We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
Humanisation And Pre-clinical Validation Of A Therapeutic Anti-cancer Antibody
Funder
National Health and Medical Research Council
Funding Amount
$699,136.00
Summary
This grant will develop a novel antibody against a protease expressed on cancer cells. Preclinical studies, and antibody humanisation, will be performed. This project will also provide vital information on optimal therapeutic approaches with the antibody that can be ultimately taken into human trials.
ADAM Metalloprotease Inhibition For Treatment Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$770,925.00
Summary
Colorectal cancer (CRC) causes over 4000 deaths/year, typically from developing drug resistance and spreading to other organs (metastasis). These processes involve tumour cells called cancer stem cells (CSCs), which rely on specific cell surface proteins for survival and function. We are developing antibodies against one of these type of proteins, to test in mouse models of CRC. These already show promise in targeting CSCs and inhibiting drug-resistance and metastasis in mice.
A Randomised Trial Of The Augmentation Of Cognitive Behaviour Therapy With Fluoxetine For Anxious School Refusing Youth
Funder
National Health and Medical Research Council
Funding Amount
$539,191.00
Summary
School refusing youth consistently suffer from anxiety and sometimes depression. They become severely emotionally distressed when taken to school and experience social and academic difficulties in the short and long term as well as psychiatric illness in adulthood. Our program investigates whether treatment can be improved by enhancing psychotherapy (cognitive behaviour therapy) which helps over half of anxious school refusing children, with antidepressant-anxiety medication compared to placebo.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100197
Funder
Australian Research Council
Funding Amount
$1,102,947.00
Summary
Cryogenic Scanning Microwave Measurement Facility for Quantum Materials. This proposal addresses a major experimental capacity gap in Australian infrastructure for research and development of novel electronic materials and nanoscale quantum devices for future technologies. It will establish Australia's first non-contact, non-destructive, cryogenic scanning microwave microscopy facility for advanced materials characterization enabling new studies of these materials in the 2 to 300 Kelvin temperat ....Cryogenic Scanning Microwave Measurement Facility for Quantum Materials. This proposal addresses a major experimental capacity gap in Australian infrastructure for research and development of novel electronic materials and nanoscale quantum devices for future technologies. It will establish Australia's first non-contact, non-destructive, cryogenic scanning microwave microscopy facility for advanced materials characterization enabling new studies of these materials in the 2 to 300 Kelvin temperature range. The facility will provide crucial new information for the development of future quantum materials, enhancing our international competitiveness in the development of next-generation electronic materials and device technologies.Read moreRead less
Applying advanced synchrotron radiation-based techniques to determine the connection between the geometric and electronic structure of semiconductor nanocrystals. As the dimensions of nanocrystals become small unique optical and electronic properties are observed, forming the basis of many new technologies. The properties of interest depend on the fine-scale, local details of the nanocrystal structure, which may differ considerably from bulk-like. Advanced synchrotron radiation techniques wil ....Applying advanced synchrotron radiation-based techniques to determine the connection between the geometric and electronic structure of semiconductor nanocrystals. As the dimensions of nanocrystals become small unique optical and electronic properties are observed, forming the basis of many new technologies. The properties of interest depend on the fine-scale, local details of the nanocrystal structure, which may differ considerably from bulk-like. Advanced synchrotron radiation techniques will be used to investigate the relationship between the local geometric and electronic structure of semiconductor nanocrystals. Insight will be provided to their formation and stability, and the important mechanisms of their unique optical and electronic properties will be identified. Such fundamental information is necessary to facilitate innovative application of future nanocrystal technology.Read moreRead less