Reprogramming Macrophage Function In The Elderly To Rescue Impaired Inflammatory Responses To Muscle Injury
Funder
National Health and Medical Research Council
Funding Amount
$410,983.00
Summary
Muscle injury in the elderly often takes longer to heal than in younger people, however the cells responsible for this delayed healing are not well understood. Key inflammatory cells required for muscle repair in young hosts are macrophages. However, during aging we have shown that macrophage function is altered, but the mechanism is unknown. This project aims to determine the mechanisms behind age-related changes to macrophages and whether they can be targeted to improve elderly muscle repair.
Wake dynamics of oscillating cylinder in steady currents. This project aims at advancing knowledge in flow/structure interactions and developing improved methodology for predicting wave and current loading on marine structures, which are vital in many practical applications such as extraction of oil and gas resources and renewable energy from the ocean. The improved methodology and much-needed database of hydrodynamic force coefficients developed through this project for estimating hydrodynamic ....Wake dynamics of oscillating cylinder in steady currents. This project aims at advancing knowledge in flow/structure interactions and developing improved methodology for predicting wave and current loading on marine structures, which are vital in many practical applications such as extraction of oil and gas resources and renewable energy from the ocean. The improved methodology and much-needed database of hydrodynamic force coefficients developed through this project for estimating hydrodynamic loading on marine structures will significantly reduce the high, costly uncertainly levels that are being experienced in the design, construction and maintenance of marine structures (and facilities) and increase the competiveness of Australian relevant industries. Read moreRead less
Mathematical and computational models for agrichemical retention on plants. Mathematical and computational models for agrichemical retention on plants. This project aims to build interactive software that simulates agrichemical spraying for multiple virtual plants reconstructed from scanned data. Mathematical modelling and computer simulation could offer an alternative to expensive experimental programs for agrichemical spraying of plants. This project will use contemporary fluid mechanics to bu ....Mathematical and computational models for agrichemical retention on plants. Mathematical and computational models for agrichemical retention on plants. This project aims to build interactive software that simulates agrichemical spraying for multiple virtual plants reconstructed from scanned data. Mathematical modelling and computer simulation could offer an alternative to expensive experimental programs for agrichemical spraying of plants. This project will use contemporary fluid mechanics to build practical mathematical models for droplet impaction, spreading and evaporation on leaf surfaces, and experimentally calibrate and validate the models. The software is expected to drive the development of agrichemical products that increase retention, minimise environmental impacts, and reduce costs for end-users.Read moreRead less
Increased Airway Smooth Muscle Mass As An Independent Determinant Of Asthma Pathogenesis And Severity
Funder
National Health and Medical Research Council
Funding Amount
$409,966.00
Summary
Asthma is a major health burden to the community. The most common form of the disease is allergic asthma and it is thought that allergic inflammation drives associated airway abnormalities including increased airway smooth muscle (ASM) mass. This study tests a new hypothesis that airway abnormalities and allergy have separate origins but combine to produce allergic asthma, and it’s the individuals with the greatest amount of ASM who develop clinically severe asthma.
Exercise As Medicine For Heart Failure: A Novel Intervention To Improve Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$665,585.00
Summary
Heart failure (HF) is a common, debilitating and expensive disease; prognosis remains poorer than for the most cancers. 30,000 Australians are diagnosed every year and 300,000 live with the HF, at an annual cost of ~$1Billion. Exercise training is effective therapy in HF, because it reverses many of the problems that contribute to the reduced lifespan and impaired quality of life of patients with HF. We will test an exciting new type of exercise that promising greater benefit, at lower risk.
Discovery Early Career Researcher Award - Grant ID: DE190100870
Funder
Australian Research Council
Funding Amount
$314,574.00
Summary
Transition to turbulence in the wake of a circular cylinder. This project aims to investigate the flow transition from laminar to turbulent in the wake of a circular cylinder subjected to steady current. The project expects to generate new knowledge on the complicated flow behaviours and physical mechanisms for flow transition to turbulence through advanced numerical modelling. Expected outcomes include a physical understanding of the flow evolution to turbulence, as well as an understanding of ....Transition to turbulence in the wake of a circular cylinder. This project aims to investigate the flow transition from laminar to turbulent in the wake of a circular cylinder subjected to steady current. The project expects to generate new knowledge on the complicated flow behaviours and physical mechanisms for flow transition to turbulence through advanced numerical modelling. Expected outcomes include a physical understanding of the flow evolution to turbulence, as well as an understanding of the laminar and turbulent flow characteristics and the suppression of turbulence in the context of flow control. The knowledge generated will be applicable to improved design and safe operations of the sub-sea transmission and communication cables used in the offshore oil and gas industry and the emerging offshore renewable energy industry.Read moreRead less
Coarse-Grid Eulerian-Eulerian Multiphase Model for Fluid Catalytic Cracking Unit. A fluid catalytic cracking (FCC) unit is an important refinery unit operation responsible for about 45% of total petrol production. The aim of this study is to improve the petrol production efficiency of Australian refineries thus allowing our country not only to maintain its self-sufficiency but also to permit lucrative exports. This will be done by optimising the performance of the FCC unit through novel computat ....Coarse-Grid Eulerian-Eulerian Multiphase Model for Fluid Catalytic Cracking Unit. A fluid catalytic cracking (FCC) unit is an important refinery unit operation responsible for about 45% of total petrol production. The aim of this study is to improve the petrol production efficiency of Australian refineries thus allowing our country not only to maintain its self-sufficiency but also to permit lucrative exports. This will be done by optimising the performance of the FCC unit through novel computational fluid dynamic simulations. The outcomes of this study will enable refiners to produce cleaner fuel (e.g., fuel with less sulphur) and decrease air pollution from the FCC unit (in the form of CO and particulates) thus helping Australia to preserve its diverse and relatively pollution-free environment.Read moreRead less
Analysis of two-phase effects in sloshing of liquids in marine tanks. One of the winners in the current greenhouse debate is natural gas, and the global market will see the need for transporting large volumes of LNG. Australia's North West Shelf is one of the largest offshore gas reserves in the world. The gas market is one of the biggest contributors for the country's economy. Australia leads the world in the use of tankers for transport of Liquefied Natural Gas (LNG). However, consistent re ....Analysis of two-phase effects in sloshing of liquids in marine tanks. One of the winners in the current greenhouse debate is natural gas, and the global market will see the need for transporting large volumes of LNG. Australia's North West Shelf is one of the largest offshore gas reserves in the world. The gas market is one of the biggest contributors for the country's economy. Australia leads the world in the use of tankers for transport of Liquefied Natural Gas (LNG). However, consistent research in LNG is lacking. This research is a fundamental inquiry into the physics of liquid sloshing and the importance of two-phase effects on sloshing. The research can provide answers that ensure safe operation and transport of LNG from Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100256
Funder
Australian Research Council
Funding Amount
$415,283.00
Summary
Extracting the hidden structure of glass from particle vibrations. Predicting the rigid behaviour of glass from its disordered, amorphous atomic structure remains a challenge in materials science. This project aims to define an innovative measure of structure based on how constrained each particle is, which can be quantified by measuring the particles’ vibrations. Using this new measure of structure, this project expects to link the microscopic structure of glass to its macroscopic properties v ....Extracting the hidden structure of glass from particle vibrations. Predicting the rigid behaviour of glass from its disordered, amorphous atomic structure remains a challenge in materials science. This project aims to define an innovative measure of structure based on how constrained each particle is, which can be quantified by measuring the particles’ vibrations. Using this new measure of structure, this project expects to link the microscopic structure of glass to its macroscopic properties via computer simulations. Expected outcomes of this project include a new methodology for characterising amorphous materials and an improved understanding of the nature of glass. This should provide significant benefits, such as an increased ability to rationally design amorphous materials with desired properties.Read moreRead less
Structural Reliability of Engineering Structures in Cyclonic Winds. This project aims to address the challenge of predicting the impact of extreme cyclonic winds on complex engineering structures. By applying advanced computational and experimental techniques the project expects to develop new insight into turbulent flows at a sub-cyclone scale and how these produce aerodynamic loads on closely spaced cylindrical structures and elements. The expected outcomes of this project include enhanced sim ....Structural Reliability of Engineering Structures in Cyclonic Winds. This project aims to address the challenge of predicting the impact of extreme cyclonic winds on complex engineering structures. By applying advanced computational and experimental techniques the project expects to develop new insight into turbulent flows at a sub-cyclone scale and how these produce aerodynamic loads on closely spaced cylindrical structures and elements. The expected outcomes of this project include enhanced simulation techniques leading to better understanding of structural vulnerability to cyclones. This should provide significant benefits, such as improved structural design and cyclone mitigation strategies applicable to both high-value engineering structures and vulnerable communities in cyclone regions.Read moreRead less