Risk Of Recurrence After Diagnosis Of Invasive Breast Cancer By Molecular Subtype As Defined By ER, PR And Her2 Status
Funder
National Health and Medical Research Council
Funding Amount
$500,622.00
Summary
Breast cancer is a heterogeneous disease. Molecular subtypes have been identified that differ in terms of prognosis and response to treatment. This study aims to estimate recurrence free survival of breast cancer by molecular subtypes in a population-based sample of Australian women. The results will assist clinicians to guide their therapeutic decisions and will inform women about their anticipated outcome after diagnosis of breast cancer.
Novel Molecular Markers Of Lung Cancer Risk And Survival
Funder
National Health and Medical Research Council
Funding Amount
$824,765.00
Summary
Lung cancer remains the most lethal cancer worldwide, yet little is known of the risk factors beyond that of tobacco smoking and certain occupational exposures. We have assembled a large international consortium comprising 24 cohort studies and over 10,000 to validate associations between B-vitamins and lung cancer risk particularly in never and former smokers. We propose to expand this study and use the Melbourne Collaborative Cohort Study and the rest of the consortium to identify novel biomar ....Lung cancer remains the most lethal cancer worldwide, yet little is known of the risk factors beyond that of tobacco smoking and certain occupational exposures. We have assembled a large international consortium comprising 24 cohort studies and over 10,000 to validate associations between B-vitamins and lung cancer risk particularly in never and former smokers. We propose to expand this study and use the Melbourne Collaborative Cohort Study and the rest of the consortium to identify novel biomarkers of risk and survival.Read moreRead less
IMPROVE - Investigating Medication Re-Purposing To Reduce Risk Of OVarian Cancer And Extend Survival
Funder
National Health and Medical Research Council
Funding Amount
$430,196.00
Summary
Ovarian cancer is the 6th most common cause of cancer death in women and the proportion of women who die from their disease has not improved substantially over time. This large-scale study will use de-identified data from the Pharmaceutical Benefits Scheme, the Australian Cancer Database and the National Death Index to investigate whether medications commonly used for other conditions can help decrease the risk of ovarian cancer developing or improve survival from ovarian cancer after diagnosis.
We will conduct a study of more than 500 Australian female twin pairs in which one or both have had breast cancer. We will also study measured and unmeasured genetic and environmental causes of risk factors.
Heritable And Environmental Determinants Of Hospitalisation For Common Childhood Illnesses
Funder
National Health and Medical Research Council
Funding Amount
$468,238.00
Summary
This study will combine the unique and powerful resources of the Western Australian (WA) Data Linkage System and the WA Twin Register to disentangle the effects of genetics and the environment on the most common infectious causes of hospital admissions in children. It will highlight appropriate pathways to prevent such admissions in the future.
Case-Control Study Of Genetic And Environmental Risk Factors For Pancreatic Carcinoma
Funder
National Health and Medical Research Council
Funding Amount
$1,003,411.00
Summary
Pancreatic carcinoma is the fourth most common cause of cancer death in developed countries, and is approximately sixty percent more common in men than in women. In Australia approximately 1800 people are diagnosed with pancreatic cancer each year and there are a similar number of deaths. The five-year survival is less than five percent, and the majority of patients die within the first year. Surgery is frequently not possible due to the advanced stage of disease at diagnosis, and chemotherapy i ....Pancreatic carcinoma is the fourth most common cause of cancer death in developed countries, and is approximately sixty percent more common in men than in women. In Australia approximately 1800 people are diagnosed with pancreatic cancer each year and there are a similar number of deaths. The five-year survival is less than five percent, and the majority of patients die within the first year. Surgery is frequently not possible due to the advanced stage of disease at diagnosis, and chemotherapy is largely ineffective. A better understanding of the causes of pancreatic cancer is essential in order to develop strategies to prevent this lethal cancer. Currently the causes of pancreatic cancer are poorly understood. Family history and smoking probably account for approximately 30% of cases, but for the remainder the cause is unknown. This study will assess a new hypothesis, namely that too much acid in the stomach possibly caused by infection with a bacterial organism, could increase the risk of pancreatic cancer. We will include people who are diagnosed with cancer of the pancreas (cases), and match these to people selected from the electoral roll who have not ever been diagnosed with pancreatic cancer (controls). Participants will be asked a series of detailed questions about their diet, smoking, occupation and medical history. We will collect blood to look for antibodies to the bacteria and to examine specific genes, and we will compare all these factors in cases and controls. This is one of the first large studies of pancreatic cancer in Australia and we will take an integrated approach to examining interactions between genetics and exposure to environmental factors.Read moreRead less
A Population-based Family Study Of Follicular Lymphoma
Funder
National Health and Medical Research Council
Funding Amount
$1,703,070.00
Summary
Annually more than 900 Australians are diagnosed with follicular lymphoma. The proposed research aims identify the environmental and genetic causes of this serious blood cancer. People diagnosed with lymphoma, and a family member, will provide detailed personal and family histories, and a blood sample. Exposure to specific chemicals, types of work, sun exposure, and body size are some of the factors the study will examine. The 5-year study will be conducted in NSW, ACT and Victoria.
Collaborative Australian Renal Cell Carcinoma Epidemiology Study (CARES)
Funder
National Health and Medical Research Council
Funding Amount
$1,677,048.00
Summary
The objective of this project is to increase our knowledge of the causes of renal cell carcinoma, a relatively common, yet understudied, cancer and use this new knowledge to develop a risk prediction tool to provide a rational basis for risk counselling. The proposed project will establish a biobank and generate a research platform that, beyond the duration of the project, will allow us to identify diagnostic and prognostic biomarkers, and therapeutic targets.