Wideband Silicon-Based Radio-Frequency Front-End Module for 5G New Radio . The project aims to advance knowledge in radio-frequency integrated circuit design in low-cost silicon technologies, particularly power amplifiers design with enhanced energy efficiency at output power back-off levels. The intended outcome of this project will be a wideband RF front-end module with beam steering capability that can cover the 24-50 GHz spectrum band. This will ultimately enable the creation of a low-cost a ....Wideband Silicon-Based Radio-Frequency Front-End Module for 5G New Radio . The project aims to advance knowledge in radio-frequency integrated circuit design in low-cost silicon technologies, particularly power amplifiers design with enhanced energy efficiency at output power back-off levels. The intended outcome of this project will be a wideband RF front-end module with beam steering capability that can cover the 24-50 GHz spectrum band. This will ultimately enable the creation of a low-cost and energy-efficient 5G millimetre-wave network that could potentially trigger the development of ultra-reliable low latency communications, which is critical for emerging intelligent transportation systems and will maintain Australia’s leadership position in the development of break-through wireless technology.Read moreRead less
Low-Cost Wireless Transmitter with Compact Package for Industrial Sensing . This project aims to provide a solid foundation for silicon-based transmitter design with beam-steering capability operating beyond 100 GHz. The project expects to advance knowledge in low-cost radio-frequency integrated circuit design with miniaturised packaging technology for use in industrial sensing. Expected outcomes of this project include a prototype consisting of a miniaturised 140-GHz phased-array transmitter wi ....Low-Cost Wireless Transmitter with Compact Package for Industrial Sensing . This project aims to provide a solid foundation for silicon-based transmitter design with beam-steering capability operating beyond 100 GHz. The project expects to advance knowledge in low-cost radio-frequency integrated circuit design with miniaturised packaging technology for use in industrial sensing. Expected outcomes of this project include a prototype consisting of a miniaturised 140-GHz phased-array transmitter with packaged antenna arrays, along with a developed selection guideline to choose the "best" silicon-based technology node for cost-effective design. This should provide benefits for organisations working on wireless sensing technologies and lead to new ways of using these technologies for a variety of emerging applications.Read moreRead less
Microfluidic platforms for studying foam cell formation in vessels . This project aims to create technology platforms, utilising microfluidics and machine learning, to study the fundamental biological processes underlying the accumulation of immune cells underneath the vessel wall, which is known as foam cell formation. This project expects to deliver technologies, which facilitate mimicking and analysis of the complex dynamics of the human vessels in a more accurate, time- and cost-effective ma ....Microfluidic platforms for studying foam cell formation in vessels . This project aims to create technology platforms, utilising microfluidics and machine learning, to study the fundamental biological processes underlying the accumulation of immune cells underneath the vessel wall, which is known as foam cell formation. This project expects to deliver technologies, which facilitate mimicking and analysis of the complex dynamics of the human vessels in a more accurate, time- and cost-effective manner. The expected outcome will be cutting-edge tools and techniques to better understand the fundamental biological mechanisms driving foam cell formation. This should facilitate the development of future cardiovascular drug discovery technologies, which would benefit the biotechnology and pharmaceutical industries.Read moreRead less
Precise, Cytosolic Dendrimer Delivery Systems. This project aims to use precisely targeted dendrimer technology to improve the delivery of poorly permeable molecules to their subcellular sites of action. Our cutting edge approach combines innovative phage screening techniques and advanced dendrimer synthesis. The outcomes of this proposal will be: 1) a targeting system that is manufacturable at scale and reasonable cost, 2) a dendrimer delivery system that is rapidly internalised into specifc ta ....Precise, Cytosolic Dendrimer Delivery Systems. This project aims to use precisely targeted dendrimer technology to improve the delivery of poorly permeable molecules to their subcellular sites of action. Our cutting edge approach combines innovative phage screening techniques and advanced dendrimer synthesis. The outcomes of this proposal will be: 1) a targeting system that is manufacturable at scale and reasonable cost, 2) a dendrimer delivery system that is rapidly internalised into specifc target cells and 3) bio-responsive dendrimers that promote delivery of their cargo into the cytosol. This work will strengthen a highly successful collaboration between the Australian biotech company Starpharma and Monash University, to design the next generation of nanomaterials delivery systems.Read moreRead less
Next generation closed-loop brain-machine interfaces . Our partners Carbon Cybernetics have developed high-density neural recording and stimulation arrays that employ fine carbon fibres as the electrode material. The aim of the project is to exploit the properties of these materials to develop miniature implantable devices that are able to achieve long-term, closed-loop, high-resolution recording and stimulation within the brain. We aim to demonstrate an advanced algorithm for control of neural ....Next generation closed-loop brain-machine interfaces . Our partners Carbon Cybernetics have developed high-density neural recording and stimulation arrays that employ fine carbon fibres as the electrode material. The aim of the project is to exploit the properties of these materials to develop miniature implantable devices that are able to achieve long-term, closed-loop, high-resolution recording and stimulation within the brain. We aim to demonstrate an advanced algorithm for control of neural function. Devices that interface directly with the brain are increasingly important in neuroscience to understand how the brain processes information and creates memories and self awareness and are critically important to the development of technologies that interface electronics with the human body. Read moreRead less
Gut Absorption of Constrained Peptides for Local and Systemic Targeting. Aims: This project aims to investigate how peptides are absorbed across the intestinal wall and distributed to organs and fluids in a rodent model by combining bio-analysis and pharmacokinetics with high-resolution microscopy and imaging.
Significance: This project expects to generate the most comprehensive survey to date of the pathways and mechanisms of peptide absorption, biodistribution and immune cell targeting, by ....Gut Absorption of Constrained Peptides for Local and Systemic Targeting. Aims: This project aims to investigate how peptides are absorbed across the intestinal wall and distributed to organs and fluids in a rodent model by combining bio-analysis and pharmacokinetics with high-resolution microscopy and imaging.
Significance: This project expects to generate the most comprehensive survey to date of the pathways and mechanisms of peptide absorption, biodistribution and immune cell targeting, by implementing innovative approaches.
Expected Outcomes: Expected outcomes include significant new knowledge and a new multi-disciplinary platform for measuring peptide absorption.
Benefits: This should provide significant benefits by informing the future design of peptides for supplements, therapeutics and carriers. Read moreRead less
Damage Detection and Quantification using Infrastructure Digital Twins. Structural health monitoring is vital for infrastructure assets management as early detection of structural conditions is key to both safety and ongoing maintenance. This project combines computer vision, vibration tests, finite element modelling and deep learning technologies to develop an efficient structural health monitoring system. Digital twins created from images taken by cameras or UAVs will be correlated through dee ....Damage Detection and Quantification using Infrastructure Digital Twins. Structural health monitoring is vital for infrastructure assets management as early detection of structural conditions is key to both safety and ongoing maintenance. This project combines computer vision, vibration tests, finite element modelling and deep learning technologies to develop an efficient structural health monitoring system. Digital twins created from images taken by cameras or UAVs will be correlated through deep learning with structural conditions and load-carrying capacities obtained from vibration tests and finite element model analysis for efficient structural damage detection and quantification. The project will lead to effective structural health monitoring and enhance structural safety and reduce maintenance costs. Read moreRead less
Dating the aboriginal rock art sequence of the Kimberley in north west Australia. This project aims to develop a robust time scale for the known aboriginal rock art sequence in the Kimberley, Western Australia (WA). The project will use new knowledge of complex processes on sandstone surfaces across the north Kimberley, and an innovative combination of four scientific dating methods developed through our earlier work. The project expects to provide a well-dated sequence for Kimberley rock art ba ....Dating the aboriginal rock art sequence of the Kimberley in north west Australia. This project aims to develop a robust time scale for the known aboriginal rock art sequence in the Kimberley, Western Australia (WA). The project will use new knowledge of complex processes on sandstone surfaces across the north Kimberley, and an innovative combination of four scientific dating methods developed through our earlier work. The project expects to provide a well-dated sequence for Kimberley rock art based on replication of results, confirmation across different methods, and a large interdisciplinary data set. The project will allow rigorous analysis of the relationship between dating results and rock art styles that has not previously been possible, and give new insights into Australia’s deep indigenous heritage. This will have a significant impact for future efforts in rock art conservation, and lay a foundation for cultural tourism, with important benefits for the local economy and health of regional indigenous communities.Read moreRead less
Advanced protective coatings for thermal energy management devices. This project aims to develop new nanomaterial coatings and advanced plasma coating technology to address the global issue of e-waste caused by short lifespan thermal energy management devices (TEMDs) used in energy (solar, wind, oil), transport (aerospace, automotive, marine) and industrial (manufacturing, mining) sectors. The project expects to overcome issues of erosion and corrosion of TEMDs and toxic coating methods by devel ....Advanced protective coatings for thermal energy management devices. This project aims to develop new nanomaterial coatings and advanced plasma coating technology to address the global issue of e-waste caused by short lifespan thermal energy management devices (TEMDs) used in energy (solar, wind, oil), transport (aerospace, automotive, marine) and industrial (manufacturing, mining) sectors. The project expects to overcome issues of erosion and corrosion of TEMDs and toxic coating methods by developing new nanomaterial coatings and innovative plasma coating technology. This should provide significant benefits such as improved sustainability of TEMDs with improved corrosion resistance and durability, as well as new manufacturing products and processes that have far reaching economic benefits for Australia.Read moreRead less
Next generation smart lighting to improve sleep and alertness. Light has a powerful influence on our sleep and alertness. The manipulation of the amount of blue in a light source and the visual brightness of a light source are key factors, but there has been no systematic study that can guide manufacturers in the design of the ideal light source for promoting either sleep or alertness. This study will systematically examine the impact of the amount of blue light in a light source and the visual ....Next generation smart lighting to improve sleep and alertness. Light has a powerful influence on our sleep and alertness. The manipulation of the amount of blue in a light source and the visual brightness of a light source are key factors, but there has been no systematic study that can guide manufacturers in the design of the ideal light source for promoting either sleep or alertness. This study will systematically examine the impact of the amount of blue light in a light source and the visual brightness, creating a wide range of combinations that can be used to model the optimal light specifications for sleep and alertness, while maintaining visual acuity and colour discrimination. This will be the evidence base needed by the lighting industry to create the next generation of smart lighting.Read moreRead less