Synthesis and Characterisation of Encoded Hybrid Polymer/Gold Nanoparticles for Application in Bioassays. Bioassays are the cornerstone of in vitro diagnostic and biomedical research. This proposal will significantly contribute to these areas, by targeting an emerging technology that is crucial for their future development. The hybrid nanoparticles described in this project have the potential to replace conventional detection strategies that are currently used for bioassays. In doing so, they sh ....Synthesis and Characterisation of Encoded Hybrid Polymer/Gold Nanoparticles for Application in Bioassays. Bioassays are the cornerstone of in vitro diagnostic and biomedical research. This proposal will significantly contribute to these areas, by targeting an emerging technology that is crucial for their future development. The hybrid nanoparticles described in this project have the potential to replace conventional detection strategies that are currently used for bioassays. In doing so, they should provide significant advantages over conventional detection strategies. These advantages include increased sample throughput and conservation of biological samples, which makes possible the acceleration of patient diagnosis and drug discovery. Read moreRead less
Plant cell wall - aluminium interactions: a role in aluminium stress. Soil acidity, resulting in Al toxicity, affects production on circa 50% of Australia's intensively used agricultural land, resulting in 8.5 times more foregone agricultural income than dryland salinity (National Land and Water Resources Audit, 2001). Often, remediation with lime is not possible or affordable. By understanding Al reactions with cell wall components, we aim to identify root parameters related to Al resistance by ....Plant cell wall - aluminium interactions: a role in aluminium stress. Soil acidity, resulting in Al toxicity, affects production on circa 50% of Australia's intensively used agricultural land, resulting in 8.5 times more foregone agricultural income than dryland salinity (National Land and Water Resources Audit, 2001). Often, remediation with lime is not possible or affordable. By understanding Al reactions with cell wall components, we aim to identify root parameters related to Al resistance by plants. These parameters will be useful as selection markers to identify and breed Al-tolerant crop genotypes. This, in turn, will improve yields and farm profitability, allowing farmers to use lime to prevent further acidification. This increases sustainability of cropping operations on the 50 Mha with acid soils.Read moreRead less
Modifying and Improving Porous Sol-Gel Materials for Water Purification. XeroCoat is commercialising nanotechnology research out of UQ's Physics department. XeroCoat has received much local and international interest in its signature product 'XeroCoat'. The company is rapidly expanding and has established new research facilities with production facilities to be set-up. This will result in high technology, employment growth for Australia. Links with Flinders could see expansion into SA. The c ....Modifying and Improving Porous Sol-Gel Materials for Water Purification. XeroCoat is commercialising nanotechnology research out of UQ's Physics department. XeroCoat has received much local and international interest in its signature product 'XeroCoat'. The company is rapidly expanding and has established new research facilities with production facilities to be set-up. This will result in high technology, employment growth for Australia. Links with Flinders could see expansion into SA. The company operates in 'Sol-Gel' nanotechnology, which has huge global, academic and commercial interest. However in Australia this technology has only been serviced by Flinders, ANSTO and ANSTO's spin-out company Ceramisphere. The project will help to build a new Australian high tech industry in sol-gel nanotechnology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775650
Funder
Australian Research Council
Funding Amount
$170,000.00
Summary
Advanced multi-purpose analytical pyrolysis facility. Investment by the ARC, two WA universities, a government research agency, a CRC (and idirectly by a water utility) demonstrate the national need for this analytical facility and the broad commitment to maintain Australia's reputation in the field of analytical pyrolysis. An innovative laser micropyrolysis facility will be concurrently used with a recent commercially available unit to support research of present day and palaeo-environmental o ....Advanced multi-purpose analytical pyrolysis facility. Investment by the ARC, two WA universities, a government research agency, a CRC (and idirectly by a water utility) demonstrate the national need for this analytical facility and the broad commitment to maintain Australia's reputation in the field of analytical pyrolysis. An innovative laser micropyrolysis facility will be concurrently used with a recent commercially available unit to support research of present day and palaeo-environmental occurrences of OM, directly assisting an eclectic range of research activities including environmental protection and petroleum exploration. This facility will also aid the chemical fingerprinting of minute forensic evidence, ultimately helping to convict perpetrators of crime.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237908
Funder
Australian Research Council
Funding Amount
$637,000.00
Summary
Mass Spectrometry Instrumentation for Therapeutic Lead Discovery. Drug discovery is reliant on the application of basic research and advanced technologies to obtain solutions to human suffering caused by diseases. This application seeks funding to support the installation of state-of-the-art mass spectrometry instrumentation at Griffith University and the University of Melbourne. The requested instrumentation will enhance high quality collaborative research programs in drug discovery and eradica ....Mass Spectrometry Instrumentation for Therapeutic Lead Discovery. Drug discovery is reliant on the application of basic research and advanced technologies to obtain solutions to human suffering caused by diseases. This application seeks funding to support the installation of state-of-the-art mass spectrometry instrumentation at Griffith University and the University of Melbourne. The requested instrumentation will enhance high quality collaborative research programs in drug discovery and eradicate significant deficiencies in research infrastructure at both institutions. Access to state-of-the-art mass spectrometry instrumentation will markedly improve our international competitiveness across a broad range of biological and chemical science disciplines.Read moreRead less
Revealing molecular detail of DNA triplexes to underpin antigene technology. Variations from the classic DNA double helix structure are proposed to play key roles in a range of cellular processes, particularly gene regulation. However, the biological function and therapeutic potential of these unusual DNA structures are poorly explored, since the fundamental molecular details which govern their formation and interactions with cellular machinery are not well described. This project aims to develo ....Revealing molecular detail of DNA triplexes to underpin antigene technology. Variations from the classic DNA double helix structure are proposed to play key roles in a range of cellular processes, particularly gene regulation. However, the biological function and therapeutic potential of these unusual DNA structures are poorly explored, since the fundamental molecular details which govern their formation and interactions with cellular machinery are not well described. This project aims to develop innovative methods to investigate, and importantly modulate, DNA and RNA triple helix assembly, specificity and molecular interactions. Resulting insights will underpin novel approaches to gene regulation, principally in the context of designing new antibacterial agents to address the antibacterial resistance problem.Read moreRead less
Mass spectrometry to reveal the role of lipids in protein misfolding. This project aims to develop an integrated mass spectrometry-based approach to determine structures and dynamics of membrane associated proteins, and discover how lipids cause protein misfolding implicated in neurodegeneration. Lipid membranes may influence protein (mis)folding, aggregation and related toxicity. However, the complex and dynamic nature of the lipid-protein interactions involved means traditional methods cannot ....Mass spectrometry to reveal the role of lipids in protein misfolding. This project aims to develop an integrated mass spectrometry-based approach to determine structures and dynamics of membrane associated proteins, and discover how lipids cause protein misfolding implicated in neurodegeneration. Lipid membranes may influence protein (mis)folding, aggregation and related toxicity. However, the complex and dynamic nature of the lipid-protein interactions involved means traditional methods cannot easily characterise them, and they are poorly understood at a molecular level. The project expects to develop tools to bridge a critical gap in structural biology, while understanding lipid-protein interactions could lead to new therapies. This will ultimately provide benefits such as reduced health costs and better health outcomes.Read moreRead less