Antibiotic resistance is a looming public health crisis. New antibiotics with new mechanisms of action are desperately needed. The long-term goal of this research is to develop new drugs that disarm bacteria to overcome the problem of antibiotic resistance.
Preventing Mental Health Problems In Children: A Population-based Cluster Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$431,133.00
Summary
14% of Australian children develop mental health problems. As treatment is time and cost intensive, prevention is the ideal model. This can be targeted to ‘at risk’ children, but may stigmatise families and have poor uptake. This project aims to trial whether a population targeted approach embedded in universal prevention performs better than targeted prevention alone, with each approach compared to ‘usual care’. The local and state government partners will ensure sustainability, policy relevanc ....14% of Australian children develop mental health problems. As treatment is time and cost intensive, prevention is the ideal model. This can be targeted to ‘at risk’ children, but may stigmatise families and have poor uptake. This project aims to trial whether a population targeted approach embedded in universal prevention performs better than targeted prevention alone, with each approach compared to ‘usual care’. The local and state government partners will ensure sustainability, policy relevance and uptake if effectiveRead moreRead less
Improving School Transition By Improving Child Sleep: A Translational Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$745,827.00
Summary
A successful transition to school sets a child on a path for life. A poor transition can lead to early drop out, poor peer relationships and poor emotional skills. In 2008/09, we found that a brief sleep intervention for children improved key determinants of a successful transition including social-emotional functioning and parent mental health. We now plan to see if the same intervention, delivered by school nurses, can have a similar effect.
Discovery Early Career Researcher Award - Grant ID: DE140101014
Funder
Australian Research Council
Funding Amount
$349,785.00
Summary
Extending economic design to non-market settings: An experimental study of mechanism design with intention-based preferences. Mechanism design is the engineering side of economic theory, which starts with assumptions regarding human nature and builds economic systems to best maximise efficiency according to these assumptions. This project studies mechanism design in experimental settings where individuals exhibit a desire to be kind to those who have been kind to them and unkind to those who ha ....Extending economic design to non-market settings: An experimental study of mechanism design with intention-based preferences. Mechanism design is the engineering side of economic theory, which starts with assumptions regarding human nature and builds economic systems to best maximise efficiency according to these assumptions. This project studies mechanism design in experimental settings where individuals exhibit a desire to be kind to those who have been kind to them and unkind to those who have not. Such preferences are common in many non-market settings and can have dramatic effects on the efficiency of potential mechanisms. The ultimate goal of this project is to develop applied mechanisms that are robust to heterogeneity in such intention-based preferences and which can be used in bilateral exchange, contract design and many other non-market settings.Read moreRead less
Red Cell Polymorphisms and Malaria. Certain red blood cell disorders have been associated with innate protection against malaria infection. However many early studies were inconclusive. We intend to carry out a comprehensive study to investigate the effect of red blood cell differences on the invasion and/or growth of Plasmodium falciparum in vitro using improved techniques. Identification of red cell components involved in interaction with P.falciparum would give a better understanding of host ....Red Cell Polymorphisms and Malaria. Certain red blood cell disorders have been associated with innate protection against malaria infection. However many early studies were inconclusive. We intend to carry out a comprehensive study to investigate the effect of red blood cell differences on the invasion and/or growth of Plasmodium falciparum in vitro using improved techniques. Identification of red cell components involved in interaction with P.falciparum would give a better understanding of host parasite interactions which may in turn suggest novel approaches or pathways to persue. This may eventually lead to the development of novel therapeutics.
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The Centre for Research Excellence in Nursing Interventions for Hospitalised Patients will provide evidence to improve the nursing care of a broad range of hospitalised patients who are at risk of complications related to compromised skin integrity and poor pain/anxiety management. Systematic reviews and clinical trials will provide the basis for developing clinical practice guidelines to assist nurses in providing high quality care to the 3.5 million Australians admitted to hospital each year.
Economic efficiency and the provision of incentives for information acquisition and disclosure: a mechanism design approach. By uncovering what determines information acquisition, highlighting what allows experts and insiders to manipulate market outcomes, and studying the efficiency gains obtainable with the use of a variety of incentives schemes, this research will provide valuable insights for public policy concerning information diffusion and market transparency.
Discovery Early Career Researcher Award - Grant ID: DE130101191
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Formation of the osteocyte network in bone matrix. The formation of new bone, which occurs throughout life for bone renewal and acutely after fractures, entraps a network of cells that can detect micro-damage and direct repair mechanisms. Mathematical and computational methods will be used to understand how this network can lead to a self-detecting and self-repairing biomaterial.
Bulk Mg based hydrogen storage alloys with faster activation. Bulk Mg based hydrogen storage alloys with faster activation. This project aims to improve the performance and efficiency of manufacture of magnesium-based hydrogen storage alloys, making them more cost competitive and widely useable. A hydrogen economy will reduce greenhouse gas emissions and improve air quality in urban areas. The expected outcomes are an understanding of the mechanisms governing the activation process, a necessary ....Bulk Mg based hydrogen storage alloys with faster activation. Bulk Mg based hydrogen storage alloys with faster activation. This project aims to improve the performance and efficiency of manufacture of magnesium-based hydrogen storage alloys, making them more cost competitive and widely useable. A hydrogen economy will reduce greenhouse gas emissions and improve air quality in urban areas. The expected outcomes are an understanding of the mechanisms governing the activation process, a necessary step in manufacture, and techniques to exploit these mechanisms to minimise the activation time. This is expected to develop competitive, bulk magnesium-based hydrogen storage alloys for effective and safe hydrogen storage systems.Read moreRead less