Neural Mechanisms Of Language Facilitation In Aphasia Due To Transcranial Direct Current Stimulation.
Funder
National Health and Medical Research Council
Funding Amount
$523,192.00
Summary
This project will assess the underlying neural mechanisms by which neurostimulation improves impaired language functions after stroke (aphasia). This will be accomplished by using a novel combination of functional magnetic resonance imaging and simultaneous transcranial direct current stimulation (tDCS) administered to different brain regions. These studies will provide crucial information necessary to optimise future clinical trials that combine tDCS with language therapy.
Mitochondrially targeted anti-cancer drugs modulate the mitochondrial genome. Successful cancer management requires novel therapeutical approaches. This project will test the effect of a new class of compounds that target mitochondria, the powerhouse of the cells, where they suppress expression of mitochondrial genes. By this mechanism, cancers that are resistant to apoptosis induction can be inhibited.
Identifying Resistance Mechanisms Of Targeted BRAF Inhibitors In Metastatic Melanoma
Funder
National Health and Medical Research Council
Funding Amount
$379,015.00
Summary
Late-stage melanoma is an aggressive skin cancer for which traditional treatment strategies such as chemotherapy are ineffective. Recently, a new class of targeted drugs (BRAF inhibitors) has become the standard of care for a subset of melanoma patients; however, long term treatment success is complicated by drug resistance. This study will identify the causes of resistance with the purpose to improve targeted drug strategies and increase survival rates for late-stage melanoma patients.
Interlayer magnetoresistance of strongly correlated electron materials. The continued rapid expansion of information and entertainment technology requires new materials and devices for information storage. State of the art computer and iPod memories utilise advanced materials composed of layers of atoms, recognised by the 2007 Nobel Prize in Physics. These materials have metallic properties quite unlike those of simple metals such as copper and brass. This research will lead to a greater underst ....Interlayer magnetoresistance of strongly correlated electron materials. The continued rapid expansion of information and entertainment technology requires new materials and devices for information storage. State of the art computer and iPod memories utilise advanced materials composed of layers of atoms, recognised by the 2007 Nobel Prize in Physics. These materials have metallic properties quite unlike those of simple metals such as copper and brass. This research will lead to a greater understanding of and ability to design the next generation of materials. Australia's capacity for research and development in this scientifically challenging and technologically important field will be enhanced by this project. Read moreRead less
The theory of interferometers in nano-scale electronics. Soon the electronic circuits in computer chips will be so small that new effects due to quantum phyiscs will become important.
The proposed research will provide a better understanding of a range of nano-scale electronic devices including electron interferometers based on quantum points contacts and quantum dots.
Sepcifically, a new understanding of quantum coherent phenomena
in nano-scale interferometers will offers a potential ap ....The theory of interferometers in nano-scale electronics. Soon the electronic circuits in computer chips will be so small that new effects due to quantum phyiscs will become important.
The proposed research will provide a better understanding of a range of nano-scale electronic devices including electron interferometers based on quantum points contacts and quantum dots.
Sepcifically, a new understanding of quantum coherent phenomena
in nano-scale interferometers will offers a potential application
to other quantum technologies important to the future
of computing.
Read moreRead less
Physiologically-based Pharmacokinetics And Pharmacodynamics Of Therapeutic Stem Cells For Liver Disease
Funder
National Health and Medical Research Council
Funding Amount
$848,710.00
Summary
This project focuses on the challenging area of effective and optimal dosing cell-based therapy for liver diseases. We will investigate the fate and therapeutic effects of natural, modified and artificial therapeutic cells in the body and in liver regions using a physiologically-based kinetic model. Our key goal is advance cell therapy by providing a better understanding and dosing guidelines.
Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.
DsbA Foldases From Multidrug Resistant Pathogens As Targets For New Antimicrobials
Funder
National Health and Medical Research Council
Funding Amount
$743,401.00
Summary
Bacteria that cause common human infections, such as cystitis and diarrhoea, are now resistant to many antibiotics. If no action is taken, by 2050 antibiotic resistant infections will kill more people each year than cancer. This project aims to address this global public health crisis by characterising promising new bacterial targets and inhibitors designed to disarm multidrug resistant pathogens. Longer term this work could provide new infection therapies that are urgently needed.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882224
Funder
Australian Research Council
Funding Amount
$440,000.00
Summary
Vector Magnetic Field Facility for Nanoscale Spintronic Materials and Device Research. Electronic devices underpin a trillion dollar industry worldwide and are an essential part of modern life. Spintronics (spin-electronics) is an emergent technology that combines the electrical and magnetic properties of electrons to represent and process information. Spintronic chips are expected to be fast, versatile, capable of simultaneous data storage and processing, while at the same time consuming less ....Vector Magnetic Field Facility for Nanoscale Spintronic Materials and Device Research. Electronic devices underpin a trillion dollar industry worldwide and are an essential part of modern life. Spintronics (spin-electronics) is an emergent technology that combines the electrical and magnetic properties of electrons to represent and process information. Spintronic chips are expected to be fast, versatile, capable of simultaneous data storage and processing, while at the same time consuming less energy. Industry analysts suggest the spintronic market will exceed $10 billion. This facility will provide the critical infrastructure needed to study the electronic and magnetic properties of nanostructured materials, providing the underpinning knowledge to develop the next generation of spintronic devices.Read moreRead less