Mechanistic Studies on Biologically Active Iron Chelators. The need for orally effective drugs as alternatives to invasive treatment regimens such as subcutaneous infusion is an ongoing concern in health care. This is particularly true in people suffering iron overload. In many cases this condition is present at birth and thus the administration of vital iron chelation therapy via the oral route is a much preferred option. We have unearthed a novel series of candidates for iron chelation therapy ....Mechanistic Studies on Biologically Active Iron Chelators. The need for orally effective drugs as alternatives to invasive treatment regimens such as subcutaneous infusion is an ongoing concern in health care. This is particularly true in people suffering iron overload. In many cases this condition is present at birth and thus the administration of vital iron chelation therapy via the oral route is a much preferred option. We have unearthed a novel series of candidates for iron chelation therapy (the pyridine-2-carboxaldehyde isonicotinoyl hydrazone [PCIH] analogues) which show oral activity. These chelators undergo some interesting iron catalysed oxidation chemistry and it is vital that the mechanism of this reaction be elucidated to determine whether it will be of biological significance upon administration of these compounds as iron chelators.Read moreRead less
New Synthetic Routes to the Immobilisation of Mixed Valence Transition Metal Complexes on Conducting Metal Oxides. Highly coloured, electrochemically active transition metal dyes may find application electrochromic devices, where they may switch between contrasting coloured forms through a simple redox reaction. A prerequisite is that the dye be immobilised onto a solid conducting support whilst preserving the electrochemical and optical properties of the dye found in solution. This project tack ....New Synthetic Routes to the Immobilisation of Mixed Valence Transition Metal Complexes on Conducting Metal Oxides. Highly coloured, electrochemically active transition metal dyes may find application electrochromic devices, where they may switch between contrasting coloured forms through a simple redox reaction. A prerequisite is that the dye be immobilised onto a solid conducting support whilst preserving the electrochemical and optical properties of the dye found in solution. This project tackles this problem through a combination of organic and inorganic synthesis to develop new electrochromic dyes that may be attached to mesoporous titania.Read moreRead less
Ditopic receptors for the cooperative binding of cations and anions. This project is concerned with the design, synthesis and investigation of new receptor molecules that are capable of simultaneously binding metal cations and anions in a cooperative fashion. The new systems are based on a macrocyclic platform which acts as the metal binding site together with side-arms incorporating functional groups that are designed to cooperatively interact with a suitable anion. Potential applications exist ....Ditopic receptors for the cooperative binding of cations and anions. This project is concerned with the design, synthesis and investigation of new receptor molecules that are capable of simultaneously binding metal cations and anions in a cooperative fashion. The new systems are based on a macrocyclic platform which acts as the metal binding site together with side-arms incorporating functional groups that are designed to cooperatively interact with a suitable anion. Potential applications exist for this category of ditopic receptors in mineral processing where the ability to extract a metal as its metal salt may lead to more efficient solvent extraction processes.Read moreRead less
Cooperativity in Spin Crossover Systems: Memory, Magnetism and Microporosity. Spin-crossover centres are a well known form of inorganic electronic switch for which variation of temperature, pressure and irradiation leads to a change in d-electron configuration and therefore changes to structure, colour and magnetism. Here we aim to synthesise and study a wide variety of new spin-crossover systems where cooperativitiy between centres, induced by careful supramolecular design, will lead to molecul ....Cooperativity in Spin Crossover Systems: Memory, Magnetism and Microporosity. Spin-crossover centres are a well known form of inorganic electronic switch for which variation of temperature, pressure and irradiation leads to a change in d-electron configuration and therefore changes to structure, colour and magnetism. Here we aim to synthesise and study a wide variety of new spin-crossover systems where cooperativitiy between centres, induced by careful supramolecular design, will lead to molecules and materials having memory retention, magnetic ordering and/or microporosity. The significance of these aims covers several fundamental questions in the science of electronic systems. We also identify a number of potential nanochemical switching applications for the unique systems proposed.Read moreRead less
Polynuclear Spin-Crossover Molecular Switches: Host-Guest Chemistry, Magnetism and Memory. The generation of advanced nanomaterials requires both a control of nanoscale structure and the incorporation of specific properties into that structure. This project will lead to significant new developments in this area, with the assembly of complex molecular systems containing electronic switches. The unique combination of nanoscale switching and guest-binding and/or magnetic ordering in these systems ....Polynuclear Spin-Crossover Molecular Switches: Host-Guest Chemistry, Magnetism and Memory. The generation of advanced nanomaterials requires both a control of nanoscale structure and the incorporation of specific properties into that structure. This project will lead to significant new developments in this area, with the assembly of complex molecular systems containing electronic switches. The unique combination of nanoscale switching and guest-binding and/or magnetic ordering in these systems will lead to entirely new materials properties, leading in turn to fundamental advances in the science of molecular electronics and nanomaterials. Benefits of the research are wide-ranging, and include the development of innovative new technologies for molecular sensing, molecular separations, data storage and visual displays.Read moreRead less
Lie-type methods for totally disconnected groups. Groups are algebraic objects which convey symmetry, much as numbers convey size. For example, the rotations of a sphere form a group. This rotation group is one of a class known as the Lie groups that is well understood and has important applications. Totally disconnected groups arise as symmetries of network structures having nodes and a `neighbour' relation between nodes. The Australian investigator has discovered powerful methods for analysing ....Lie-type methods for totally disconnected groups. Groups are algebraic objects which convey symmetry, much as numbers convey size. For example, the rotations of a sphere form a group. This rotation group is one of a class known as the Lie groups that is well understood and has important applications. Totally disconnected groups arise as symmetries of network structures having nodes and a `neighbour' relation between nodes. The Australian investigator has discovered powerful methods for analysing totally disconnected groups which have parallels with Lie group techniques. This project will develop these parallels and establish links with international researchers on Lie groups.Read moreRead less
High-resolution in situ annealing studies of sub-micron grain structures. The proposed research is an extension of considerable ongoing collaboration between the applicants and will utilise advanced characterisation techniques to provide a more fundamental understanding than that presently available of the thermal stability of particle-containing nanocrystalline alloys. The project will reinforce the strong collaboration between our research groups and will expose Australian researchers to cutti ....High-resolution in situ annealing studies of sub-micron grain structures. The proposed research is an extension of considerable ongoing collaboration between the applicants and will utilise advanced characterisation techniques to provide a more fundamental understanding than that presently available of the thermal stability of particle-containing nanocrystalline alloys. The project will reinforce the strong collaboration between our research groups and will expose Australian researchers to cutting-edge research techniques, with particular emphasis on broadening the training experience of early career researchers. Several joint journal papers are expected from this work.
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Totally disconnected groups, representations and discrete mathematics. This project involves participation in programs at the Institute of Advanced Studies in Princeton and the nearby Center for Discrete Mathematics and Theoretical Computer Science that are designed to initiate collaborations across distinct mathematical research areas. These programs will set future research directions and could lead to innovations in computer science. Discoveries I have made in one of the research areas mean ....Totally disconnected groups, representations and discrete mathematics. This project involves participation in programs at the Institute of Advanced Studies in Princeton and the nearby Center for Discrete Mathematics and Theoretical Computer Science that are designed to initiate collaborations across distinct mathematical research areas. These programs will set future research directions and could lead to innovations in computer science. Discoveries I have made in one of the research areas mean that I may be able to make substantial contributions to these programs. Early involvement in influential programs such as these means that Australia is well placed to take advantage of developments that result and also enhances the reputation of Australian mathematics.Read moreRead less
Development of metal probes for the selective recognition of DNA. Transition metal complexes with large aromatic ligands have recently been shown to bind DNA by intercalation. However, controversy continues over their base sequence and groove selectivity. We will synthesise a range of chiral metal complexes and screen these against combinatorial oligonucleotide libraries to determine their base sequence selectivity. The information obtained will help us design better intercalators that can be us ....Development of metal probes for the selective recognition of DNA. Transition metal complexes with large aromatic ligands have recently been shown to bind DNA by intercalation. However, controversy continues over their base sequence and groove selectivity. We will synthesise a range of chiral metal complexes and screen these against combinatorial oligonucleotide libraries to determine their base sequence selectivity. The information obtained will help us design better intercalators that can be used as sensitive molecular probes and may find application as antitumour drugs. Binding interaction between the complex and DNA will be studied by NMR spectroscopy.Read moreRead less
Hecke Algebras in Algebra and Analysis. The aim of this program is to adapt techniques from harmonic analysis and operator-algebraic representation theory to study Hecke algebras arising in algebraic and geometric settings. The relevant analytic structures are C*-algebras and the fundamental question is then "Which Hecke algebras have a faithful enveloping C*-algebra?" We investigate this question, first by developing an appropriate theory of crossed products by semigroups and, second, by using ....Hecke Algebras in Algebra and Analysis. The aim of this program is to adapt techniques from harmonic analysis and operator-algebraic representation theory to study Hecke algebras arising in algebraic and geometric settings. The relevant analytic structures are C*-algebras and the fundamental question is then "Which Hecke algebras have a faithful enveloping C*-algebra?" We investigate this question, first by developing an appropriate theory of crossed products by semigroups and, second, by using the notion of topologization which enables the Hecke algebra to be studied in the context of topological groups.Read moreRead less