Epilepsy: Molecular Basis And Mechanisms In The Era Of Functional Genomics
Funder
National Health and Medical Research Council
Funding Amount
$12,062,533.00
Summary
The team comprises of neurologists with a special interest in epilepsy (both adult and child) molecular geneticists, physiologists and brain imaging specialists. The team leads the world in the discovery of the genetic causes of epilepsy and epilepsy associated with intellectual disability. The team will continue to identify the genes underlying epilepsy, and study how genetic variations result in the development of seizures and will continue to develop advanced imaging techniques for these stud ....The team comprises of neurologists with a special interest in epilepsy (both adult and child) molecular geneticists, physiologists and brain imaging specialists. The team leads the world in the discovery of the genetic causes of epilepsy and epilepsy associated with intellectual disability. The team will continue to identify the genes underlying epilepsy, and study how genetic variations result in the development of seizures and will continue to develop advanced imaging techniques for these studies. This will include extensive laboratory studies, including the development of mice with the exact mutations that we find in the human condition. Stateof-the-art imaging techniques with magnetic resonance and positron emission tomography are used in human subjects to further understand the effects of the mutations on the structure and function of the brain. This will allow deep understanding of how seizures develop and may lead to new diagnostic methods and treatments. The laboratory and clinical aspects of the research are tightly integrated in this internationally leading collaborative program.Read moreRead less
From The Synchrotron To The Clinic: Translation Of A Novel Functional Lung Imaging Technology
Funder
National Health and Medical Research Council
Funding Amount
$891,834.00
Summary
Our team has recently developed a synchrotron technology with a startling capacity for dynamic functional imaging that can act as a sensitive regional indicator of lung disease. We will demonstrate that this technology can be translated from the synchrotron to the lab and eventually the clinic. We will provide proof of this concept by the application of this technology to emphysema, asthma, lung cancer, cystic fibrosis lung disease and neonatal resuscitation.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560658
Funder
Australian Research Council
Funding Amount
$481,533.00
Summary
Shared Laser Facility. The Australian Shared Laser Facility (ASLF) has been providing lasers for physical chemistry research for a decade. ASLF lasers are portable and are transported between participating laboratories according to need and research priorities. Funds are sought to expand the ASLF by 3 laser systems and 2 research groups. The requested lasers provide mid-IR and deep UV wavelengths, spectral regions inaccessible with existing ASLF lasers. Access to these wavelengths is essenti ....Shared Laser Facility. The Australian Shared Laser Facility (ASLF) has been providing lasers for physical chemistry research for a decade. ASLF lasers are portable and are transported between participating laboratories according to need and research priorities. Funds are sought to expand the ASLF by 3 laser systems and 2 research groups. The requested lasers provide mid-IR and deep UV wavelengths, spectral regions inaccessible with existing ASLF lasers. Access to these wavelengths is essential for Australian research to remain at the forefront of international physical chemistry research. ASLF laboratories support a wide range of chemical research including spectroscopy, environmental chemistry, astrochemistry, and exploration of nanostructured materials.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100229
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
A prototype Scanning Helium Atom Microscope (SHeM) for soft materials. The scanning helium atom microscope (SHeM) has been a tantalising prospect since the birth of quantum physics. The SHeM would have unparalleled resolution and would be completely non-damaging; potentially revolutionising the imaging of soft delicate materials. This project will develop the first SHeM instrument in Australia to study soft matter.
Characterising Post Stroke Neuroplasticity In Humans – Identifying A Critical Window For Rehabilitation
Funder
National Health and Medical Research Council
Funding Amount
$764,419.00
Summary
Despite major investment in care for stroke patients, almost all have persisting disability. Stroke causes loss of brain cells that cannot be replaced. Some recovery is possible through compensatory mechanisms. In addition, intact cells around the stroke undergo growth that is critical for recovery. Animal studies suggest these changes take place in a “critical window” after stroke. Applying therapies in this window should improve outcomes. We will use novel approaches to define the “critical wi ....Despite major investment in care for stroke patients, almost all have persisting disability. Stroke causes loss of brain cells that cannot be replaced. Some recovery is possible through compensatory mechanisms. In addition, intact cells around the stroke undergo growth that is critical for recovery. Animal studies suggest these changes take place in a “critical window” after stroke. Applying therapies in this window should improve outcomes. We will use novel approaches to define the “critical window” in patients after strokeRead moreRead less
Very high energy gamma-ray astronomy in Australia and the development of future gamma-ray detectors. Australia contributes to the burgeoning field of ground-based gamma-ray astronomy via its involvement in the CANGAROO-III project.
I will continue the development of CANGAROO-III and establish links with the other collaborations in this field, in particular H.E.S.S., also in the southern hemisphere. Studies with CANGAROO-III of high energy gamma-ray sources such as supernova remnants and active ....Very high energy gamma-ray astronomy in Australia and the development of future gamma-ray detectors. Australia contributes to the burgeoning field of ground-based gamma-ray astronomy via its involvement in the CANGAROO-III project.
I will continue the development of CANGAROO-III and establish links with the other collaborations in this field, in particular H.E.S.S., also in the southern hemisphere. Studies with CANGAROO-III of high energy gamma-ray sources such as supernova remnants and active galaxies will finally reveal the type of particles that are accelerated in such violent regions of our universe. The development of future ground-based gamma-ray detectors beyond CANGAROO-III is also a project aim, and will expand the energy coverage of gamma-ray detectors into uncharted territory.Read moreRead less
AN INTEGRATED STUDY OF ATMOSPHERIC WAVE GENERATION AND COUPLING. Small-scale atmospheric gravity waves play an important, but not well understood, role in determining the state of the atmosphere. Observations to be made in northern Australia in 2005-2006 will bring together different kinds of radars and other instruments to study rain production processes in thunderstorms. Results will be used in a high-resolution numerical model to test wave generation by storms and to study their impact on the ....AN INTEGRATED STUDY OF ATMOSPHERIC WAVE GENERATION AND COUPLING. Small-scale atmospheric gravity waves play an important, but not well understood, role in determining the state of the atmosphere. Observations to be made in northern Australia in 2005-2006 will bring together different kinds of radars and other instruments to study rain production processes in thunderstorms. Results will be used in a high-resolution numerical model to test wave generation by storms and to study their impact on the atmosphere. The project will contribute to the improvement of weather radar measurements of rainfall and to improvement in numerical weather forecasting and climate prediction. It will provide high-quality training for postgraduate students in the use of state-of-the-art instrumentation and models.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882792
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
High Power Laser, Test Masses, Digital Control System and Vacuum System for High Optical Power Interferometry Experiments. Gravitational waves are expected to offer humanity a completely new spectrum with which to study the Universe. Australia has been a pioneer in the quest to open up this new spectrum. This project will allow Australia to play a key role in a world-wide project which aims for the first time to enable gravitational waves to be detected from black holes and neutron stars through ....High Power Laser, Test Masses, Digital Control System and Vacuum System for High Optical Power Interferometry Experiments. Gravitational waves are expected to offer humanity a completely new spectrum with which to study the Universe. Australia has been a pioneer in the quest to open up this new spectrum. This project will allow Australia to play a key role in a world-wide project which aims for the first time to enable gravitational waves to be detected from black holes and neutron stars throughout the universe. It will give Australia access to developed technologies, and will be a major boost to physical science research and education.Read moreRead less
Extending a family of garbage collectors. Garbage collection is a key component in the automatic management of storage in computer systems. It is an essential property of modern programming systems that frees the programmer from a significant error-prone task. Our interest is in garbage collection in distributed systems involving a number of networked computers. Using our novel construction methodology, we have jointly produced a family of collection algorithms that are significantly simpler and ....Extending a family of garbage collectors. Garbage collection is a key component in the automatic management of storage in computer systems. It is an essential property of modern programming systems that frees the programmer from a significant error-prone task. Our interest is in garbage collection in distributed systems involving a number of networked computers. Using our novel construction methodology, we have jointly produced a family of collection algorithms that are significantly simpler and more efficient than previous work. Here we wish to extend this family to operate effectively in a specific architecture increasingly favoured by many modern distributed high-performance computing systems.Read moreRead less