Nanoengineered Polymeric Materials for Environmental and Biological Applications. The development of advanced materials with nanoengineered properties promises to revolutionise future industries, including the energy and healthcare sectors. This research program will involve the design, synthesis and assembly of tailored polymers to prepare next-generation, engineered materials. The research will deliver advanced polymeric membranes, tissue engineering scaffolds and vaccine delivery systems. The ....Nanoengineered Polymeric Materials for Environmental and Biological Applications. The development of advanced materials with nanoengineered properties promises to revolutionise future industries, including the energy and healthcare sectors. This research program will involve the design, synthesis and assembly of tailored polymers to prepare next-generation, engineered materials. The research will deliver advanced polymeric membranes, tissue engineering scaffolds and vaccine delivery systems. These materials are expected to provide benefits for Australian citizens in the energy and health sectors and contribute to the development of a robust Australian nanotechnology industry. The projects will also provide opportunities for the development of outstanding young scientists and will foster multidisciplinary collaborations.Read moreRead less
Nanoimaging the cellular architecture of the malaria parasite, Plasmodium falciparum. The immediate benefit of this work will be in the understanding and treatment of malaria - a disease that kills approximately 1 million children annually. The ability to image the three-dimensional structure of cells at high resolution will allow us to ask fundamental questions about the cellular architecture of the malaria parasite and to design novel antimalarial strategies. By developing new methods for cor ....Nanoimaging the cellular architecture of the malaria parasite, Plasmodium falciparum. The immediate benefit of this work will be in the understanding and treatment of malaria - a disease that kills approximately 1 million children annually. The ability to image the three-dimensional structure of cells at high resolution will allow us to ask fundamental questions about the cellular architecture of the malaria parasite and to design novel antimalarial strategies. By developing new methods for correlating structure and elemental location, the work in this proposal will offer a new paradigm for the study of cellular function and disease. This represents an important advance in the suite of investigative tools available to the biotechology sector and will see a corresponding improvement in our understanding of a wide range of disease states.Read moreRead less
Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technologica ....Engineering Pore Forming Proteins as machines for the delivery of proteins and nanoparticles into cells. This cross disciplinary project will revolutionise our ability to build pore forming nano-machines that specifically deliver complex macromolecules to the cell cytoplasm. The ability to efficiently deliver molecules such as antibodies and nanoparticles to the correct cell population will have enormous therapeutic application. Further, such delivery devices will have revolutionary technological potential as commercially relevant research tools.Read moreRead less
Australia Surveys the Galaxies: The Central Role of Environment. The success of Australia's premier astronomical facilities is critical to the development of Australian astronomy in the 21st century. Understanding how galaxies grow and evolve (including our Milky Way) is one of the principal goals of these facilities. This program aims to understand galaxy evolution, by exploring the connection between galaxies and their environments. The Super Science Fellows will gain new insights into the lon ....Australia Surveys the Galaxies: The Central Role of Environment. The success of Australia's premier astronomical facilities is critical to the development of Australian astronomy in the 21st century. Understanding how galaxies grow and evolve (including our Milky Way) is one of the principal goals of these facilities. This program aims to understand galaxy evolution, by exploring the connection between galaxies and their environments. The Super Science Fellows will gain new insights into the longstanding problem of galaxy evolution, and build upon Australia's investment in 21st century astrophysics.Read moreRead less
Mass Assembly of Galaxies In the Cosmos: the roles of stars, gas, and metals. Swinburne's Centre for Astrophysics and Supercomputing is uniquely placed to tackle the outstanding 'super questions' of modern astronomy. We will utilise Australia's investment in current and future telescopes to unlock the process of galaxy assembly across cosmic time. New computing and instrumentation technologies will be developed. A further benefit is the training of young scientists to the highest level. The outc ....Mass Assembly of Galaxies In the Cosmos: the roles of stars, gas, and metals. Swinburne's Centre for Astrophysics and Supercomputing is uniquely placed to tackle the outstanding 'super questions' of modern astronomy. We will utilise Australia's investment in current and future telescopes to unlock the process of galaxy assembly across cosmic time. New computing and instrumentation technologies will be developed. A further benefit is the training of young scientists to the highest level. The outcomes of this research will further enhance Australia's international profile in astronomy.Read moreRead less
Peering through the Dark Ages with the Murchison Widefield Array. There is one large gap in our understanding of the early evolution of the universe, namely, when did the first sources of light appear? Resolution of this puzzle requires new observational and technical strategies, both in terms of telescopes and the analysis of observations. The Murchison Widefield Array, a major new radio telescope in Western Australia, is an international initiative under construction to tackle the problem. Thi ....Peering through the Dark Ages with the Murchison Widefield Array. There is one large gap in our understanding of the early evolution of the universe, namely, when did the first sources of light appear? Resolution of this puzzle requires new observational and technical strategies, both in terms of telescopes and the analysis of observations. The Murchison Widefield Array, a major new radio telescope in Western Australia, is an international initiative under construction to tackle the problem. This program will provide a significant Australian contribution at the forefront of modern cosmology.Read moreRead less
Design and Fabrication of Molecular Machines: the Nanomachines of the Future. Nanotechnology that incorporates the use of nanomachines and molecular machines is an exciting new area of translational research, with broad potential in biomedical technology and industrial applications. We are developing new molecular machines and optimising their assembly. Recent innovation in the world of nanotechnology concerns the design and manufacture of synthetic and hybrid machines, based on existing biologi ....Design and Fabrication of Molecular Machines: the Nanomachines of the Future. Nanotechnology that incorporates the use of nanomachines and molecular machines is an exciting new area of translational research, with broad potential in biomedical technology and industrial applications. We are developing new molecular machines and optimising their assembly. Recent innovation in the world of nanotechnology concerns the design and manufacture of synthetic and hybrid machines, based on existing biological molecular machines but incorporating synthetic parts. Australia has an opportunity to be at the forefront of these new developments in nanotechnology, with a new generation of Australian scientists being trained across the foundation disciplines of chemistry, physics and molecular biology.Read moreRead less
Space Science and Astronomy: Dissecting the Galaxy with High Resolution Multi-Object Echelle Spectrograph (HERMES) II: Decisive Observations. Australia has long been a world leader in wide-field astronomical surveys, and the new High Resolution Multi-Object Echelle Spectrograph (HERMES) being built for the Anglo-Australian Telescope (AAT) will enhance that leadership position. Through a combination of Australian technological and scientific advances, the surveys we conduct with HERMES will allow ....Space Science and Astronomy: Dissecting the Galaxy with High Resolution Multi-Object Echelle Spectrograph (HERMES) II: Decisive Observations. Australia has long been a world leader in wide-field astronomical surveys, and the new High Resolution Multi-Object Echelle Spectrograph (HERMES) being built for the Anglo-Australian Telescope (AAT) will enhance that leadership position. Through a combination of Australian technological and scientific advances, the surveys we conduct with HERMES will allow us to study galaxy formation and stellar astrophysics in unprecedented detail. There are powerful synergies between HERMES and Skymapper, another Australian astronomical survey, as well as with Gaia, the billion-dollar European space mission for studying the Galaxy; HERMES will thus promote both national and international research collaboration. In this proposal we lay the observational groundwork for maximising the scientific return from HERMES.Read moreRead less
A Changing Climate on the Great Barrier Reef: Present and Future Implications. The Great Barrier Reef is fundamental to the economy of Australia. This national and international icon needs to be preserved in the face of a changing world to ensure on-going sustainability of our marine resources. Ocean acidification, warming water temperatures, increased freshwater disrupt the sensitive symbiotic association of corals the major structure building organisms of reefs. Understanding how these enviro ....A Changing Climate on the Great Barrier Reef: Present and Future Implications. The Great Barrier Reef is fundamental to the economy of Australia. This national and international icon needs to be preserved in the face of a changing world to ensure on-going sustainability of our marine resources. Ocean acidification, warming water temperatures, increased freshwater disrupt the sensitive symbiotic association of corals the major structure building organisms of reefs. Understanding how these environmental stressors result in the decrease in coral health is fundamental to prevent loss of our coral reefs and an important step towards preserving them for future generations.Read moreRead less