Kingdom switching microbial pathogens: the bioinformatics of mutation in the genomes of viruses and bacteria affecting crops, livestock and people. Some organisms that cause infectious diseases have moved between plants and vertebrates, either recently or repeatedly over evolutionary time. Switching between plants and vertebrates strongly influences the way these microbes mutate and evolve. We will search the genomic sequence databases for information about how the choice of host influences muta ....Kingdom switching microbial pathogens: the bioinformatics of mutation in the genomes of viruses and bacteria affecting crops, livestock and people. Some organisms that cause infectious diseases have moved between plants and vertebrates, either recently or repeatedly over evolutionary time. Switching between plants and vertebrates strongly influences the way these microbes mutate and evolve. We will search the genomic sequence databases for information about how the choice of host influences mutations in viral and bacterial genomes and model the evolutionary processes involved. This project will advance our understanding of the fine structure of microbial genomes and the importance of selection pressures on genes. It will lead to better disease management strategies for humans, and for domestic crops and livestock.Read moreRead less
The cellular basis of sex-specific responses to virus infection. This project aims to explore how the sex of cells impacts virus infections in culture. To date, the sex of cells in culture has been overlooked as an important source of biological variability, but may be found to affect basic science through to anti-viral drug discovery. Using a model in which a virus can be adapted to grow better in cells of a single sex, this project expects to generate new knowledge about how sex differences im ....The cellular basis of sex-specific responses to virus infection. This project aims to explore how the sex of cells impacts virus infections in culture. To date, the sex of cells in culture has been overlooked as an important source of biological variability, but may be found to affect basic science through to anti-viral drug discovery. Using a model in which a virus can be adapted to grow better in cells of a single sex, this project expects to generate new knowledge about how sex differences impact virus-host interactions. This project expects to provide new insights into sex-based differences in how cells detect and respond to virus infection, and the extent to which the sex of cells impacts viruses in general.Read moreRead less
New targets for antiviral therapies. The ability of dangerous viruses to cause lethal disease depends on their capacity to evade the immune system of infected hosts. This project will uncover at the molecular level the strategies used by viruses to disable immune responses; this will identify new ways to treat incurable diseases, by disabling the virus' defences against the immune system.
Nucleolus targeting by negative strand RNA viruses. Negative strand viruses (NSVs) include diverse animal pathogens that represent significant threats to Australian livestock industries and access to export markets. The project aims to investigate the interface formed by NSVs with cellular nucleoli in order to determine roles in viral manipulation of cell biology during infection. This project hopes to address a major gap in knowledge in virology regarding the fundamental biology of NSVs, and is ....Nucleolus targeting by negative strand RNA viruses. Negative strand viruses (NSVs) include diverse animal pathogens that represent significant threats to Australian livestock industries and access to export markets. The project aims to investigate the interface formed by NSVs with cellular nucleoli in order to determine roles in viral manipulation of cell biology during infection. This project hopes to address a major gap in knowledge in virology regarding the fundamental biology of NSVs, and is expected to redefine our understanding of the virus-host interactions formed by these important pathogens. By determining the mechanisms of NSV-nucleolus interaction, the project plans to also provide important information for the development of new vaccines/therapeutics for livestock to combat NSVs that target nucleoli.Read moreRead less
Positronic Atoms - A Search for Positron Bound States. An experimental verification of positron bound states will solve a long standing problem in positron physics. A clear understanding of positron binding and the underlying mechanisms will open a new era in low-energy positron-atom/molecular physics, leading the way for breakthrough sciences. For instance, a positron bound state should enhance the annihilation rate between the positron and target valence electron. Positron annihilation, to pro ....Positronic Atoms - A Search for Positron Bound States. An experimental verification of positron bound states will solve a long standing problem in positron physics. A clear understanding of positron binding and the underlying mechanisms will open a new era in low-energy positron-atom/molecular physics, leading the way for breakthrough sciences. For instance, a positron bound state should enhance the annihilation rate between the positron and target valence electron. Positron annihilation, to produce two gamma rays, is a key process in both materials research (e.g. as already heavily employed in defect detection) and bio-medical treatments (e.g. the Positron Emission Tomography, or PET).Read moreRead less
A Microscope for Molecular Reactions. We are proposing to combine new, state-of-the-art detector technology and innovative experimental techniques in the development of A Microscope for Molecular Reactions. This device will enable precise and highly efficient studies on the structure of molecules and their interactions with the physical world. It will be applied to a broad range of problems in contemporary atomic and molecular physics, and will lead to new insights into the dynamics of such re ....A Microscope for Molecular Reactions. We are proposing to combine new, state-of-the-art detector technology and innovative experimental techniques in the development of A Microscope for Molecular Reactions. This device will enable precise and highly efficient studies on the structure of molecules and their interactions with the physical world. It will be applied to a broad range of problems in contemporary atomic and molecular physics, and will lead to new insights into the dynamics of such reactions and their role in our everyday lives.Read moreRead less
Benchmark Studies of Positron Interactions with Helium. Australia has been at the forefront of experimental studies of electron-driven processes and theoretical descriptions of positron interactions. A new experimental program to study experimental low energy positron atomic physics provides a perfect synergy of these two areas of expertise. The field is a relatively new and emerging one and is focused around a number of new experimental approaches, such as those being developed at the Austral ....Benchmark Studies of Positron Interactions with Helium. Australia has been at the forefront of experimental studies of electron-driven processes and theoretical descriptions of positron interactions. A new experimental program to study experimental low energy positron atomic physics provides a perfect synergy of these two areas of expertise. The field is a relatively new and emerging one and is focused around a number of new experimental approaches, such as those being developed at the Australian National University. This set of experiments, on positron interactions with helium, will provide new experimental evidence to further our understanding of fundamental quantum processes and place Australia at the forefront of the field.Read moreRead less
Multiple ionization of atoms and molecules in strong laser fields. Our research contributes to multidisciplinary efforts to unravel the
fundamental mechanisms that govern interaction of intense laser
radiation with matter. Understanding and accurate numerical modelling
of such preocesses have far-reaching implications for astrophysics,
plasma physics and controlled fusion, life and materials sciences. The
research project will further enhance our reputation in an area where
Australian the ....Multiple ionization of atoms and molecules in strong laser fields. Our research contributes to multidisciplinary efforts to unravel the
fundamental mechanisms that govern interaction of intense laser
radiation with matter. Understanding and accurate numerical modelling
of such preocesses have far-reaching implications for astrophysics,
plasma physics and controlled fusion, life and materials sciences. The
research project will further enhance our reputation in an area where
Australian theorists are preeminent, and the research training will
produce PhD graduates with a high-level ability in numerical modelling
using supercomputers. Such skills are essential in many defense,
information and nano-technology applications of national priority.
Read moreRead less
Two-electron atomic photoionization in superstrong electromagnetic field. Correlation, or entanglement, of electrons in matter governs many important phenomena in nature, such as chemical reactions, superconductivity and ferromagnetism. However, it is the many-electron processes in atoms which allow the study of electron correlations most clearly. In this project we will investigate such a process of two-electron atomic photoionization by an intense laser pulse. We will combine advanced theoret ....Two-electron atomic photoionization in superstrong electromagnetic field. Correlation, or entanglement, of electrons in matter governs many important phenomena in nature, such as chemical reactions, superconductivity and ferromagnetism. However, it is the many-electron processes in atoms which allow the study of electron correlations most clearly. In this project we will investigate such a process of two-electron atomic photoionization by an intense laser pulse. We will combine advanced theoretical and experimental tools with the aim of understanding how the electron correlation interplays with the
superstrong electromagnetic field. This will provide insight into fundamental processes of interaction of intense laser pulses with matter which are important in a wide range of applications.
Read moreRead less
Atomic Ionization on the Attosecond Time Scale. Electrons emit light, carry electric current, and bind atoms together to form molecules. Insight into their atomic-scale motion is the key to understanding the functioning of biological systems, developing efficient sources of x-ray light, and speeding up electronics. Capturing this electron motion requires attosecond (one quintillionth of a second) time resolution. Our research aims to understand and accurately model fundamental atomic processes ....Atomic Ionization on the Attosecond Time Scale. Electrons emit light, carry electric current, and bind atoms together to form molecules. Insight into their atomic-scale motion is the key to understanding the functioning of biological systems, developing efficient sources of x-ray light, and speeding up electronics. Capturing this electron motion requires attosecond (one quintillionth of a second) time resolution. Our research aims to understand and accurately model fundamental atomic processes taking place on the attosecond time scale. This research project will further enhance our reputation in an area where Australian theorists are preeminent, and the research training will produce PhD graduates with the skills essential in a multitude of nano-technology applications. Read moreRead less