Methods to infer dense genomic information from sparsely genotyped populations. Prediction of phenotype based on DNA polymorphisms or sequence has important applications such as prediction of disease risk in human medicine and prediction of genetic value in plant or animal breeding. This project will enhance precision and lower the cost of association studies leading to substantial increase in accuracy of such predictions. This will allow more effective genetic improvement, particularly of diff ....Methods to infer dense genomic information from sparsely genotyped populations. Prediction of phenotype based on DNA polymorphisms or sequence has important applications such as prediction of disease risk in human medicine and prediction of genetic value in plant or animal breeding. This project will enhance precision and lower the cost of association studies leading to substantial increase in accuracy of such predictions. This will allow more effective genetic improvement, particularly of difficult but important traits such as disease resistance, reduced green-house gas emissions and product quality. The same methods can be extended to improve genetic improvement in plants and better prediction of human disease risk. Read moreRead less
Identifying the diversity and evolution of loci associated with adaptation to aridity/heat and salinity in ancient cereal crops. This project will use ancient grains of wheat, barley and rye to find 'lost' genetic diversity at key genes associated with resistance to aridity, salt and disease. This project will make the proteins of key genes, and study their interaction with the environment over time by measuring ions in the grains to reveal the ancient environmental conditions.
Genomic selection: a new frontier for higher rates of genetic gain in wheat. The historical rates of genetic gain in wheat production are insufficient to meet the world's future needs for wheat-based food. Genomic selection (GS) is the most likely candidate tool that is capable of delivering the required level of genetic gain. This project will develop data-sets and statistical methods to implement GS in wheat.
Developing Zn-dense, high-yielding wheat by molecular marker technology. The objective of this project is to identify pathways leading to the accumulation of zinc — an important element for human nutrition — in wheat. The project aims to provide biochemical and molecular markers for breeding programs that will facilitate the selection of superior breeding lines for improved human nutrition and seed health. This project builds on studies using a wheat diversity panel with 90 000 gene-based single ....Developing Zn-dense, high-yielding wheat by molecular marker technology. The objective of this project is to identify pathways leading to the accumulation of zinc — an important element for human nutrition — in wheat. The project aims to provide biochemical and molecular markers for breeding programs that will facilitate the selection of superior breeding lines for improved human nutrition and seed health. This project builds on studies using a wheat diversity panel with 90 000 gene-based single nucleotide polymorphism (SNP) markers, where zinc–SNP associations were identified. The project also builds on recent studies that show particular metabolites and macronutrients around anthesis are linked to improved grain zinc concentration at maturity.Read moreRead less
Enabling Molecular Plant Breeding for Drought Adaptation Using Genome-to-Phenome Modelling Technologies. Effective molecular plant breeding for improved water productivity of sorghum would generate significant economic and social benefits for rural communities in NE Australia. There is a significant opportunity to expand the sorghum industry in the region. Despite the global financial crisis, global demand for meat continues to increase, generating strong demand from intensive livestock industri ....Enabling Molecular Plant Breeding for Drought Adaptation Using Genome-to-Phenome Modelling Technologies. Effective molecular plant breeding for improved water productivity of sorghum would generate significant economic and social benefits for rural communities in NE Australia. There is a significant opportunity to expand the sorghum industry in the region. Despite the global financial crisis, global demand for meat continues to increase, generating strong demand from intensive livestock industries for feed grain. Price is projected to return to high levels given continuing use of major feed grains for biofuel. A 10% increase in sorghum production would add net value of $48M annually, much via employment. The scientific content of this project positions Australia at the leading edge globally in this emerging research field. Read moreRead less
Exploring genetic diversity to identify new heat tolerance genes in wheat. This project aims to improve the selection and development of heat-tolerant wheat varieties. Heatwaves seriously reduce wheat yields worldwide, and the situation will worsen with climate variation. This project aims to apply a broad genetic scan to identify the main chromosome regions controlling heat tolerance at the sensitive flowering stage in Australian and European wheat varieties. It is expected that this knowledge ....Exploring genetic diversity to identify new heat tolerance genes in wheat. This project aims to improve the selection and development of heat-tolerant wheat varieties. Heatwaves seriously reduce wheat yields worldwide, and the situation will worsen with climate variation. This project aims to apply a broad genetic scan to identify the main chromosome regions controlling heat tolerance at the sensitive flowering stage in Australian and European wheat varieties. It is expected that this knowledge will deliver crucial breeders’ tools to select heat-tolerant varieties. The project also aims to identify genes most likely to control tolerance at these chromosome locations using gene expression profiling data, trait associations and knowledge of heat-tolerance genes from other species. It is expected that these genes will reveal molecular mechanisms of heat tolerance and create new opportunities to engineer superior levels of tolerance in cereals.Read moreRead less
Genome-wide determination of Puccinia psidii s.l. rust resistance in eucalypts. Recently, guava rust was detected in Australia, posing significant risks to native flora, plantations, and timber exports. Scientists from The University of Melbourne and Victorian Department of Primary Industries together with tree breeders, forest growers and forest managers aim to use tree genomics rust resistance breeding to enable management and operational responses and inform policy development.
TraitCapture: Genomic modelling for plant phenomics under environmental stress. This project aims to develop software to integrate new hyper-spectral and 3D growth models of plant phenomics with population genomics to identify heritable developmental traits across varied environments. Genome wide association studies aim to then be used to identify causal genes. Functional structural plant models incorporating genetic variation will be used to predict growth under simulated stress environments. ....TraitCapture: Genomic modelling for plant phenomics under environmental stress. This project aims to develop software to integrate new hyper-spectral and 3D growth models of plant phenomics with population genomics to identify heritable developmental traits across varied environments. Genome wide association studies aim to then be used to identify causal genes. Functional structural plant models incorporating genetic variation will be used to predict growth under simulated stress environments. The research team unites international industry, the Australian Plant Phenomics Facility, and university statistical geneticists. TraitCapture software will use open standards applicable to both controlled and field environments enabling plant breeders to pre-select adaptive traits to increase crop productivity under environmental stress.Read moreRead less
Establishing novel breeding methods for canola improvement. It is imperative to ensure reliable food production in the coming years of climate change and increasing population. Genomics offers the greatest potential to increase food production. This project will apply genomic selection methods to accelerate canola oilseed breeding to ensure continued increases in production of this important food and national export.
Advanced animal breeding in aquaculture: using genome-wide molecular breeding values for rapid animal improvement in the silver-lipped pearl oyster. The primary impediment to achieving rapid genetic progress in aquaculture is an inability to accurately and rapidly identify high-performance animals for selection as parents in animal breeding programs. This project aims to develop an innovative genomic selection breeding system for the silver-lipped pearl oyster to overcome current limitations ass ....Advanced animal breeding in aquaculture: using genome-wide molecular breeding values for rapid animal improvement in the silver-lipped pearl oyster. The primary impediment to achieving rapid genetic progress in aquaculture is an inability to accurately and rapidly identify high-performance animals for selection as parents in animal breeding programs. This project aims to develop an innovative genomic selection breeding system for the silver-lipped pearl oyster to overcome current limitations associated with traditional animal improvement methods. The use of genomic selection will not only transform the Australian pearl oyster industry, but it will also showcase the potential of genomic selection in aquaculture globally. Furthermore, knowledge gained from this project can also be applied to a variety of other Australian aquaculture species to accelerate the uptake of this technology.Read moreRead less