Co-evolution of the host pathogen interaction between Leptosphaeria maculans and Brassica species. Brassica canola is Australia's third largest export crop, producing 13% of the world's canola oil. However, blackleg disease, caused by the fungus Leptospheria maculans leads to annual yield losses of 15%, with 100% loss associated with breakdown of resistance. International investment has provided novel genome resources for Brassica and L. maculans. Applying these resources to understand the co-ev ....Co-evolution of the host pathogen interaction between Leptosphaeria maculans and Brassica species. Brassica canola is Australia's third largest export crop, producing 13% of the world's canola oil. However, blackleg disease, caused by the fungus Leptospheria maculans leads to annual yield losses of 15%, with 100% loss associated with breakdown of resistance. International investment has provided novel genome resources for Brassica and L. maculans. Applying these resources to understand the co-evolution of this plant-fungal interaction could prevent the current boom-bust cycle of canola production in Australia. This study will also provide a model and knowledge base for applications in other species, leading to enhanced crops with increased plant protection and robust, reliable productivity.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100151
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Enhancing resistance to wheat stripe rust disease. This project aims to investigate why wheat succumbs to stripe rust fungus, a grave threat to global wheat production. Wheat is the primary agricultural and revenue crop of Australia, cultivated since early European settlement. Severe disease epidemics arise when the fast evolving rust pathogen breaks down host plant genetic resistance. This project will investigate the molecular mechanisms of host-pathogen recognition and the consequences of pat ....Enhancing resistance to wheat stripe rust disease. This project aims to investigate why wheat succumbs to stripe rust fungus, a grave threat to global wheat production. Wheat is the primary agricultural and revenue crop of Australia, cultivated since early European settlement. Severe disease epidemics arise when the fast evolving rust pathogen breaks down host plant genetic resistance. This project will investigate the molecular mechanisms of host-pathogen recognition and the consequences of pathogen variation to determine the causes of resistance breakdown. The expected outcome is robust rust-resistant wheat cultivars to maintain global food security.Read moreRead less
A systems approach to dissect the pathogenicity and host specificity of the Fusarium wilt pathogen, Fusarium oxysporum. The pathogenic fungus Fusarium oxysporum causes wilt disease in many plant species, including many that are important for Australian agriculture. Developing environmentally friendly disease protection strategies against this pathogen requires a clear understanding of infection strategies used by the fungus to invade its host. This project, along with a parallel project in host ....A systems approach to dissect the pathogenicity and host specificity of the Fusarium wilt pathogen, Fusarium oxysporum. The pathogenic fungus Fusarium oxysporum causes wilt disease in many plant species, including many that are important for Australian agriculture. Developing environmentally friendly disease protection strategies against this pathogen requires a clear understanding of infection strategies used by the fungus to invade its host. This project, along with a parallel project in host resistance mechanisms, will provide the basis for development of a world leading platform in mechanisms of fungal pathogenicity and virulence and plant disease resistance/susceptibility. Application of the knowledge gained in this project to other host-pathogen interactions will thereby provide opportunities for improved crop protection and biosecurity.Read moreRead less
Mediator: a new concept for controlled gene expression in plant biotechnology. The Mediator protein complex is a new control point for the activation of all genes in higher organisms and the purpose of this project is to understand how three Mediator subunits regulate disease resistance in plants. The outcomes provide a new concept to direct natural gene expression towards robust crop plants able to cope with climatic variations.
A novel link between plant pathogen defence and DNA repair capability. Plants and plant-based industries are essential for the provision of food, clothing and building materials and underpin the economies of rural communities. Plant yield and quality and the biodiversity of natural systems are dramatically reduced by disease. The fundamental knowledge gained from our research will enable manipulation of the factors that enhance disease resistance resulting in a significant benefit to Australian ....A novel link between plant pathogen defence and DNA repair capability. Plants and plant-based industries are essential for the provision of food, clothing and building materials and underpin the economies of rural communities. Plant yield and quality and the biodiversity of natural systems are dramatically reduced by disease. The fundamental knowledge gained from our research will enable manipulation of the factors that enhance disease resistance resulting in a significant benefit to Australian agriculture and protection of our natural resources. The current reliance for disease control on chemicals that damage the environment will be reduced and our research will contribute directly to the provision of cheaper, simpler and more effective methods of control.
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Characterisation of interacting genes that condition avirulence and resistance between Phytophthora pathogens and soybean. Plant pathogens from the genus Phytophthora cause severe crop losses in Australia and worldwide. Resistance in host plants is frequently overcome by mutation of avirulence genes in the pathogen to create virulent new races. We will clone and characterise genes from Phytophthora sojae that control virulence and avirulence, and isolate soybean genes whose products interact w ....Characterisation of interacting genes that condition avirulence and resistance between Phytophthora pathogens and soybean. Plant pathogens from the genus Phytophthora cause severe crop losses in Australia and worldwide. Resistance in host plants is frequently overcome by mutation of avirulence genes in the pathogen to create virulent new races. We will clone and characterise genes from Phytophthora sojae that control virulence and avirulence, and isolate soybean genes whose products interact with the Phytophthora gene products. An understanding of the molecular mechanisms than enable current plant varieties to recognise Phytophthora pathogens leading to resistance or susceptibility will assist the development of novel strategies for durable disease resistance in soybean and other crop plants.Read moreRead less
My enemy’s enemy is my friend: The genetics of major plant pathogen killers. Fungi are devastating agents of crop diseases. These plant pathogens, in turn, are often parasitized by other fungi in the field. The project will focus on such interactions between powdery mildews, important pathogens of many crops and wild plants, and their common fungal parasites (Ampelomyces spp.) that have already been utilised as
biocontrol agents in crop protection. Genetic and genomic tools will be used to deter ....My enemy’s enemy is my friend: The genetics of major plant pathogen killers. Fungi are devastating agents of crop diseases. These plant pathogens, in turn, are often parasitized by other fungi in the field. The project will focus on such interactions between powdery mildews, important pathogens of many crops and wild plants, and their common fungal parasites (Ampelomyces spp.) that have already been utilised as
biocontrol agents in crop protection. Genetic and genomic tools will be used to determine if these parasites evolved by switching host from plants to plant pathogens. The project has the potential to make a ground-breaking discovery in this field, and also establish the starting point for new innovative methods to protect a wide diversity
of crops using these fungi or specific compounds derived from them.Read moreRead less
Discovering the activity of novel CLE peptide hormones that regulate legume nodulation. This project aims to functionally characterise novel peptide hormones that regulate the number of nitrogen-fixing root nodules that legumes form. Findings will enhance the current nodulation model and could help to alleviate our reliance on expensive, often polluting, nitrogen-fertilisers by helping to optimise the nodulation process in agriculture.
Discovery of the systemic regulator of legume nodulation. This project aims to discover the novel, shoot-derived factor that legumes produce to regulate the number of nitrogen-fixing root nodules they form. Outcomes will enhance the current nodulation model and could help optimise the process in agriculture, which would help alleviate current reliance on nitrogen-fertilisers that are expensive and pollute.
Discovery Early Career Researcher Award - Grant ID: DE160101570
Funder
Australian Research Council
Funding Amount
$352,000.00
Summary
Inducible hyper-expression as a tool for metabolic engineering. This project aims to develop methods to improve plant natural products yields and diversify the products manufactured from a wide array of plant species. Valuable plant metabolites, including chemotherapeutics and opiates, are usually synthesised in minute amounts and can be so complex they can’t be chemically manufactured, limiting their use and affordability. This project aims to develop an inducible system that confers hyper-elev ....Inducible hyper-expression as a tool for metabolic engineering. This project aims to develop methods to improve plant natural products yields and diversify the products manufactured from a wide array of plant species. Valuable plant metabolites, including chemotherapeutics and opiates, are usually synthesised in minute amounts and can be so complex they can’t be chemically manufactured, limiting their use and affordability. This project aims to develop an inducible system that confers hyper-elevated levels of gene expression and independent control of multiple genes involved in metabolite synthesis in the same host. This technology is expected to enable flexible multi-trait bio-factories to be developed.Read moreRead less