Stress Evaluation with Non-Linear Guided Waves. This project plans to investigate a novel approach for in situ measurement of stress in structures based on an internal resonance phenomenon for nonlinear guided waves. Monitoring the stress level of critical structural components is important to ensure structural safety. The project plans to derive the requirements for this internal resonance and its dependence on stress analytically and verify them experimentally for both simple waveguides and mo ....Stress Evaluation with Non-Linear Guided Waves. This project plans to investigate a novel approach for in situ measurement of stress in structures based on an internal resonance phenomenon for nonlinear guided waves. Monitoring the stress level of critical structural components is important to ensure structural safety. The project plans to derive the requirements for this internal resonance and its dependence on stress analytically and verify them experimentally for both simple waveguides and more realistic structures. The expected outcome is the demonstration of the feasibility of a new inexpensive method for continuous monitoring of applied or thermally-induced stresses, which is of great importance in several engineering contexts, such as modern railway track rails, pipelines or pre-stressed strands in concrete structures.Read moreRead less
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Mechanisms And Therapies In Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$8,360,700.00
Summary
Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting ....Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting new knowledge through integrated research.Read moreRead less
Mathematical structure of the quantum Rabi model. This project aims to find the mathematical structure behind the quantum Rabi model, the simplest model describing the interaction between quantum light and matter. The Rabi model is the connecting link in the essential interplay between mathematics, physics, and technological applications. Solving the mathematical structure behind it is expected to form the basis for solving related and equally important models. Such models describe a qubit, the ....Mathematical structure of the quantum Rabi model. This project aims to find the mathematical structure behind the quantum Rabi model, the simplest model describing the interaction between quantum light and matter. The Rabi model is the connecting link in the essential interplay between mathematics, physics, and technological applications. Solving the mathematical structure behind it is expected to form the basis for solving related and equally important models. Such models describe a qubit, the building block of quantum information technologies, and so could realise quantum algorithms and quantum computations.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL150100019
Funder
Australian Research Council
Funding Amount
$3,041,282.00
Summary
Precision laser levitation for quantum metrology and gravitational sensing. Precision laser levitation for quantum metrology and gravitational sensing: This fellowship project aims to levitate macroscopic objects using only laser beams, to provide a new tool to test physics theories. Strong laser beams can exert sufficient force to counteract gravity and make an object levitate. In contrast to other forms of levitation, laser levitation is scatter-free and can preserve system coherence. It has s ....Precision laser levitation for quantum metrology and gravitational sensing. Precision laser levitation for quantum metrology and gravitational sensing: This fellowship project aims to levitate macroscopic objects using only laser beams, to provide a new tool to test physics theories. Strong laser beams can exert sufficient force to counteract gravity and make an object levitate. In contrast to other forms of levitation, laser levitation is scatter-free and can preserve system coherence. It has superior optical and mechanical quality factors and complete information of the system dynamics is retained. This allows laser levitation to be turned into a highly controllable and ultra-sensitive device capable of detecting minute environmental changes. This research aims to probe the relationship between quantum and gravitational physics and develop laser levitation into a precision instrument for the sensing of gravity. Laser levitation has the potential to be developed into technology for mineral exploration and environmental sensing.Read moreRead less
Dissipation and relaxation in statistical mechanics. This project studies the mathematical conditions for relaxation either to equilibrium or to steady states, which is important in predicting behaviour in diverse fields including climate modelling, materials science, nanotechnology and biology. Early career researchers will be involved in the project, gaining valuable skills in theory and simulation.
Coherent Laser Levitation for Precision Sensing and Enabling Science. When light collides with matter, it may exert a force called radiation pressure. This project aims to use radiation pressure to levitate a small mirror. Using a tripod of laser beams, it is possible to levitate and trap the mirror in a stable position. Radiation pressure has been used before to levitate, but previous work has always involved scattering light from the levitating object. This project proposes the use of a high q ....Coherent Laser Levitation for Precision Sensing and Enabling Science. When light collides with matter, it may exert a force called radiation pressure. This project aims to use radiation pressure to levitate a small mirror. Using a tripod of laser beams, it is possible to levitate and trap the mirror in a stable position. Radiation pressure has been used before to levitate, but previous work has always involved scattering light from the levitating object. This project proposes the use of a high quality mirror, allowing the collection of the reflected light and the accurate measurement and control of the position of the mirror as it floats on the laser beams. Using the unique properties of the floating mirror, it will be possible to search for signatures of quantum gravity and develop tools for ultra-precision metrology.Read moreRead less
Ionic Dispersion Forces in Physical Chemistry: Implications for pH, Electrochemistry, Nanoparticle Formation and Organic Synthesis. Our current understanding of charged systems in solution is deeply flawed . Existing theories are not predictive, mainly because they concentrate entirely on electrostatics. This proposal aims to partially rectify this by including the effects of previously neglected dispersion forces in a number of problems. These forces are responsible for much of the behaviou ....Ionic Dispersion Forces in Physical Chemistry: Implications for pH, Electrochemistry, Nanoparticle Formation and Organic Synthesis. Our current understanding of charged systems in solution is deeply flawed . Existing theories are not predictive, mainly because they concentrate entirely on electrostatics. This proposal aims to partially rectify this by including the effects of previously neglected dispersion forces in a number of problems. These forces are responsible for much of the behaviour seen in the following systems: the theory of electrolytes; electrochemistry pH and buffers; self energy effects in organic chemistry; and zeolite and nano-particle synthesis. The main outcome will be accurate and predictive theories for these systems.Read moreRead less
Properties of nonequilibrium steady states. A nonequilibrium steady state (NESS) occurs when work is performed on a system and the heat so generated is absorbed by a thermostatting mechanism. The system settles into steady state and its properties no longer change. Almost all experimental systems of interest are in a nonequilibrium state, so understanding NESSs is highly significant. Unlike time stationary equilibrium states, the distribution of microstates in a NESS cannot be described by simpl ....Properties of nonequilibrium steady states. A nonequilibrium steady state (NESS) occurs when work is performed on a system and the heat so generated is absorbed by a thermostatting mechanism. The system settles into steady state and its properties no longer change. Almost all experimental systems of interest are in a nonequilibrium state, so understanding NESSs is highly significant. Unlike time stationary equilibrium states, the distribution of microstates in a NESS cannot be described by simple closed form distributions. This project will determine properties, symmetries and extrema of NESS using concepts and theorems developed for studying transient nonequilibrium states, and will also determine if approximate, physically relevant forms of the phase space distributions can be developed.Read moreRead less
DROP DEFORMATION IN CONFINED MICROFLUIDIC GEOMETRIES. Increasingly, high technology applications in biotechnology and microtechnology industries need to process complex (non-Newtonian) fluids with dispersed particles/droplets in channels as small as several microns (microfluidics). A computational fluid dynamic model of non-Newtonian droplet deformation in microfluidic geometries will be developed, and validated using experimental measurements of the flow field in this project. The aim is to und ....DROP DEFORMATION IN CONFINED MICROFLUIDIC GEOMETRIES. Increasingly, high technology applications in biotechnology and microtechnology industries need to process complex (non-Newtonian) fluids with dispersed particles/droplets in channels as small as several microns (microfluidics). A computational fluid dynamic model of non-Newtonian droplet deformation in microfluidic geometries will be developed, and validated using experimental measurements of the flow field in this project. The aim is to understand and quantify factors influencing droplet deformation. Coupling non-Newtonian characteristics with microfluidic geometries will allow the continuous manufacture of micro-particles of specified size and shape for existing and new applications, and will provide guidance for further extending the process to nano-particle manufacture.Read moreRead less