Dissecting The Pseudoexfoliation Syndrome With Complementary Genetic, Proteomic And Biophysical Strategies
Funder
National Health and Medical Research Council
Funding Amount
$490,352.00
Summary
Pseudoexfoliation syndrome (PEX) is an eye condition in which flaky material deposits in the eye, greatly increasing the risk of cataract and glaucoma which can lead to blindness. PEX is also associated with heart disease, strokes and aneurysms. Cataract surgery in PEX patients has a higher rate of complications. In this project we will determine the nature of PEX material and why it forms. This knowlege will facilitate better diagnosis and treatment of PEX preventing associated blindness.
ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial ....ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial concepts into statistical analysis and modelling, powerful visualisation of information, and the building spatial decision support systems, to provide an improved evidence base and better informed decision-making to address the significant challenges facing Australia's people and its places.Read moreRead less
Special Research Initiatives - Grant ID: SR0354538
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
Enabling Sciences Education (EnSE) Research Network. The Network aims to ensure the long-term ability of Australians to excel in scientific and technological innovation at all levels of community activity. This will be achieved by establishing significant and ambitious research agendas for improving the teaching and learning of Mathematics, Science and Technology in primary, secondary and tertiary education sectors. Of significance will be the productive synergies flowing from uniting, across ....Enabling Sciences Education (EnSE) Research Network. The Network aims to ensure the long-term ability of Australians to excel in scientific and technological innovation at all levels of community activity. This will be achieved by establishing significant and ambitious research agendas for improving the teaching and learning of Mathematics, Science and Technology in primary, secondary and tertiary education sectors. Of significance will be the productive synergies flowing from uniting, across the three disciplines, Australia's most outstanding, experienced and dedicated researchers with new and mid-career colleagues. Expected outcomes include a diverse but cohesive and collaborative research community that provides international leadership in helping students achieve their full potential. Read moreRead less
Museum of New and Old Art (MONA) and the social and cultural coordinates of urban regeneration through arts tourism. This project will analyse the extraordinary success of MONA (Museum of New and Old Art) as an art gallery and use this information to identify, stimulate and sustain innovative collaborations between MONA, the cities of Hobart and Glenorchy, and the state of Tasmania, aimed at maximising visitor numbers to the state from art related tourism.
Founders and survivors: Australian lifecourses in historical context. This project will create one of the world's outstanding longitudinal studies of human health and resilience. It will contribute to the historical understanding of European migration, settler colonialism, forced labour and human health under stress, long-run family formation and falling fertility, household economy, and the social determinants of health. It will contribute to debate both nationally and internationally on the lo ....Founders and survivors: Australian lifecourses in historical context. This project will create one of the world's outstanding longitudinal studies of human health and resilience. It will contribute to the historical understanding of European migration, settler colonialism, forced labour and human health under stress, long-run family formation and falling fertility, household economy, and the social determinants of health. It will contribute to debate both nationally and internationally on the long-run effects of social and biomedical interventions and of investment in human capital. It will tell the grassroots history of the Australian penal and colonial experiments and it will form a scholarly coalition with the great community of family historians. Read moreRead less
Defining the Status of Culturally and Linguistically Diverse Young People. This project aims to improve the social cohesion of Australian society and the living standards of a significant group of our young people. Around 25 per cent of all Australians aged 12 to 24 are from culturally and linguistically diverse (CALD) backgrounds. In collaboration with nine Australian organisations, the project aims to critically define the status of CALD youth; develop the first national status reporting frame ....Defining the Status of Culturally and Linguistically Diverse Young People. This project aims to improve the social cohesion of Australian society and the living standards of a significant group of our young people. Around 25 per cent of all Australians aged 12 to 24 are from culturally and linguistically diverse (CALD) backgrounds. In collaboration with nine Australian organisations, the project aims to critically define the status of CALD youth; develop the first national status reporting framework for the group that will generate new social, economic and cultural indicators; and build a knowledge hub to store and curate CALD youth data. Data and understanding from this project is intended to enable governments to meet the group’s specific needs and enhance their opportunities.Read moreRead less
A history of press photography in Australia. Press photography has long influenced how Australians have understood themselves and their world. In collaboration with the National Library of Australia and the Walkley Foundation, the project explores the evolving role of photographs in breaking news, and historical shifts in photographic technologies, media practices and ethics.
Return, reconcile, renew: understanding the history, effects and opportunities of repatriation and building an evidence base for the future. The repatriation of ancestral remains is an extraordinary Indigenous achievement and inter-cultural development of the past 40 years. This international project will provide critical new knowledge to understand repatriation, its history and effects and will provide scholarly and public outcomes that empower community-based research and practice.
Identification And Characterisation Of Novel Genes For Congenital Cataract
Funder
National Health and Medical Research Council
Funding Amount
$432,750.00
Summary
Cataracts are the leading cause of blindness worldwide. The term describes a clouding of the lens which may lead to visual impairment. Congenital cataracts (present at birth) are less common than age-related cataract but the lifelong impact on vision can be severe, with a third of patients remaining legally blind. Late complications such as aphakic glaucoma may be blinding. We have shown that congenital cataracts are often inherited and have performed a population-based study in South-Eastern Au ....Cataracts are the leading cause of blindness worldwide. The term describes a clouding of the lens which may lead to visual impairment. Congenital cataracts (present at birth) are less common than age-related cataract but the lifelong impact on vision can be severe, with a third of patients remaining legally blind. Late complications such as aphakic glaucoma may be blinding. We have shown that congenital cataracts are often inherited and have performed a population-based study in South-Eastern Australia over the past 5 years to determine the causative genes. A large number of families have been involved in the study and solid progress has been made in identifying mutations in cataract genes and understanding what effect these may have on the patient's prognosis. We have recently identified a new gene in a large Australian family with a syndrome of cataract, mental retardation and teeth problems. This syndrome, known as Nance-Horan syndrome was originally described in Australia 30 years ago and we have worked with the original family to find the exact gene responsible. We already know that this gene causes the same syndrome in other families and in this project we will examine whether it can cause cataract without the other features or mental retardation without cataract. We will perform a series of experiments to learn what this gene does and how it causes the disease. We have also selected 3 other very interesting families with congenital cataracts for further study as we either know already or strongly suspect that they will enable us to identify further new genes for cataract, and in one case mental retardation. Our work in other diseases indicates that understanding the genes in severe young onset cases can give valuable clues to the causes of age-related forms and may in the future enable new ways to prevent and treat the commonest cause of worldwide blindness.Read moreRead less
ARC Research Network for Early European Research. The Network offers a dynamic resource for enhancing Australian research into the culture and history of Europe between the fifth and nineteenth centuries. Through a programme of dedicated conferences and symposia, new digital resources, publications, and specialist postgraduate mentoring, Network management will mobilise existing strengths to build up national and international research partnerships in key emerging areas of scholarly enquiry. The ....ARC Research Network for Early European Research. The Network offers a dynamic resource for enhancing Australian research into the culture and history of Europe between the fifth and nineteenth centuries. Through a programme of dedicated conferences and symposia, new digital resources, publications, and specialist postgraduate mentoring, Network management will mobilise existing strengths to build up national and international research partnerships in key emerging areas of scholarly enquiry. The Network will coordinate large-scale cross-disciplinary investigations, strengthen links with cultural heritage institutions and organizations, and nurture the next generation of researchers. It will make innovative use of digital infrastructure to manage communication and to disseminate results.Read moreRead less