Mastering pyrimidine editing in RNA. Many plants and animals can alter their genetic information via RNA (ribonucleic acid) editing, a process that is often essential for the growth and development of the organism. This ability provides accurate control over gene expression and has great potential as a biotechnological tool in agriculture and medicine. RNA editing could be used to switch genes on or off in biotechnological production systems with an unprecedented degree of precision, or to corre ....Mastering pyrimidine editing in RNA. Many plants and animals can alter their genetic information via RNA (ribonucleic acid) editing, a process that is often essential for the growth and development of the organism. This ability provides accurate control over gene expression and has great potential as a biotechnological tool in agriculture and medicine. RNA editing could be used to switch genes on or off in biotechnological production systems with an unprecedented degree of precision, or to correct genetic diseases. This project aims to understand two RNA editing pathways in plants, one of which is found nowhere else and likely to involve a novel enzymatic mechanism. We will use the understanding gained to develop novel RNA processing tools usable in any living organism.Read moreRead less
Ion-atom collision data for fusion energy, hadron therapy and astrophysics. This project aims to combine experimental and theoretical efforts to generate accurate data required for the development and maintenance of fusion reactors, treatment planning in hadron therapy of cancerous tumours, and modelling astrophysical phenomena. Hadron therapy has been used successfully worldwide for over a decade with Australia’s first such facility, the Bragg Centre for Proton Therapy, currently under construc ....Ion-atom collision data for fusion energy, hadron therapy and astrophysics. This project aims to combine experimental and theoretical efforts to generate accurate data required for the development and maintenance of fusion reactors, treatment planning in hadron therapy of cancerous tumours, and modelling astrophysical phenomena. Hadron therapy has been used successfully worldwide for over a decade with Australia’s first such facility, the Bragg Centre for Proton Therapy, currently under construction. Fusion reactors are a source of abundant green energy. Immense progress is being made in their construction and underlying technology. Currently, there is an urgent demand for accurate data on ion-beam collisions with atoms and molecules for the aforementioned applications. This project intends to meet this demand.Read moreRead less
Electron-molecule collisions in fusion and astrophysical plasmas. This project will apply innovative methods developed in Australia to accurately model electron collisions with diatomic hydrides. It will generate new knowledge of the dynamics underlying fundamental chemical reactions, and bring international scientists together to study the influence of molecules in plasmas more accurately than ever before. Outcomes will include essential diagnostics for fusion reactors, methods for using the Ja ....Electron-molecule collisions in fusion and astrophysical plasmas. This project will apply innovative methods developed in Australia to accurately model electron collisions with diatomic hydrides. It will generate new knowledge of the dynamics underlying fundamental chemical reactions, and bring international scientists together to study the influence of molecules in plasmas more accurately than ever before. Outcomes will include essential diagnostics for fusion reactors, methods for using the James Webb Space Telescope to study astrophysical clouds, and strengthened ties between Australia and the global plasma physics community. The significant benefits will include accelerating the development of fusion technology as an alternative to fossil fuels, and furthering our understanding of stellar evolution.Read moreRead less
Antihydrogen formation. This project aims to advance fundamental understanding of collisions involving antimatter. The dominance of matter over antimatter in the Universe is one of the most intriguing questions of today’s science. Researchers at the European Organisation for Nuclear Research (CERN) are addressing this question by creating antihydrogen and studying its properties, including the gravitational behaviour. By trapping and cooling antihydrogen positive ions, ultra-cold antihydrogen at ....Antihydrogen formation. This project aims to advance fundamental understanding of collisions involving antimatter. The dominance of matter over antimatter in the Universe is one of the most intriguing questions of today’s science. Researchers at the European Organisation for Nuclear Research (CERN) are addressing this question by creating antihydrogen and studying its properties, including the gravitational behaviour. By trapping and cooling antihydrogen positive ions, ultra-cold antihydrogen atoms can be created and used in free fall experiments at CERN. The convergent close-coupling method and threshold theory will be used to provide the necessary theoretical guidance for the experimental antihydrogen positive ion formation via low-energy positronium-antiproton and positronium-antihydrogen collisions.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100176
Funder
Australian Research Council
Funding Amount
$349,987.00
Summary
Quantum studies of dissociative electron attachment to molecules. The ability to predict the outcomes of molecular collisions is a difficult, yet important, problem with many applications in science and industry. Recent work at Curtin University has led to the first complete solution of the electronic part of the scattering problem for collisions with the hydrogen molecule, a major breakthrough in the field. This project will build on this progress to accurately model the nuclear motion during c ....Quantum studies of dissociative electron attachment to molecules. The ability to predict the outcomes of molecular collisions is a difficult, yet important, problem with many applications in science and industry. Recent work at Curtin University has led to the first complete solution of the electronic part of the scattering problem for collisions with the hydrogen molecule, a major breakthrough in the field. This project will build on this progress to accurately model the nuclear motion during collisions, which will enable the first calculations of molecular dissociation processes without the use of approximations. The data which will be produced is highly sought-after in fusion energy and astrophysics applications.Read moreRead less
Brain-skull interface: discovering the missing piece of head biomechanics. Overall objective of this project is to measure, mathematically describe and implement in software mechanical properties of brain-skull interface – a critical component of current large and sophisticated computational models of the brain and the last missing piece of brain biomechanics knowledge. This will allow increased reliability of comprehensive biomechanical models used to simulate realistic injury and surgery scena ....Brain-skull interface: discovering the missing piece of head biomechanics. Overall objective of this project is to measure, mathematically describe and implement in software mechanical properties of brain-skull interface – a critical component of current large and sophisticated computational models of the brain and the last missing piece of brain biomechanics knowledge. This will allow increased reliability of comprehensive biomechanical models used to simulate realistic injury and surgery scenarios.
The problem is significant and urgent. Every year in Australia, there are over 22,000 cases of traumatic brain injury, some of which could be prevented by better passive and active countermeasures; and over 12,000 neurosurgical procedures that surgical simulation could make more accurate and therefore safer.Read moreRead less
Electron, positron, and heavy-particle collisions with molecules. This project aims to develop a computational approach to collisions involving molecular targets with electrons, positrons and heavy particles. Recently, the approach to atomic collisions, the Convergent Close Coupling (CCC) method, has been extended and verified for positron, electron, and heavy particle collisions with the simplest molecular systems (molecular hydrogen and its ion). This project now aims to extend the CCC method ....Electron, positron, and heavy-particle collisions with molecules. This project aims to develop a computational approach to collisions involving molecular targets with electrons, positrons and heavy particles. Recently, the approach to atomic collisions, the Convergent Close Coupling (CCC) method, has been extended and verified for positron, electron, and heavy particle collisions with the simplest molecular systems (molecular hydrogen and its ion). This project now aims to extend the CCC method to study collisions with more complex molecules. Expected benefits include more accurate data for diagnostic tools such as Positron Emission Tomography, and potential advances in particle-based cancer therapy.Read moreRead less
Sewer corrosion reduction through model-supported ventilation control. Ventilation is one of the key technologies for sewer corrosion control. However, its design and operation are currently based on experience and empirical equations, often leading to unsatisfactory results. By integrating in-depth laboratory and pilot-sewer studies under defined conditions with extensive field investigations, this multidisciplinary project aims to develop critical models to predict the corrosion process in res ....Sewer corrosion reduction through model-supported ventilation control. Ventilation is one of the key technologies for sewer corrosion control. However, its design and operation are currently based on experience and empirical equations, often leading to unsatisfactory results. By integrating in-depth laboratory and pilot-sewer studies under defined conditions with extensive field investigations, this multidisciplinary project aims to develop critical models to predict the corrosion process in response to ventilation and dynamic wastewater and atmospheric conditions, enabling model-based sewer ventilation design and operation. The project also aims to deliver novel, field-demonstrated ventilation strategies. The project findings will be incorporated in the Australian ventilation design and operation guidelines.Read moreRead less
Resolving the steps in the evolution of C4 photosynthesis. This project aims to identify the molecular mechanisms responsible for the evolution of grasses using the C4 biochemical pathway that enables plants to survive in hot, dry, high-light environments. The endemic Australian subtribe Neurachninae is the only known grass group that contains C4 species, species using the ancestral C3 pathway, as well as species using pathways intermediate to C3 and C4. Through a comparative approach employing ....Resolving the steps in the evolution of C4 photosynthesis. This project aims to identify the molecular mechanisms responsible for the evolution of grasses using the C4 biochemical pathway that enables plants to survive in hot, dry, high-light environments. The endemic Australian subtribe Neurachninae is the only known grass group that contains C4 species, species using the ancestral C3 pathway, as well as species using pathways intermediate to C3 and C4. Through a comparative approach employing high-throughput sequencing technologies, it is expected that the molecular changes underlying the transition from C3 to C4 will be identified. These results should define what is required to engineer plant varieties with increased yield and the ability to withstand climate change effects.Read moreRead less