Characterising genetic variation in Brassica napus. Applying the latest scientific advances supports society through promoting a knowledge based economy, as well as through securing agricultural productivity and biomedical applications. Establishing these methods places Australia at the forefront of genomics technology with direct applications for Australian agricultural, biomedical and biotechnology industries. Maintaining agricultural production in an unreliable environment remains a national ....Characterising genetic variation in Brassica napus. Applying the latest scientific advances supports society through promoting a knowledge based economy, as well as through securing agricultural productivity and biomedical applications. Establishing these methods places Australia at the forefront of genomics technology with direct applications for Australian agricultural, biomedical and biotechnology industries. Maintaining agricultural production in an unreliable environment remains a national challenge, both for rural and urban communities. This technology will provide a detailed understanding of crop genome variation in relation to agronomic traits and lead to the development of crops that are better suited to the Australian climate, supporting a sustainable agricultural industry.Read moreRead less
Novel bioinformatics approaches for biological inference from comparative genomics data. Unlocking the potential of the human and other genome sequences depends almost entirely upon comparative genomics techniques. We will develop powerful bioinformatic models, implemented as high-performance computing solutions, for the examination of gene sequences. Improving these models, which represent the initial building block for all comparative genomics techniques, will be beneficial across genomics dep ....Novel bioinformatics approaches for biological inference from comparative genomics data. Unlocking the potential of the human and other genome sequences depends almost entirely upon comparative genomics techniques. We will develop powerful bioinformatic models, implemented as high-performance computing solutions, for the examination of gene sequences. Improving these models, which represent the initial building block for all comparative genomics techniques, will be beneficial across genomics dependent industries. A major outcome from this work will be an integrated software/hardware product optimised for statistical examination of very large-scale genomics data.Read moreRead less
Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a ....Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a red blood cell line. Simultaneously, this project aims to generate fundamental insights into mechanisms of human gene regulation. The technological and biological outcomes of this project will be of benefit for future gene editing applications.Read moreRead less
Development of molecular markers for resistance to blackleg disease (Leptosphaeria maculans) in canola. Canola (Brassica napus) is a valuable oil seed crop grown in many parts of the world and contributes annually $A450 million to the Australian economy. The overall aim of this project is to develop molecular markers for blackleg resistance using Australian germplasm along with evaluation in Australian disease nurseries which are regarded worlwide to develop the highest levels of disease pressu ....Development of molecular markers for resistance to blackleg disease (Leptosphaeria maculans) in canola. Canola (Brassica napus) is a valuable oil seed crop grown in many parts of the world and contributes annually $A450 million to the Australian economy. The overall aim of this project is to develop molecular markers for blackleg resistance using Australian germplasm along with evaluation in Australian disease nurseries which are regarded worlwide to develop the highest levels of disease pressure. Once molecular marker systems are developed and evaluated, they will be applied to facilitate the selection of Nugrain's (Industry Partner) canola breeding programs. Any molecular markers and QTL developed for Australian cultivars would find commercial application in breeding programmes.Read moreRead less
A community based social identity approach to loneliness. Loneliness across Australia is a deep concern. Social prescribing is a novel community-based approach to managing loneliness, however it is unclear when and in what circumstances it is effective. This project aims to test a social identity approach to loneliness, incorporating longitudinal, cross-sectional, and experimental methods to understand how best to engage isolated people in group programs. The expected benefits of this project ar ....A community based social identity approach to loneliness. Loneliness across Australia is a deep concern. Social prescribing is a novel community-based approach to managing loneliness, however it is unclear when and in what circumstances it is effective. This project aims to test a social identity approach to loneliness, incorporating longitudinal, cross-sectional, and experimental methods to understand how best to engage isolated people in group programs. The expected benefits of this project are to produce a validated social prescribing model that can be implemented in multiple settings across Australia in order to reduce loneliness, strengthen communities, and guide more appropriate uses of health services.Read moreRead less
Social Glue? The contribution of sport and active recreation to community wellbeing. Australian federal, state and local governments allocate more than $4,094 million per year to the provision of sport and recreation services, facilities and programs which service more than 5 million regular participants. This funding is, in part, based on the premise that involvement in sport and recreation develops community wellbeing through the facilitation of social inclusion and connectedness. This researc ....Social Glue? The contribution of sport and active recreation to community wellbeing. Australian federal, state and local governments allocate more than $4,094 million per year to the provision of sport and recreation services, facilities and programs which service more than 5 million regular participants. This funding is, in part, based on the premise that involvement in sport and recreation develops community wellbeing through the facilitation of social inclusion and connectedness. This research will contribute to the development of policies and practices that will enhance the capability of sport and active recreation organisations to contribute to community wellbeing.Read moreRead less
Computational methods in atomic collision theory. We will develop computational methods for solving interactions between particles on the atomic scale. Computational problems, of particular interest to the industry partner, are the treatment of large-scale ill-conditioned linear systems, and the extension of the Gaussian molecular structure package to collision physics. We have been world-leaders in the field of atomic collision theory for almost a decade, and now, utilising the latest software ....Computational methods in atomic collision theory. We will develop computational methods for solving interactions between particles on the atomic scale. Computational problems, of particular interest to the industry partner, are the treatment of large-scale ill-conditioned linear systems, and the extension of the Gaussian molecular structure package to collision physics. We have been world-leaders in the field of atomic collision theory for almost a decade, and now, utilising the latest software and hardware, will have the capacity to extend the numerical techniques to a vast range of collision systems of interest to science and industry, where visualisation and sheer computer power will play a major role in both
code development and production runs.Read moreRead less
Improving Indigenous health and wellbeing over the family life course. Improving Indigenous health and wellbeing over the family life course. This project aims to reduce Indigenous health inequalities, a major social and economic problem, by improving the policy relevant evidence base on the determinants of Indigenous health and wellbeing. This project will compare the impact of the family life course on the health and wellbeing of Indigenous and non-Indigenous mothers and children. It will use ....Improving Indigenous health and wellbeing over the family life course. Improving Indigenous health and wellbeing over the family life course. This project aims to reduce Indigenous health inequalities, a major social and economic problem, by improving the policy relevant evidence base on the determinants of Indigenous health and wellbeing. This project will compare the impact of the family life course on the health and wellbeing of Indigenous and non-Indigenous mothers and children. It will use survey data that follows them over time to: 1) identify family structures that enhance or harm health and wellbeing, and; 2) track changes in health and wellbeing before, during and after family transitions (i.e. births, relationship changes). Anticipated results are better targeted policy interventions to reduce Indigenous health inequalities.Read moreRead less
Bayesian methodology for analysis of genome data with focus on the livestock industry. The aim is to develop statistical methods for the design and analysis of genome data with focus on the special needs of the livestock industry. This will significantly contribute to profitability, quality, genetic improvement and genetic knowledge in a key national industry, improve Australia's international and national profile in the key research area of bioinformatics, and encourage optimisation of current ....Bayesian methodology for analysis of genome data with focus on the livestock industry. The aim is to develop statistical methods for the design and analysis of genome data with focus on the special needs of the livestock industry. This will significantly contribute to profitability, quality, genetic improvement and genetic knowledge in a key national industry, improve Australia's international and national profile in the key research area of bioinformatics, and encourage optimisation of current information. Outcomes include a toolkit of applicable statistical methods, statistically valid algorithms, marketable methods for gene discovery, technology transfer, training and publications.Read moreRead less
Bridging the gap on locational disadvantage: Impact of community-identified interventions on social capital, psychosocial and socioeconomic outcomes. Interventions to combat locational disadvantage are vital given the pervasiveness and long-term consequences for youth and communities. This research will offer important educational and socio-economic benefits by enriching the psychosocial adjustment and life potential of young Australians and the capacity of schools in locationally disadvantaged ....Bridging the gap on locational disadvantage: Impact of community-identified interventions on social capital, psychosocial and socioeconomic outcomes. Interventions to combat locational disadvantage are vital given the pervasiveness and long-term consequences for youth and communities. This research will offer important educational and socio-economic benefits by enriching the psychosocial adjustment and life potential of young Australians and the capacity of schools in locationally disadvantaged communities. Effective research and community-identified social capital and psychosocial interventions will enhance pro-social behaviours, health, psychosocial adjustment, and school and community engagement. This will build capacity at community, school, and individual levelsand contribute to national socioeconomic wellbeing.Read moreRead less