A New Model For The Pathogenesis Of Rheumatic Fever: Superantigen Priming Of The Immune Response To Group A Streptococci
Funder
National Health and Medical Research Council
Funding Amount
$248,820.00
Summary
Acute rheumatic fever (ARF) is now rare in developed countries. However, it remains a major problem in Aboriginal Australians in the NT where the rate of ARF is the highest in the world. This leads to high rates of rheumatic heart disease (up to 3% of individuals in some communities) and a premature mortality of over four times that for developing countries. Immunisation and improved living conditions offer a long-term solution but these remain a distant prospect. In the short and medium term, c ....Acute rheumatic fever (ARF) is now rare in developed countries. However, it remains a major problem in Aboriginal Australians in the NT where the rate of ARF is the highest in the world. This leads to high rates of rheumatic heart disease (up to 3% of individuals in some communities) and a premature mortality of over four times that for developing countries. Immunisation and improved living conditions offer a long-term solution but these remain a distant prospect. In the short and medium term, control of this ARF will partly depend on new and better treatment and prevention strategies. To achieve these goals a deeper understanding of the immune mechanisms underlying this disease is urgently needed. It is known that ARF is caused by an abnormal immune response following streptococcal infection. This leads to the production of cells called T cells that attack the body s own tissues rather than the bacteria itself. This autoimmune disease is responsible for the heart damage that underlies ARF. It is believed that this proces only occurs when susceptible individuals are infected with specific rheumatogenic strains of streptococci. However there are a number of deficiencies in this model and it is proposed that there is an additional factor responsible for the abnormal immune response in ARF. This project will explore the possibility that bacterial toxins called superantigens are the critical missing factor , by studying the immune response in ARF. Superantigens are produced by certain streptococci and staphylococci, and are potent in minute quantities causing widespread activation of the immune system. They have been found to play an important role in a number of autoimmune diseases and the type of immune response found in ARF fits well with that expected if superantigens were involved. If superantigens play an important role in causing the abnormal immune response in ARF then a number of new avenues would open for the treatment and prevention of this disease.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100049
Funder
Australian Research Council
Funding Amount
$270,000.00
Summary
Nuclear Magnetic Resonance facility for Northern Australia. Nuclear magnetic resonance facility for Northern Australia: Nuclear magnetic resonance spectroscopy is a fundamentally and critically important technique in the characterisation of organic, inorganic and biological compounds. Research areas that will be supported by this facility include organometallic chemistry and the development of new materials and analytical sensors; organic photochemistry as applied in synthesis and degradation; a ....Nuclear Magnetic Resonance facility for Northern Australia. Nuclear magnetic resonance facility for Northern Australia: Nuclear magnetic resonance spectroscopy is a fundamentally and critically important technique in the characterisation of organic, inorganic and biological compounds. Research areas that will be supported by this facility include organometallic chemistry and the development of new materials and analytical sensors; organic photochemistry as applied in synthesis and degradation; and natural products, pharmaceutical, and inorganic chemistry, where multinuclear nuclear magnetic resonance is most important and applicable in drug design, development and delivery.Read moreRead less
Estimating The Burden Of Group A Streptococcal Diseases In Victoria
Funder
National Health and Medical Research Council
Funding Amount
$386,760.00
Summary
Despite the considerable advances in the diagnosis and treatment of group A streptococcal (GAS) diseases made during the last century, the impressive spectrum of infections caused by this organism continues to have a significant impact in developed countries. This spectrum includes diseases that are mild but common (e.g. sore throat, skin sores), rare but very severe (e.g. bloodstream infections, flesh-eating bacteria) and those that are more common in developing countries and the Aboriginal pop ....Despite the considerable advances in the diagnosis and treatment of group A streptococcal (GAS) diseases made during the last century, the impressive spectrum of infections caused by this organism continues to have a significant impact in developed countries. This spectrum includes diseases that are mild but common (e.g. sore throat, skin sores), rare but very severe (e.g. bloodstream infections, flesh-eating bacteria) and those that are more common in developing countries and the Aboriginal population (e.g. rheumatic fever, kidney disease). Streptococcal sore throat remains one of the most common childhood infections, and severe group A streptococcal diseases are thought to be increasing in incidence in Australia. Yet, there are no accurate data on the incidence and costs of these or other GAS diseases in non-Aboriginal Australians, or in most other populations around the world. It is becoming more urgent to collect this data as numerous vaccine candidates are entering human trials, new approaches to the treatment of sore throat are emerging, and new strategies to treat and control the spread of severe disease are being developed. We propose a comprehensive strategy to measure the incidence, prevalence and costs of each group of GAS diseases. We will follow a group of families for 12 months to detect cases of GAS sore throat and skin sores and measure the impact on the family. We will survey children in schools to estimate the prevalence of skin sores. We will check hospital records to calculate the number of cases of rheumatic fever and kidney disease. And we will maintain surveillance for severe diseases by checking hospital and laboratory records. We will also check to see if family members of people with severe disease have the GAS bacterium in their throats. We will then compile these data into a comprehensive estimate of the burden of disease in Victoria, and estimate the cost-effectiveness of different treatment and prevention strategies.Read moreRead less
Genesis of platinum group element-rich, unconformity-style, hydrothermal mineral deposits, as inferred from a Northern Territory example. Mineral products currently provide a great deal of Australia's exports to international markets, and underpin much of our economy. However, Australia can only maintain this position through continued improvement of mineral discovery rates, particularly for high value, deep earth resources. This project aims to improve the likelihood of the discovery of higher ....Genesis of platinum group element-rich, unconformity-style, hydrothermal mineral deposits, as inferred from a Northern Territory example. Mineral products currently provide a great deal of Australia's exports to international markets, and underpin much of our economy. However, Australia can only maintain this position through continued improvement of mineral discovery rates, particularly for high value, deep earth resources. This project aims to improve the likelihood of the discovery of higher value hydrothermal orebodies. This will improve the value of mineral exports, raise exploration levels in some Australian provinces (thus stimulating economic activity in regional and industrial sectors), and help invigorate training within the geoscience arm of the university sector. Read moreRead less
ARC Research Network in Enterprise Information Infrastructure. EII targets consolidated research towards the comprehensive development & establishment of advanced information infrastructures. Its prime purpose is to provide a forum for intellectual exchange by diverse yet complementary research groups, to address the fundamental research problems faced by scientific & business communities when dealing with deployment of information technology to globally distributed, and data intensive environme ....ARC Research Network in Enterprise Information Infrastructure. EII targets consolidated research towards the comprehensive development & establishment of advanced information infrastructures. Its prime purpose is to provide a forum for intellectual exchange by diverse yet complementary research groups, to address the fundamental research problems faced by scientific & business communities when dealing with deployment of information technology to globally distributed, and data intensive environments. EII will address 3 tightly coupled research themes: Ability to interoperate across existing heterogenous platforms & applications; Efficient processing of very large data sets; Technology adoption & impact. Generic results will be applicable to e-science and large business information systems installations.Read moreRead less
Bushfire smoke and the relationship between human and landscape health. A team of landscape ecologists, environmental chemists and public health specialists will determine the ecological causes and adverse health effects of different levels of bushfire smoke in Darwin. Darwin is an ideal setting for this research because the only source of air pollution is the high incidence of controlled and uncontrolled bushfires during the dry season causing variable air quality: a preliminary study found a ....Bushfire smoke and the relationship between human and landscape health. A team of landscape ecologists, environmental chemists and public health specialists will determine the ecological causes and adverse health effects of different levels of bushfire smoke in Darwin. Darwin is an ideal setting for this research because the only source of air pollution is the high incidence of controlled and uncontrolled bushfires during the dry season causing variable air quality: a preliminary study found a link between smoke pollution levels and asthma. The findings of the proposed research will contribute to improved fire management practices to reduce injurious smoke pollution events and contribute to setting appropriate national air quality standards.Read moreRead less
Darwin Harbour corals as environmental data archives and bio-monitors. The forecast rapid population growth and industrial development of the Darwin Harbour catchment necessitates research into novel environmental monitoring techniques to aid the sustainable management of the Harbours resources. This project will develop a powerful and cost-effective bio-monitoring system by using chemical data stored in yearly growth bands of coral skeletons stretching back at least two centuries. Such data wil ....Darwin Harbour corals as environmental data archives and bio-monitors. The forecast rapid population growth and industrial development of the Darwin Harbour catchment necessitates research into novel environmental monitoring techniques to aid the sustainable management of the Harbours resources. This project will develop a powerful and cost-effective bio-monitoring system by using chemical data stored in yearly growth bands of coral skeletons stretching back at least two centuries. Such data will form a comparative baseline against which present and future coral data on pollutants released by urban, industrial and other developments can be assessed.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347582
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
South Australian Supercomputing Facility. This grant will fund the construction and installation of a state-of-the-art, heterogeneous supercomputing facility to be named the "South Australian Supercomputing Facility". The facility will be available to all of the State's academic and industrial researchers with advanced high-performance computing needs in a transparent and equitable way. Areas of research excellence to be supported by the facility include but are not limited to: research in comp ....South Australian Supercomputing Facility. This grant will fund the construction and installation of a state-of-the-art, heterogeneous supercomputing facility to be named the "South Australian Supercomputing Facility". The facility will be available to all of the State's academic and industrial researchers with advanced high-performance computing needs in a transparent and equitable way. Areas of research excellence to be supported by the facility include but are not limited to: research in computational physics, computational chemistry, geophysics, computational fluid dynamics, oil and water resource modelling, plant science, bio-informatics, space-environment research, and high-performance, parallel, and grid-based computing.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560940
Funder
Australian Research Council
Funding Amount
$229,326.00
Summary
Stable Isotope Ratio Mass Spectrometry Facility. This application for a Stable Isotope Ratio Mass Spectrometer Facility provides a focus for research collaboration and training in northern Australia. The Facility will enhance strong collaboration between organisations committed to increasing understanding of unique northern environments, and will include the Arafura Timor Research Facility, a Major National Research Facility. The Facility will contribute to studies of conservation biology, nat ....Stable Isotope Ratio Mass Spectrometry Facility. This application for a Stable Isotope Ratio Mass Spectrometer Facility provides a focus for research collaboration and training in northern Australia. The Facility will enhance strong collaboration between organisations committed to increasing understanding of unique northern environments, and will include the Arafura Timor Research Facility, a Major National Research Facility. The Facility will contribute to studies of conservation biology, natural resource management, environmental and marine science and resource development in the tropical north. It will help develop knowledge bases, innovative approaches to environmental management and sustainable development and high levels of research and research training for regional development.Read moreRead less