Discovery Early Career Researcher Award - Grant ID: DE210101144
Funder
Australian Research Council
Funding Amount
$429,450.00
Summary
Understanding crosstalks between Natural Killer cells and Dendritic Cells. This project aims to investigate the interactions between two populations of immune cells: natural killer cells and dendritic cells. This proposal will advance basic knowledge in immunology by innovating in considering the heterogeneity and diversity of these two immune populations and combining interdisciplinary approaches using cutting-edge technologies. Expected outcomes from this proposal include the identification of ....Understanding crosstalks between Natural Killer cells and Dendritic Cells. This project aims to investigate the interactions between two populations of immune cells: natural killer cells and dendritic cells. This proposal will advance basic knowledge in immunology by innovating in considering the heterogeneity and diversity of these two immune populations and combining interdisciplinary approaches using cutting-edge technologies. Expected outcomes from this proposal include the identification of new immunoregulatory pathways, the development of new scientific theories, and enhancement of Australia’s research capacity through international collaborations and student training. This project will provide significant benefits such as the identification of biological targets for development of new biotechnologies. Read moreRead less
Towards Robust Hydrogen Electrode for High-Rate Alkaline Electrolysis. This project aims to develop robust, efficient porous hybrid hydrogen electrodes for electrochemical hydrogen production in anion exchange membrane water electrolyser. anion exchange membrane water electrolyser powered by renewable energy has emerged as a key avenue towards clean hydrogen with zero carbon footprint. However, the electrochemical turnover on the hydrogen electrode has been significantly hindered by the sluggish ....Towards Robust Hydrogen Electrode for High-Rate Alkaline Electrolysis. This project aims to develop robust, efficient porous hybrid hydrogen electrodes for electrochemical hydrogen production in anion exchange membrane water electrolyser. anion exchange membrane water electrolyser powered by renewable energy has emerged as a key avenue towards clean hydrogen with zero carbon footprint. However, the electrochemical turnover on the hydrogen electrode has been significantly hindered by the sluggish reaction kinetics in alkaline solution. The project is expected to generate cost-effective hydrogen electrodes for hydrogen electrolyzers, advanced knowledge in the electrode material engineering, electrochemical reaction mechanistic insights, and eventually promoted development of disruptive electrolysis technology.Read moreRead less
Click chemistry to reveal how neurons and glia shape perineuronal nets . The extracellular matrix (ECM) and its perineuronal nets (which are net-like structures with holes wrapped around neurons) are largely underexplored, despite representing a remarkable 20% of the brain’s total volume and having been suggested to be involved in many brain functions. Interestingly, digestion of the ECM improves learning and memory, but deficits return once the ECM has reformed. However, how this ECM remodellin ....Click chemistry to reveal how neurons and glia shape perineuronal nets . The extracellular matrix (ECM) and its perineuronal nets (which are net-like structures with holes wrapped around neurons) are largely underexplored, despite representing a remarkable 20% of the brain’s total volume and having been suggested to be involved in many brain functions. Interestingly, digestion of the ECM improves learning and memory, but deficits return once the ECM has reformed. However, how this ECM remodelling is organised at a cell-type level is not understood. Here we aim to close this knowledge gap, using cutting-edge technology including bioconjugation and ultrasound-mediated cargo delivery. Together, this project aims to contribute to a deeper understanding of this major brain compartment in neuronal function. Read moreRead less
Adrenomedullin: a specific regulator of venous vessel integrity. Arteries and veins display different adhesive properties, which enable them to fulfil their physiological roles. We are yet to understand the mechanisms that establish and maintain adhesive function in different vessel types. We have discovered that signalling by the peptide Adrenomedullin (ADM) is a key mediator of adhesion, only in veins but not arteries. This project aims to utilise innovative models (zebrafish, mouse and bioeng ....Adrenomedullin: a specific regulator of venous vessel integrity. Arteries and veins display different adhesive properties, which enable them to fulfil their physiological roles. We are yet to understand the mechanisms that establish and maintain adhesive function in different vessel types. We have discovered that signalling by the peptide Adrenomedullin (ADM) is a key mediator of adhesion, only in veins but not arteries. This project aims to utilise innovative models (zebrafish, mouse and bioengineered vessels) to identify the biochemical and mechanical mechanisms by which ADM controls venous adhesion. Outcomes will improve our understanding on how vessel integrity is controlled across vessel types and will expand the scope of Australian research by informing efforts to vascularise engineered tissues.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100190
Funder
Australian Research Council
Funding Amount
$363,996.00
Summary
Auction design with behavioural bidders. This project aims to incorporate behavioural elements from psychology into the economic analysis of auctions. The project will address discrepancies between traditional economic analysis of auctions based on fully rational bidders, and evidence from psychology and behavioural economics which demonstrates systemic departures from rational decision-making. This will expand realism in economic analysis and contribute new insights for the design of relevant, ....Auction design with behavioural bidders. This project aims to incorporate behavioural elements from psychology into the economic analysis of auctions. The project will address discrepancies between traditional economic analysis of auctions based on fully rational bidders, and evidence from psychology and behavioural economics which demonstrates systemic departures from rational decision-making. This will expand realism in economic analysis and contribute new insights for the design of relevant, real-world auctions such as real-estate auctions or internet auctions. The project outcomes are expected to enhance the efficient allocation of resources, improve our understanding of how different rules affect buyers' well-being and help design fairer auctions.Read moreRead less
Information and market design: mediation and analogical argumentation. This project aims to increase knowledge of how judicious disclosure of information facilitates economic exchange and social interactions and to shed light on how mediation can be an effective mode of dispute resolution. The project seeks to uncover how analogical arguments can be persuasive and determine social outcomes as well as provide guidance for advocates and decision makers on the best way to persuade and counteract mi ....Information and market design: mediation and analogical argumentation. This project aims to increase knowledge of how judicious disclosure of information facilitates economic exchange and social interactions and to shed light on how mediation can be an effective mode of dispute resolution. The project seeks to uncover how analogical arguments can be persuasive and determine social outcomes as well as provide guidance for advocates and decision makers on the best way to persuade and counteract misleading persuasion practices. Besides producing significant new knowledge, the project promises to inform future innovative economic, social and cultural developments of benefit to the Australian and international community.Read moreRead less
RhoA signaling: the nanoscale mechanisms of mechanochemical regulation. This project aims to elucidate a new paradigm for regulating cell signals at the nanoscale level. Cell signalling involves the coordination of multi-molecular networks at the plasma membrane, the interface between the cell and its external environment. These are often thought to involve the assembly of multimolecular complexes through the action of protein scaffolds. This project will focus on how the contractile regulator, ....RhoA signaling: the nanoscale mechanisms of mechanochemical regulation. This project aims to elucidate a new paradigm for regulating cell signals at the nanoscale level. Cell signalling involves the coordination of multi-molecular networks at the plasma membrane, the interface between the cell and its external environment. These are often thought to involve the assembly of multimolecular complexes through the action of protein scaffolds. This project will focus on how the contractile regulator, anillin, controls RhoA signalling by kinetic regulation. In particular, how nanoscale clustering of anillin by the dynamic actomyosin cytoskeleton modulates RhoA signalling for contractility and tissue homeostasis. The outcomes of this project are first and foremost fundamental understanding of how cells communicate with one another.Read moreRead less
Defining mechanisms behind the formation of hierarchical vascular networks. Blood vessels form complex branched networks composed of arteries, capillaries and veins. The development and maintenance of different vessel systems (arteries and veins) is dependent on cell adherence properties within each vessel, yet how these are established and maintained remains unknown. This project aims to analyse the differences in junctional dynamics between sprouting arteries and veins, and to identify arteria ....Defining mechanisms behind the formation of hierarchical vascular networks. Blood vessels form complex branched networks composed of arteries, capillaries and veins. The development and maintenance of different vessel systems (arteries and veins) is dependent on cell adherence properties within each vessel, yet how these are established and maintained remains unknown. This project aims to analyse the differences in junctional dynamics between sprouting arteries and veins, and to identify arterial and venous signalling networks that make and maintain vessel identity. This project will reveal how adhesiveness is regulated in order to make a hierarchical, functional vascular network, with implications for engineering of functional, vascularised organs in the biotech sector.Read moreRead less
Redesigning Landcare policy to better coordinate across landholders. This project aims to study how landscape-sensitive economic incentives and social norms can be leveraged to enhance the short- and long-term effectiveness of conservation programs. It will yield new knowledge for innovative designs in conservation contracting that is urgently needed to address worsening environmental threats in Australia and worldwide. In collaboration with Nobel laureate Vernon Smith’s team, new methods and pr ....Redesigning Landcare policy to better coordinate across landholders. This project aims to study how landscape-sensitive economic incentives and social norms can be leveraged to enhance the short- and long-term effectiveness of conservation programs. It will yield new knowledge for innovative designs in conservation contracting that is urgently needed to address worsening environmental threats in Australia and worldwide. In collaboration with Nobel laureate Vernon Smith’s team, new methods and protocols will improve our ability to generate better data and better understand how social and incentive mechanisms can constructively interact to facilitate collaborative environmental action. Results will help make the achievement of environmental targets and the use of public funds more cost-effective. Read moreRead less