Attention deficit hyperactivity disorde(ADHD) is the most prevalent mental disorder of childhood affecting around 7.5% of Australian school age children. The disorder is strongly genetic and causes significant impairments in academic functioning, family and peer relations with sufferers at increased risk for drug abuse. Identification and characterisation of rare mutations will enhance our knowledge of the neurobiology and advance the search for next generation drug treatments for the disorder.
How Does Fra-1 Regulate The Invasive Properties Of Tumour Cells?
Funder
National Health and Medical Research Council
Funding Amount
$468,119.00
Summary
Most cancer deaths occur when tumours spread and destroy vital body functions. The invasion of tumour cells into surrounding tissue is a critical step during the spread of cancer. This project aims to unravel the molecular mechanisms that control the ability of tumour cells to invade into surrounding tissue and subsequently spread to other sites in the body. We expect to identify potential targets to better diagnose and treat the spread of cancer.
Regulation Of Actin Polymerization During Malaria Parasite Invasion Of The Human Erythrocyte
Funder
National Health and Medical Research Council
Funding Amount
$318,147.00
Summary
Malaria parasites depend on successful invasion of red blood cells for their survival. Invasion is powered by a molecular motor based on two key proteins: actin and myosin. Non-specific drugs that inhibit parasite actin block invasion, demonstrating how important its regulation is to parasite success. This project will study several newly identified malaria actin-regulators, aiming to identify new drug targets that will block malaria actin function, stop motility and as such prevent disease.
Dynamics and correlations of many-body systems. The proposed program will greatly enhance Australian science through linking innovative
theoretical techniques with the successful ongoing Australian experimental program in atom
lasers, atom chip interferometry and ultra-cold fermions. Pioneering theoretical methods in
quantum phase-space are internationally recognized, and will be extended into new areas relevant
to Australia. These have fundamental significance to fields ranging from nanotec ....Dynamics and correlations of many-body systems. The proposed program will greatly enhance Australian science through linking innovative
theoretical techniques with the successful ongoing Australian experimental program in atom
lasers, atom chip interferometry and ultra-cold fermions. Pioneering theoretical methods in
quantum phase-space are internationally recognized, and will be extended into new areas relevant
to Australia. These have fundamental significance to fields ranging from nanotechnology to
astrophysics, as well as providing a route to improved atomic clocks and other instruments.
Combining these theoretical and computational methods from the physical sciences with biology
and genetics will provide future cross-disciplinary benefits to Australian biomedical science.Read moreRead less
The importance of the fictional character in literary theory and cultural practice. This project is a theoretical research project which aims to make significant and innovative contributions to research excellence in literature and the history of ideas. This research focuses on the fictional character, one of the central categories of literary theory. The benefits flowing from it will primarily be an enhanced understanding of the workings and the history of a category that informs every domain o ....The importance of the fictional character in literary theory and cultural practice. This project is a theoretical research project which aims to make significant and innovative contributions to research excellence in literature and the history of ideas. This research focuses on the fictional character, one of the central categories of literary theory. The benefits flowing from it will primarily be an enhanced understanding of the workings and the history of a category that informs every domain of cultural practice.Read moreRead less
Fermionic superfluidity in lower dimensional quantum gases. This project seeks to carry out cutting edge research on fermionic superfluidity using ultracold quantum gases. Through collaboration with one of the world's leading groups we will investigate the emerging issue of superfluidity in two-dimensional environments. This research will forge strong links with the European community and raise Australia's international profile in this rapidly growing field. Outstanding opportunities for youn ....Fermionic superfluidity in lower dimensional quantum gases. This project seeks to carry out cutting edge research on fermionic superfluidity using ultracold quantum gases. Through collaboration with one of the world's leading groups we will investigate the emerging issue of superfluidity in two-dimensional environments. This research will forge strong links with the European community and raise Australia's international profile in this rapidly growing field. Outstanding opportunities for young Australian scientists will arise through this collaboration and our findings may have implications for future superconducting technologies, based on the remarkable properties of fermionic superfluids.Read moreRead less
Life is swirl in flatland: two dimensional turbulence in a superfluid. The project will create two-dimensional turbulence in a superfluid gas of atoms in order to observe the predicted, but counter-intuitive, growth of ordered structure out of chaotic motion. The observation of such behaviour would support its mechanism as the explanation for phenomena such as giant eddies in ocean currents and the Great Red Spot of Jupiter.
Generation and Application of Ultracold Molecules. This project will extend the techniques of laser trapping and cooling of neutral atoms to produce ensembles of ultracold molecules, specifically Rb2. The starting point will be a cold sample of atoms, followed by the photoassociative formation of ultracold molecules. The ultracold molecules will be collected in a far-detuned optical dipole trap, and subsequently probed using femtosecond time-resolved spectroscopy. This unique combination of femt ....Generation and Application of Ultracold Molecules. This project will extend the techniques of laser trapping and cooling of neutral atoms to produce ensembles of ultracold molecules, specifically Rb2. The starting point will be a cold sample of atoms, followed by the photoassociative formation of ultracold molecules. The ultracold molecules will be collected in a far-detuned optical dipole trap, and subsequently probed using femtosecond time-resolved spectroscopy. This unique combination of femtosecond spectroscopy with ultraslow molecules will extend the study of chemical processes to an entirely new temperature regime, leading to a new understanding of the quantum nature of chemical reactions.Read moreRead less
Mobile Indonesians: social differentiation and digital literacies in the twenty first century. This is the first dedicated study of the social implications of mobile telephony's recent and rapid popularisation throughout the country. This project will study metropolitan, urban and rural users to understand how mobile phones create the new and unexpected social networks which will shape tomorrow's Indonesians.
Affective Communities: Anti-Imperial Thought and the Politics of Friendship. This project is a study of five friendships between anti-imperial Europeans and South Asians at the turn of the nineteenth-century. Its aim is to offer a reading of anti-colonial politics as the product of numerous transnational collaborations, friendships and conversations between western and non-western dissidents. It will extend the theoretical paradigms of postcolonial studies by challenging orthodox understandings ....Affective Communities: Anti-Imperial Thought and the Politics of Friendship. This project is a study of five friendships between anti-imperial Europeans and South Asians at the turn of the nineteenth-century. Its aim is to offer a reading of anti-colonial politics as the product of numerous transnational collaborations, friendships and conversations between western and non-western dissidents. It will extend the theoretical paradigms of postcolonial studies by challenging orthodox understandings of the colonial encounter as a violent and antagonistic clash between western power and non-western dissidence. New information will also be brought to bear on the history of the Indo-European colonial encounter.Read moreRead less