The aim of this project is to develop new and state-of-the art mathematical models describing the behaviour of clays in soils. This proposal addresses five fundamental problems in clay soil behaviour that have so far remained unanswered. The primary outcomes of this project will be new theoretical insights into t ....Fundamental theoretical investigation of the chemomechanical properties of clays. Australia faces significant environmental challenges, one of the most important being soil degradation. The aim of this project is to develop new and state-of-the art mathematical models describing the behaviour of clays in soils. This proposal addresses five fundamental problems in clay soil behaviour that have so far remained unanswered. The primary outcomes of this project will be new theoretical insights into the chemomechanical properties of clay soils, so providing the understanding required to intelligently engineer and manage our natural and built environments.Read moreRead less
Investigating the dynamic nature of antibody stability. The aim of the project is to provide insights into the molecular mechanisms of antibody stability. Monoclonal antibodies have transformed the study of biological processes and represent blockbuster therapeutics for cancer and inflammation. Unfortunately, antibodies often display limited stability, which greatly hinders development. Mutations have recently been identified that render human antibodies resistant to aggregation, and high-resolu ....Investigating the dynamic nature of antibody stability. The aim of the project is to provide insights into the molecular mechanisms of antibody stability. Monoclonal antibodies have transformed the study of biological processes and represent blockbuster therapeutics for cancer and inflammation. Unfortunately, antibodies often display limited stability, which greatly hinders development. Mutations have recently been identified that render human antibodies resistant to aggregation, and high-resolution crystal structures are being used to identify function. Intriguingly, preliminary data indicates that the mutations do not affect the native antibody structure, but rather influence dynamic states. The project plans to use a combination of mutagenesis, molecular dynamics simulation and deuterium exchange to study antibody dynamics.Read moreRead less
Electroweak phase transition: A cosmological window to new particle physics. The observed asymmetry between matter and antimatter in the visible universe arguably represents the major challenge to contemporary particle physics and cosmology. This project explores new theoretical, phenomenological and computational aspects of the electroweak phase transition and the generation of the cosmic matter-antimatter asymmetry in the early universe together with their links to new physics that may manifes ....Electroweak phase transition: A cosmological window to new particle physics. The observed asymmetry between matter and antimatter in the visible universe arguably represents the major challenge to contemporary particle physics and cosmology. This project explores new theoretical, phenomenological and computational aspects of the electroweak phase transition and the generation of the cosmic matter-antimatter asymmetry in the early universe together with their links to new physics that may manifest at present and future high-energy colliders and gravitational wave observatories. Read moreRead less
New Physics and the quark/lepton family replication puzzle. This project aims to investigate how new physics impacts on the puzzling threefold replication of the elementary particles known as quarks and leptons; these particles provide the foundations for the structure of atoms. This theory project seeks to do so in the context of a concentrated worldwide experimental program whose objective is to produce hugely more information about the mysterious replication. Expected outcomes include the con ....New Physics and the quark/lepton family replication puzzle. This project aims to investigate how new physics impacts on the puzzling threefold replication of the elementary particles known as quarks and leptons; these particles provide the foundations for the structure of atoms. This theory project seeks to do so in the context of a concentrated worldwide experimental program whose objective is to produce hugely more information about the mysterious replication. Expected outcomes include the construction of new theories that deepen our understanding of elementary particles and their interactions. This should provide significant benefits to intellectual culture and the training of early-career researchers as flexible problem solvers able to innovate in any context in industry or government service.Read moreRead less
Multilayer Graphene Based Anti-Corrosion Polymer Coated Structures. This project aims to develop a novel multilayer graphene/polymer coating for structures exposed to corrosive environment with graphene concentration varying layer-wise to eliminate galvanic corrosion yet maintain all unique advantages owing to graphene inclusion, thus offering a cost-effective design solution with significantly improved anti-corrosion performance and remarkably enhanced safety and durability for structures. Expe ....Multilayer Graphene Based Anti-Corrosion Polymer Coated Structures. This project aims to develop a novel multilayer graphene/polymer coating for structures exposed to corrosive environment with graphene concentration varying layer-wise to eliminate galvanic corrosion yet maintain all unique advantages owing to graphene inclusion, thus offering a cost-effective design solution with significantly improved anti-corrosion performance and remarkably enhanced safety and durability for structures. Expected outcomes of this project include an innovative design, experimental data on corrosion prevention, development of reliable simulation techniques and design procedures for the proposed coating. This should provide huge benefits to Australian civil, offshore and marine engineering industry and national economy.Read moreRead less