The Burden And Risk Factors Of Depressive Disorders In Indigenous Australians: Implications For Early Detection And Prevention
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This Fellowship addresses the high rates of depression amongst Indigenous Australians. The proposed work will quantify the extent to which two major risk factors contribute to the burden of depression in this population and the burden avertable from interventions to modify these risk factors. Findings would inform resource allocation and health service delivery, and in doing so, present opportunities for improvements in the health of Indigenous Australians.
A Practice Change For Patients With Severe Chronic, Clinically Unexplained Gastrointestinal Symptoms: A Randomised, Controlled Intervention To Assess Efficacy And Cost-effectiveness
Funder
National Health and Medical Research Council
Funding Amount
$1,276,080.00
Summary
Unexplained chronic gastrointestinal symptoms are extremely common and costly to the health system. Currently patients are managed in the hospital setting with the 'typical' face-to-face office-based model which sees the clinician spending valuable time gathering information and often treatments (e.g. allied health) delivered in a non-standard way. This project will evaluate the effectiveness of a new standard best-practice clinical model with a structured technology enabled management approach.
Resilience of eucalypts to future droughts. This project aims to examine how resilient Eucalyptus species are to future droughts by combining data synthesis, manipulative experiments and modelling. Climate change is expected to increase the frequency, magnitude and duration of future droughts, with major environmental and socio-economic consequences for Australia. Current predictive capacity is extremely limited: experiments are limited in scale and cannot capture important global change interac ....Resilience of eucalypts to future droughts. This project aims to examine how resilient Eucalyptus species are to future droughts by combining data synthesis, manipulative experiments and modelling. Climate change is expected to increase the frequency, magnitude and duration of future droughts, with major environmental and socio-economic consequences for Australia. Current predictive capacity is extremely limited: experiments are limited in scale and cannot capture important global change interactions, whilst models do not represent the functional characteristics and adaptions of eucalypts. This project will develop a strong evidence- and process-based understanding to quantify the functional behaviour of drought-adapted Eucalyptus species and leverage this insight to make future model projections.Read moreRead less
A reduced capacity to recover balance following an imbalance episode contributes to the high incidence of falls in older adults. The goal of the present study is to determine how age-related differences in lower extremity neuromuscular and biomechanical properties are related to balance recovery capacity and falls incidence. A detailed understanding of this relationship is necessary for the development of efficacious exercise-based interventions for the prevention of falls.
The effect of native invasions on Australian fisheries species. This project aims to forecast climate-related changes in the diversity, distribution and abundance of fisheries species. In a changing world where many people depend on oceans for food and livelihood, predicting the future distribution of fisheries species is a challenge. Native invasions and ocean warming are stressing inshore fisheries species, but rigorous empirical data and models that can reliably forecast these effects are lac ....The effect of native invasions on Australian fisheries species. This project aims to forecast climate-related changes in the diversity, distribution and abundance of fisheries species. In a changing world where many people depend on oceans for food and livelihood, predicting the future distribution of fisheries species is a challenge. Native invasions and ocean warming are stressing inshore fisheries species, but rigorous empirical data and models that can reliably forecast these effects are lacking. This project intends to reveal the drivers of successful native invasions, evaluate their effect on fish diversity and productivity, and develop holistic models that forecast their effects on inshore fisheries species’ near-future distribution and stocks.Read moreRead less
Coupling tropical cyclone and climate physics with ocean waves. It is argued that without accounting for the wave effects directly, the physics of large-scale air-sea interactions is inaccurate and incomplete. The project will introduce explicit coupling of large-scale atmospheric and oceanic phenomena with the physics of surface waves which should lead to improved predictions of tropical cyclones and climate.
Indian Ocean Climate Change: Ningaloo Reef, a litmus test for the survival of coral reefs. Coral reefs are at the frontline from the effects of rapidly rising levels of carbon dioxide that is causing both global warming and oceans to become more acid-like. Our research program will determine how the survival of one of the World’s most pristine and best preserved coral reefs, Ningaloo Reef, is linked to the response of Australia’s Indian Ocean to climate change. For the first time, we will simula ....Indian Ocean Climate Change: Ningaloo Reef, a litmus test for the survival of coral reefs. Coral reefs are at the frontline from the effects of rapidly rising levels of carbon dioxide that is causing both global warming and oceans to become more acid-like. Our research program will determine how the survival of one of the World’s most pristine and best preserved coral reefs, Ningaloo Reef, is linked to the response of Australia’s Indian Ocean to climate change. For the first time, we will simulate realistic ‘future’ conditions and see how actual coral reef systems respond. This will provide a ‘yardstick’ against which the best-case survival potential of the world’s coral reefs can be assessed, critical for underpinning the urgently needed action to reduce greenhouse gas emissions if we are to ensure the survival of coral reefs.Read moreRead less
Population-level Epidemiological Trends In Hepatocellular Carcinoma In Queensland 1996 - 2010.
Funder
National Health and Medical Research Council
Funding Amount
$251,695.00
Summary
Incidence and mortality of hepatocellular carcinoma (HCC, the most common form of liver cancer) is increasing in Australia, driven by viral hepatitis infections. Disease burden is not defined in Queensland, particularly for Indigenous, migrant and regional and remote communities. Such factors may influence risk of viral hepatitis, access to treatment, and incidence and survival of HCC. Defining disease burdens will enable clinical programs targeted at groups most at risk in order to impact HCC t ....Incidence and mortality of hepatocellular carcinoma (HCC, the most common form of liver cancer) is increasing in Australia, driven by viral hepatitis infections. Disease burden is not defined in Queensland, particularly for Indigenous, migrant and regional and remote communities. Such factors may influence risk of viral hepatitis, access to treatment, and incidence and survival of HCC. Defining disease burdens will enable clinical programs targeted at groups most at risk in order to impact HCC trends.Read moreRead less
Molecular Regulation Of Metabolism And Body Composition By Ski Via Crosstalk With Nuclear Hormone Receptor Signalling.
Funder
National Health and Medical Research Council
Funding Amount
$558,441.00
Summary
Obesity is a common and burdensome health problem in the community which leads to diabetes and heart disease. A number of factors, including hormones play important roles in determing risk of obesity. This study proposes to investigate whether the Ski gene which is a regulatory factor for many hormones affects metabolism in transgenic mouse models of altered Ski function. The proposed studies may identify Ski as a target for therapy for obesity and improvement in sketal muscle metabolism.