Minimising charge carrier recombination at silicon surfaces with improved dielectric coatings. The project will help to develop a vibrant PV industry in Australia, creating substantial employment opportunities. Spark Solar - one of the project partners - is the first dedicated PV manufacturer in Australia. There is a large and rapidly expanding overseas export market for solar panels. In addition, the large scale deployment of photovoltaic systems will help to reduce greenhouse gas emissions and ....Minimising charge carrier recombination at silicon surfaces with improved dielectric coatings. The project will help to develop a vibrant PV industry in Australia, creating substantial employment opportunities. Spark Solar - one of the project partners - is the first dedicated PV manufacturer in Australia. There is a large and rapidly expanding overseas export market for solar panels. In addition, the large scale deployment of photovoltaic systems will help to reduce greenhouse gas emissions and thus mitigate the magnitude and severity of the effects of global warming. Read moreRead less
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
Griseofulvin, A Novel Host-directed Antimalarial Drug
Funder
National Health and Medical Research Council
Funding Amount
$461,551.00
Summary
This grant is for a Phase II clinical trial to test an FDA & TGA approved drug for a new use as an antimalarial drug. The parasite uses an enzyme from the human RBC to help it replicate & early trials show this drug appears to disrupt the life cycle of the parasite. This Phase II clinical trial will test the drug on human subjects, & if successful, the drug will be a new and novel way in which to treat and prevent malarial infections in humans.
Tailoring superconducting hybrid multilayered film systems for electric and electronic applications. This project focuses on the development of new scientific and technological aspects of the fabrication, properties and operation of novel hybrid systems for revolutionizing electricity handling and electronics. It will also solve some existing problems of film structures with promising multilayer technology. Hybrid systems, often make the headlines in science and are gaining an increasingly promi ....Tailoring superconducting hybrid multilayered film systems for electric and electronic applications. This project focuses on the development of new scientific and technological aspects of the fabrication, properties and operation of novel hybrid systems for revolutionizing electricity handling and electronics. It will also solve some existing problems of film structures with promising multilayer technology. Hybrid systems, often make the headlines in science and are gaining an increasingly promising outlook in materials engineering, nanotechnology and electronics, promising eventual application in a broad range of industries. This project will establish Australia's capability at the forefront in this area. The outcomes predicted will benefit existing Australian companies and may establish new companies dealing with these hybrid systems.Read moreRead less
New Directions in Silicon Solar Cell Technology. The fabrication of pure silicon is energy intensive, but solar cells can return 10 times more energy than is used to fabricate them. By investing in the development of silicon solar cells, Australia will develop a technology capable of encapsulating its vast coal resources within pure silicon. This has the potential to create an export market of clean energy and have an explosive effect on the growth of the local industry and skilled jobs.
Th ....New Directions in Silicon Solar Cell Technology. The fabrication of pure silicon is energy intensive, but solar cells can return 10 times more energy than is used to fabricate them. By investing in the development of silicon solar cells, Australia will develop a technology capable of encapsulating its vast coal resources within pure silicon. This has the potential to create an export market of clean energy and have an explosive effect on the growth of the local industry and skilled jobs.
This project will bolster the already prominent position of Australia in the field of photovoltaic solar energy by establishing collaborations with the top international organisations in the field. It will also coordinate efforts with all the main university research groups in the country. Read moreRead less