The Burden Of Late Preterm Birth On Brain Development And 2 Year Outcomes – A Prospective, Longitudinal Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$838,690.00
Summary
80% of preterm babies are born from 32-36 weeks’ gestation, and are late preterm (LPT). LPT children have more learning problems, but why this occurs is unknown. This study aims to understand the effect of LPT birth on brain development. We will do brain scans at term and assess development at 2 years of age of 200 LPT and 200 full-term children. We expect LPT babies will have subtle alterations in brain development compared with term controls which will be associated with delayed development.
Centre Of Research Excellence (CRE) In Newborn Medicine
Funder
National Health and Medical Research Council
Funding Amount
$2,622,320.00
Summary
Problems around birth are common and can have long-term implications, including into adulthood. Our goal is to improve health outcomes for all newborn babies and their families by determining factors that enhance outcome and assessing the benefits and consequences of new treatments for mothers and babies. We are world leaders in this field and are dedicated to training the next generation of health professionals in the care of newborn babies, in Australia and the rest of the world.
From Brain Maps To Mechanisms: Modeling The Pathophysiology Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
My Fellowship will develop a framework that integrates brain imaging data with mathematical models of the brain to help understand the mechanisms responsible for schizophrenia. By linking functional Magnetic Resonance Imaging (fMRI) measurements to models of their underlying causes, the work may lead to new treatments that target the specific dysfunction in individuals with this debilitating brain disorder.
A Dimensional Approach To Mapping The Risk Mechanisms Of Mental Illness
Funder
National Health and Medical Research Council
Funding Amount
$1,677,975.00
Summary
There is ongoing debate about whether current definitions of mental disorders are accurate. We will use statistical techniques to identify the core dimensions of liability for mental illness, and map how genes and brain organization drive differences between people along each dimension.
Development of Novel Two-dimensional Techniques for Magnetic Resonance In-vivo Spectroscopy. Body chemistry alters with functionality, pain, ageing and disease. These changes can be recorded by magnetic resonance (MR) spectroscopy (MRS) in vivo in a whole body MR scanner. When changes in chemistry can be recorded rapidly, and the individual species assigned, it will be possible to make a definitive diagnosis and in some cases allow the tailoring of treatment on an individual basis. This is curre ....Development of Novel Two-dimensional Techniques for Magnetic Resonance In-vivo Spectroscopy. Body chemistry alters with functionality, pain, ageing and disease. These changes can be recorded by magnetic resonance (MR) spectroscopy (MRS) in vivo in a whole body MR scanner. When changes in chemistry can be recorded rapidly, and the individual species assigned, it will be possible to make a definitive diagnosis and in some cases allow the tailoring of treatment on an individual basis. This is currently hampered by our inability to separate the composite resonances in a one dimensional MR spectrum. Research will allow two dimensional MRS to be implemented and provide detailed chemical information on human organs in vivo. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100092
Funder
Australian Research Council
Funding Amount
$1,100,000.00
Summary
Quantum microscopy facility for ultrasensitive nanoscale magnetic imaging. Investigations of 2D and van der Waals materials, biological samples, energy materials, and quantum devices on the nano- and microscale are revolutionising medicine, communications, information technology, energy production and storage by virtue of new phenomena. The new quantum microscopy facility will enable state-of-the-art capabilities in mapping chemical, magnetic, optical, electronic, and spectral properties, provid ....Quantum microscopy facility for ultrasensitive nanoscale magnetic imaging. Investigations of 2D and van der Waals materials, biological samples, energy materials, and quantum devices on the nano- and microscale are revolutionising medicine, communications, information technology, energy production and storage by virtue of new phenomena. The new quantum microscopy facility will enable state-of-the-art capabilities in mapping chemical, magnetic, optical, electronic, and spectral properties, providing cutting-edge tools that will enable breakthroughs in both existing and future multi-disciplinary projects in photonics, quantum devices, nanomaterials, nanoelectronics, biotechnology, and energy technology as key drivers of the new economy in Australia.Read moreRead less
Unified analysis of steel and composite frame structures subjected to static, thermal, earthquake and blast loading. Understanding the science of extreme loading on engineering structures is essential for their design, and increasingly with terrorism threats there is a need for assessment and strengthening of identified vulnerable critical infrastructure. Rational design paradigms have not yet matured for extreme load scenarios, and they are much-needed to protect life, limb and amenity. Austral ....Unified analysis of steel and composite frame structures subjected to static, thermal, earthquake and blast loading. Understanding the science of extreme loading on engineering structures is essential for their design, and increasingly with terrorism threats there is a need for assessment and strengthening of identified vulnerable critical infrastructure. Rational design paradigms have not yet matured for extreme load scenarios, and they are much-needed to protect life, limb and amenity. Australian research is at the forefront in steel and composite structures, and this project will strengthen Australia's positioning in the discipline by developing transparent design and assessment procedures from an efficient algorithm that delivers hands-on guidance for engineering practitioners.Read moreRead less