Precision Epigenetics: Targeting The Epigenome To Treat Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,940,576.00
Summary
Epigenetic marks are changes made to the DNA that allow genes to be switched off in some cells and switched on in others. These marks are critical to normal development and often go wrong in disease. We aim to find genes that add epigenetic marks to the DNA and understand how they co-operate at the molecular level to switch genes off. Our focus is on one such gene, SMCHD1. We are developing new drugs against SMCHD1 to treat incurable neurodevelopmental disorder PWS and muscular dystrophy FSHD.
Discovery Early Career Researcher Award - Grant ID: DE190100113
Funder
Australian Research Council
Funding Amount
$420,437.00
Summary
Interactions between volumetric units in modular buildings. This project aims to develop an in-depth understanding of the interactions between volumetric units in modular buildings to develop integration strategies for the interconnection of modules. The uptake of modular construction has been hindered by the technical complexities of the design process for manufacture and assembly, in particular the flexible connection of services. By addressing significant gaps in the guidance on the design of ....Interactions between volumetric units in modular buildings. This project aims to develop an in-depth understanding of the interactions between volumetric units in modular buildings to develop integration strategies for the interconnection of modules. The uptake of modular construction has been hindered by the technical complexities of the design process for manufacture and assembly, in particular the flexible connection of services. By addressing significant gaps in the guidance on the design of modular interconnections and their integration strategies, this project expects to enhance the industry’s capacity to adopt safe, economical and standardised designs of modular systems. This project should significantly reduce the risk in decision making in modular construction, and transformation to advanced building manufacturing technologies in Australia and beyond.Read moreRead less
Early African woodworking and tool use at the transition to modern humans. Our archaeological excavations and preliminary dating of Amanzi Springs (South Africa) to between 515,000 and 163,000 years ago shows that the site covers a critical time period that led to the origins of our species, Homo sapiens. Amanzi documents, in never before seen resolution, the technological leaps that our ancestors made during this transition. At ~400,000 years ago this includes the oldest evidence for woodworkin ....Early African woodworking and tool use at the transition to modern humans. Our archaeological excavations and preliminary dating of Amanzi Springs (South Africa) to between 515,000 and 163,000 years ago shows that the site covers a critical time period that led to the origins of our species, Homo sapiens. Amanzi documents, in never before seen resolution, the technological leaps that our ancestors made during this transition. At ~400,000 years ago this includes the oldest evidence for woodworking and tool use and >163,000 years ago the oldest heat treatment of rock to make stone tools. The organic preservation at the site means that we can reconstruct changing environment, linked to sea level changes and spring activity, for this period in the evolution of our ancestors at a level of detail not previously possibleRead moreRead less
Novel Approaches To Nanomedicines For Future Therapies
Funder
National Health and Medical Research Council
Funding Amount
$2,414,215.00
Summary
Nanomedicines have the potential to transform healthcare by targeting significant health issues such as Alzheimer’s, diabetes and Parkinson’s diseases that have mainly eluded successful therapeutic solutions. In addition, nanotechnology has the potential to significantly improve the treatment of chronic pain by repurposing analgesic medications for improved effectiveness without significant side effects. I will target these two areas of research during the next five years.
Understanding the survival of forests under drought . Droughts are predicted to become more extreme in the near future, with potentially devastating impacts on Australian forest ecosystems. This project aims to address key knowledge gaps in our understanding of how plants tolerate extreme drought stress and utilise this new knowledge to improve vegetation models suitable for assessing ecosystem vulnerability. We will use innovative experimental methodology to determine the processes by which wat ....Understanding the survival of forests under drought . Droughts are predicted to become more extreme in the near future, with potentially devastating impacts on Australian forest ecosystems. This project aims to address key knowledge gaps in our understanding of how plants tolerate extreme drought stress and utilise this new knowledge to improve vegetation models suitable for assessing ecosystem vulnerability. We will use innovative experimental methodology to determine the processes by which water transport breaks down in roots, stems and leaves and the mechanisms governing recovery from severe drought stress. The project will provide a deeper understanding of drought tolerance in trees, improved forecasting of risks to native vegetation, and enhanced management of native forest resources. Read moreRead less
Building Australia's next-generation ocean-sea ice model. Ocean and sea ice models are used for predicting future ocean and climate states, and for climate process research. This project aims to bring the next generation of ocean-sea ice models to Australia and configure the models for our local priorities. The ultimate goal is to create a new coupled ocean-sea ice model for Australia that includes surface waves and biogeochemistry. The model will be optimised and evaluated on Australian facilit ....Building Australia's next-generation ocean-sea ice model. Ocean and sea ice models are used for predicting future ocean and climate states, and for climate process research. This project aims to bring the next generation of ocean-sea ice models to Australia and configure the models for our local priorities. The ultimate goal is to create a new coupled ocean-sea ice model for Australia that includes surface waves and biogeochemistry. The model will be optimised and evaluated on Australian facilities, and released for community use. These developments underpin future ocean state forecasts, sea ice forecasts, wave forecasts, decadal climate prediction and climate process studies. The project will benefit search and rescue, Defence and shipping operations, and will enhance future climate projections.Read moreRead less
Safeguarding coral reef fisheries for future food security. This Fellowship aims to address the vulnerability of coral reef fisheries in Australia and the Indo-Pacific by identifying fishery targets that benefit human nutrition and will persist despite declining coral habitats and rising water temperature. This project will advance knowledge on coral and fish responses to increasingly frequent marine heatwaves, using novel methodologies rooted in ecological modelling, experimental marine biology ....Safeguarding coral reef fisheries for future food security. This Fellowship aims to address the vulnerability of coral reef fisheries in Australia and the Indo-Pacific by identifying fishery targets that benefit human nutrition and will persist despite declining coral habitats and rising water temperature. This project will advance knowledge on coral and fish responses to increasingly frequent marine heatwaves, using novel methodologies rooted in ecological modelling, experimental marine biology and climate forecasting. Expected outcomes include (i) a comprehensive toolbox for improved management of coral reefs and associated fisheries in Australia and beyond, and (ii) an integrated socio-ecological model for predicting coral reef fishery responses under environmental change.Read moreRead less
Early desert settlement of Arabia following out-of-Africa human dispersals. This project aims to improve our understanding of the nature, timing and climatic context of early human expansion into SW Asia, from a new extensive archaeological complex with associated palaeoenvironmental sequences on the Arabian Peninsula – a strategic out-of-Africa migratory corridor. It will combine innovative approaches in archaeology, geochronology and palaeoenvironmental research to evaluate the environmental a ....Early desert settlement of Arabia following out-of-Africa human dispersals. This project aims to improve our understanding of the nature, timing and climatic context of early human expansion into SW Asia, from a new extensive archaeological complex with associated palaeoenvironmental sequences on the Arabian Peninsula – a strategic out-of-Africa migratory corridor. It will combine innovative approaches in archaeology, geochronology and palaeoenvironmental research to evaluate the environmental and cultural adaptability of early desert settlement, providing critical new insights into globally significant human dispersal debates spanning multiple continents, including Australia. The aim is a fundamental new perspective on long-term human occupation dynamics of deserts and new understanding of regional dispersals.Read moreRead less
ARC Centre of Excellence for the Weather of the 21st Century. ARC Centre of Excellence for the Weather of the 21st Century. This Centre aims to determine how Australia’s weather is being reshaped by climate change. Through a fusion of innovative analyses of observations and fundamental science advances, alongside the development of ultra-high resolution climate models, the Centre looks to address climate science’s grand challenge in anticipating the likely weather patterns of a warmer world. The ....ARC Centre of Excellence for the Weather of the 21st Century. ARC Centre of Excellence for the Weather of the 21st Century. This Centre aims to determine how Australia’s weather is being reshaped by climate change. Through a fusion of innovative analyses of observations and fundamental science advances, alongside the development of ultra-high resolution climate models, the Centre looks to address climate science’s grand challenge in anticipating the likely weather patterns of a warmer world. The Centre strives to transform climate research by focussing on what matters most to making critical adaptation and mitigation decisions – weather change. The Centre aspires to provide Australia with the knowledge, technology, and human capital for robust evidence-based decision-making in response to future weather changes in our region and to harness weather as a resource.Read moreRead less
Resilience of eucalypts to future droughts. This project aims to examine how resilient Eucalyptus species are to future droughts by combining data synthesis, manipulative experiments and modelling. Climate change is expected to increase the frequency, magnitude and duration of future droughts, with major environmental and socio-economic consequences for Australia. Current predictive capacity is extremely limited: experiments are limited in scale and cannot capture important global change interac ....Resilience of eucalypts to future droughts. This project aims to examine how resilient Eucalyptus species are to future droughts by combining data synthesis, manipulative experiments and modelling. Climate change is expected to increase the frequency, magnitude and duration of future droughts, with major environmental and socio-economic consequences for Australia. Current predictive capacity is extremely limited: experiments are limited in scale and cannot capture important global change interactions, whilst models do not represent the functional characteristics and adaptions of eucalypts. This project will develop a strong evidence- and process-based understanding to quantify the functional behaviour of drought-adapted Eucalyptus species and leverage this insight to make future model projections.Read moreRead less