Tapasin And Major Histocompatibility Complex Class I Antigen Presentation
Funder
National Health and Medical Research Council
Funding Amount
$226,650.00
Summary
An effective T cell response (cellular immune response) to infections is vital to a functional immune system. Normally, proteins are cleaved into small molecules called peptides and these peptides are in turn presented by Major Histocompatibility Complex molecules to T cells. However, we have only partial understanding of what determines the choice of peptides that are finally presented to T cells. Recent research suggests that a molecule called tapasin may also influence the choice of peptides. ....An effective T cell response (cellular immune response) to infections is vital to a functional immune system. Normally, proteins are cleaved into small molecules called peptides and these peptides are in turn presented by Major Histocompatibility Complex molecules to T cells. However, we have only partial understanding of what determines the choice of peptides that are finally presented to T cells. Recent research suggests that a molecule called tapasin may also influence the choice of peptides. This research proposal aims to examine the role of tapasin in this regard. A thorough understanding of the basic principles of peptide presentation to T cells is crucial to the design of effective vaccines. Furthermore it will also broaden our understanding of immunological responses to cancer, autoimmune diseases and infections.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101178
Funder
Australian Research Council
Funding Amount
$344,324.00
Summary
Water Harvesting and the Cultural Politics of Resource Equity. This project aims to provide a new framework for understanding water equity challenges in urban South Asia. Equitable water access is an everyday struggle in this region. For example, in New Delhi, millions suffer from inadequate supplies, while the wealthy enjoy more than their share. The project plans to investigate how people respond to water stress by adopting techniques such as water harvesting. It also plans to examine the degr ....Water Harvesting and the Cultural Politics of Resource Equity. This project aims to provide a new framework for understanding water equity challenges in urban South Asia. Equitable water access is an everyday struggle in this region. For example, in New Delhi, millions suffer from inadequate supplies, while the wealthy enjoy more than their share. The project plans to investigate how people respond to water stress by adopting techniques such as water harvesting. It also plans to examine the degree to which water harvesting leads to social inclusion or exclusion. Through ethnographic examinations of the water values, resource subjectivities and power dynamics that influence the success of urban water harvesting, the projects intends to gain insights to improve regional water policy and aid effectiveness.Read moreRead less
The Kids in Communities Study: national investigation of community level effects on children's developmental outcomes. This project (a cross-disciplinary collaboration) will investigate community level factors influencing early childhood developmental outcomes using a mixed methods approach in up to 10 communities across Australia. This will result in a potential set of measures or indicators that reflect communities that are good for children.
Creating better pathways into civic participation for young homeless people through sustainable accommodation and support program models. A sustained independent living environment is a significant contributor to health and well being. This project will offer new insights into how young homeless people use and experience supported accommodation and programs. It will recommend practical models for policy development, practice and service delivery.
Radiostereometric Analysis Of The Effect Of A Large Articulation On Prosthetic Wear And Migration After Hip Replacement
Funder
National Health and Medical Research Council
Funding Amount
$192,186.00
Summary
At total hip replacement, there has been a recent trend to use prostheses with a larger ball and liner in the socket. This may decrease the risk of post-operative dislocation, but may also increase the amount of wear, leading to bone loss and loosening of prostheses, which may then require replacement. This project will use a special type of x-ray to determine whether wear and movement of these new prostheses is clinically acceptable, so that they can be used with confidence in patients.
The Risks And Benefits Of Contemporary Total Hip Replacement
Funder
National Health and Medical Research Council
Funding Amount
$493,530.00
Summary
The number of hip replacements undertaken in Australia is steadily increasing. The most common complications of hip replacements are dislocation and loosening due to bone loss around the implant, requiring complex and expensive revision surgery. This study will investigate the incidence of dislocation and, using a new diagnostic imaging technique, the incidence and amount of bone loss around a relatively new prosthetic material, the outcomes of which are not known despite its increasing use.
Symmetry in Differential Geometry. Differential geometry is a major branch of mathematics studying shape by using calculus and differential equations. This is a fundamental research project in this area, especially concerned with the interaction between geometry, differential equations, and symmetry. The mathematical notion of symmetry was already formalised early last century and nowadays lies at the very heart of mathematics and physics. Advances in this area provide essential tools in basic s ....Symmetry in Differential Geometry. Differential geometry is a major branch of mathematics studying shape by using calculus and differential equations. This is a fundamental research project in this area, especially concerned with the interaction between geometry, differential equations, and symmetry. The mathematical notion of symmetry was already formalised early last century and nowadays lies at the very heart of mathematics and physics. Advances in this area provide essential tools in basic science and unexpected technological benefits can easily arise (for example, in medical imaging). Fundamental mathematical research is absolutely necessary if Australia is to maintain a presence on the international scientific stage.
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Classification and Invariants in Complex Differential Geometry. Differential geometry is the study of shape using calculus and differential equations. This is a fundamental research project in this area. Complex differential geometry refers to geometry based on the complex numbers, generally a rich and intriguing setting. Geometries will be distinguished by the construction of suitable invariants, both algebraic and analytic. Classification problems will be solved by these means. Of particular i ....Classification and Invariants in Complex Differential Geometry. Differential geometry is the study of shape using calculus and differential equations. This is a fundamental research project in this area. Complex differential geometry refers to geometry based on the complex numbers, generally a rich and intriguing setting. Geometries will be distinguished by the construction of suitable invariants, both algebraic and analytic. Classification problems will be solved by these means. Of particular interest are geometries with a high degree of symmetry, a critical feature that pervades both mathematics and physics. Twistor theory provides the unifying theme for this project.Read moreRead less
Homotopical structures in algebraic, analytic, and equivariant geometry. This is a project for fundamental research in pure mathematics. It is focused on an emerging subfield of complex geometry concerned with spaces and maps that exhibit exceptional flexibility properties, which often go hand-in-hand with a high degree of symmetry. The project aims to develop the foundations of this new area, solve several open problems, and pursue interconnections with and applications to algebraic geometry, c ....Homotopical structures in algebraic, analytic, and equivariant geometry. This is a project for fundamental research in pure mathematics. It is focused on an emerging subfield of complex geometry concerned with spaces and maps that exhibit exceptional flexibility properties, which often go hand-in-hand with a high degree of symmetry. The project aims to develop the foundations of this new area, solve several open problems, and pursue interconnections with and applications to algebraic geometry, complex analysis, geometric invariant theory, and topology.Read moreRead less
Symmetries in real and complex geometry. This project concerns an important area of abstract modern geometry. The results and techniques of the project will lead to significant progress in this area. It will benefit the national scientific reputation, strengthen the research profile of the home institutions, and provide training to young researchers.