Mobile Indonesians: social differentiation and digital literacies in the twenty first century. This is the first dedicated study of the social implications of mobile telephony's recent and rapid popularisation throughout the country. This project will study metropolitan, urban and rural users to understand how mobile phones create the new and unexpected social networks which will shape tomorrow's Indonesians.
Intercultural inquiry in a trans-national context: Exploring the legacy of the 1948 American-Australian Scientific Expedition to Arnhem Land. In terms of National Research Priorities, the project will encourage cultural health and cohesiveness in Arnhem Land by providing access to cultural property held until now in remote archives. It will enhance understanding of our region and the world by studying cross-cultural interactions within Australia. Furthermore, it will illuminate how Aboriginal te ....Intercultural inquiry in a trans-national context: Exploring the legacy of the 1948 American-Australian Scientific Expedition to Arnhem Land. In terms of National Research Priorities, the project will encourage cultural health and cohesiveness in Arnhem Land by providing access to cultural property held until now in remote archives. It will enhance understanding of our region and the world by studying cross-cultural interactions within Australia. Furthermore, it will illuminate how Aboriginal territory and knowledge were used to shore up the Australia-US relationship at a formative historical moment.Read moreRead less
Expedition to Arnhem Land: Intercultural inquiry in a trans-national context. In terms of National Research Priorities, the project will encourage cultural health and cohesiveness in Arnhem Land by providing access to cultural property held until now in remote archives. It will enhance understanding of our region and the world by studying cross-cultural interactions within Australia. Furthermore, it will illuminate how Aboriginal territory and knowledge were used to shore up the Australia-US rel ....Expedition to Arnhem Land: Intercultural inquiry in a trans-national context. In terms of National Research Priorities, the project will encourage cultural health and cohesiveness in Arnhem Land by providing access to cultural property held until now in remote archives. It will enhance understanding of our region and the world by studying cross-cultural interactions within Australia. Furthermore, it will illuminate how Aboriginal territory and knowledge were used to shore up the Australia-US relationship at a formative historical moment.Read moreRead less
ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial ....ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial concepts into statistical analysis and modelling, powerful visualisation of information, and the building spatial decision support systems, to provide an improved evidence base and better informed decision-making to address the significant challenges facing Australia's people and its places.Read moreRead less
Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
Epigenetic silencing in vertebrates: evolution and function from the bottom-up. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional genomics in Australia, with the research priority of Frontier Technologies for Building and Transforming Australian Industries and priority goals in Breakthrough Science and Frontier Technologies. This project focuses on important biological questions surrounding gene regulation and sex chromosome evolution. Inte ....Epigenetic silencing in vertebrates: evolution and function from the bottom-up. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional genomics in Australia, with the research priority of Frontier Technologies for Building and Transforming Australian Industries and priority goals in Breakthrough Science and Frontier Technologies. This project focuses on important biological questions surrounding gene regulation and sex chromosome evolution. International attention has already resulted in genome characterization of Australian icons (wallaby, Tasmanian devil and platypus), more research on these, and other Australian animals, will further highlight the importance of Australian fauna and impact positively on our scientific profile.Read moreRead less
Origin and Evolution of Mammalian Dosage Compensation. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional comparative genomics in Australia, with the research priority of 'Frontier Technologies for Building and Transforming Australian Industries' and priority goals in 'Breakthrough Science and Frontier Technologies'. This project addresses fundamental questions about the evolution of mammalian X-chromosome inactivation, of importance as a mo ....Origin and Evolution of Mammalian Dosage Compensation. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional comparative genomics in Australia, with the research priority of 'Frontier Technologies for Building and Transforming Australian Industries' and priority goals in 'Breakthrough Science and Frontier Technologies'. This project addresses fundamental questions about the evolution of mammalian X-chromosome inactivation, of importance as a model for epigenetic change, and sex chromosomes, which has engaged some of the greatest genetic minds over nearly a century. Therefore my results will attract wide international interest and impact positively on Australia's scientific profile, and further highlight the importance of Australian mammals.Read moreRead less
Increasing Visitor Frequency: approach to understanding and forecasting how cultural attraction visitors respond to various incentives to increase visitation rates. Museums have been steadily losing visitors over the past decade. While current research indicates that this may be attributed to greater leisure competition, little is understood about how people make choices to visit or not to visit cultural attractions. The aim of this project is to develop, demonstrate and test a Random Utility Th ....Increasing Visitor Frequency: approach to understanding and forecasting how cultural attraction visitors respond to various incentives to increase visitation rates. Museums have been steadily losing visitors over the past decade. While current research indicates that this may be attributed to greater leisure competition, little is understood about how people make choices to visit or not to visit cultural attractions. The aim of this project is to develop, demonstrate and test a Random Utility Theory (RUT)-based modelling approach allowing managers of cultural attractions to understand and predict the likely visitation consequences of potential initiatives. We wish to model visitor choices of museums versus other competing attractions to allow museums to identify specific strategic actions (or combinations) to achieve organisational goals.Read moreRead less
Urban Imaginaries/Cultural Landscapes: An Asia-Pacific Transnational and Cross-Cultural Research Collaboration. The aim of the program is to foster research collaboration between the ANU's Humanities Research Centre and Lingnan University's Cultural Research and Development Program by examining public culture, transnational culture, urban landscapes and urban cultural identities in the contemporary Asia-Pacific and Australian context. We will do this by extending ties with researchers from the ....Urban Imaginaries/Cultural Landscapes: An Asia-Pacific Transnational and Cross-Cultural Research Collaboration. The aim of the program is to foster research collaboration between the ANU's Humanities Research Centre and Lingnan University's Cultural Research and Development Program by examining public culture, transnational culture, urban landscapes and urban cultural identities in the contemporary Asia-Pacific and Australian context. We will do this by extending ties with researchers from the region including early career and students and by developing a comparative cross-cultural methodology capable of encompassing specific socio-historical patterns and processes of dynamically changing public cultural formations in contemporary urban centres in the Asia-Pacific, including Australia. Specific outcomes include a book, e-journal and a multi-media exhibition.
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Using high-resolution lasers to test quantum electrodynamics. High-precision laser-based measurements of atomic and molecular structure are benchmarks for our fundamental understanding of matter. This project will undertake state-of-the-art experiments on atomic helium, to test and challenge current theoretical predictions of fundamental quantum-electrodynamic properties for helium and for more complex atoms.