Indian Ocean Climate Change: Ningaloo Reef, a litmus test for the survival of coral reefs. Coral reefs are at the frontline from the effects of rapidly rising levels of carbon dioxide that is causing both global warming and oceans to become more acid-like. Our research program will determine how the survival of one of the World’s most pristine and best preserved coral reefs, Ningaloo Reef, is linked to the response of Australia’s Indian Ocean to climate change. For the first time, we will simula ....Indian Ocean Climate Change: Ningaloo Reef, a litmus test for the survival of coral reefs. Coral reefs are at the frontline from the effects of rapidly rising levels of carbon dioxide that is causing both global warming and oceans to become more acid-like. Our research program will determine how the survival of one of the World’s most pristine and best preserved coral reefs, Ningaloo Reef, is linked to the response of Australia’s Indian Ocean to climate change. For the first time, we will simulate realistic ‘future’ conditions and see how actual coral reef systems respond. This will provide a ‘yardstick’ against which the best-case survival potential of the world’s coral reefs can be assessed, critical for underpinning the urgently needed action to reduce greenhouse gas emissions if we are to ensure the survival of coral reefs.Read moreRead less
AusDiab 3: Emerging Risk Factors For And Long-term Incidence Of Cardio-metabolic Diseases
Funder
National Health and Medical Research Council
Funding Amount
$2,616,397.00
Summary
This study will track 11,000 Australian adults over 12 years to determine how many develop diabetes, obesity, kidney and heart disease. The study will develop ways to best predict those who are going to develop these conditions before they have arisen, and will explore a range of novel risk factors to better understand these conditions.
Australian Laureate Fellowships - Grant ID: FL150100133
Funder
Australian Research Council
Funding Amount
$2,917,436.00
Summary
How the Earth works - toward building a new tectonic paradigm. How the Earth works - toward building a new tectonic paradigm: This fellowship project aims to build on the latest technological and conceptual advances to establish the patterns of Earth evolution, and use this information to examine a ground-breaking geodynamic hypothesis which links cyclic plate aggregation and dispersion to deep Earth processes. Half a century after the inception of plate tectonics theory, we are still unsure how ....How the Earth works - toward building a new tectonic paradigm. How the Earth works - toward building a new tectonic paradigm: This fellowship project aims to build on the latest technological and conceptual advances to establish the patterns of Earth evolution, and use this information to examine a ground-breaking geodynamic hypothesis which links cyclic plate aggregation and dispersion to deep Earth processes. Half a century after the inception of plate tectonics theory, we are still unsure how the Earth 'engine' works, particularly the forces that drive plate tectonics. The project involves extensive national and international collaboration to potentially create a paradigm shift in our understanding of global tectonics, and hopes to contribute to an understanding of the formation and distribution of Earth resources to provide a conceptual framework for their exploration.Read moreRead less
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
A National Population-based Study Of Rheumatic Heart Disease In Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$877,826.00
Summary
Whilst overall a rare disease, Indigenous peoples have disproportionately high rates of rheumatic heart disease (RHD). This study explores the prevalence and distribution of RHD in pregnancy in Australia and New Zealand. It details current management, diagnostic and referral process and risk factors. Key attributes of culturally safe models of care for RHD in pregnancy are explored, particularly as they relate to Indigenous women. Findings will inform policy, guidelines and education resources.
High Penetrance Deleterious Mutations In Blinding Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$1,345,055.00
Summary
This project aims to identify the genes most commonly mutated in individuals with advanced glaucoma. Identification of such genes will lead to improved understanding of glaucoma pathogenesis, a better ability to predict risk, and the identification of drug targets for novel therapies.
Translating Genetic Determinants Of Glaucoma Into Better Diagnosis And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$9,466,000.00
Summary
Glaucoma is the leading cause of irreversible blindness worldwide. By 2020, it will affect 80 million people, and in Australia over the next decade, the overall cost of glaucoma will reach $4.3 billion per annum. This Program will use genetic advances to personalise treatment. Blindness will be prevented in individuals at highest risk, new ways to treat patients will be developed, and better outcomes for patients will result from less treatment and monitoring of low risk cases.
The Australian Centre of Excellence in Twin Research will build on the Australian Twin Registry, which for 30 years has played an integral part in health & medical research. The new Centre aims to expand a state-of-the-art resource for conducting research, bring together leading national and international researchers from across disciplines, and build capacity in people, techniques, and expertise to continue to enable twin research to address major health and medical issues.
Improving Health Outcomes In The Tropical North: A Multidisciplinary Collaboration
Funder
National Health and Medical Research Council
Funding Amount
$5,997,916.00
Summary
Improving Health Outcomes in the Tropical North will strengthen partnerships with research institutions in the NT, Qld, WA, NSW, Vic and SA, by undertaking a research agenda that will help close the gap in Indigenous health disadvantage, protect the north from emerging infectious threats and engage regional neighbours. We will establish a northern Australian network that incorporates Indigenous engagement, mentoring and knowledge translation, and facilitates collaboration with southern partners.
Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.