Antigen Selection In The MHC-restricted Cellular Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$175,570.00
Summary
The body's white cells eliminate microorganisms through the actions of immune lymphocytes and other cells which conspire to kill and neutralise these unwanted guests. When microorganisms hide inside the cells of the body they are still detected by a set of T lymphocytes which have specific receptors for scrutinising the surface of cells for any changes which might signal an intracellular infection. The immune system is ever vigilant in its search for signs of infection which are generally appare ....The body's white cells eliminate microorganisms through the actions of immune lymphocytes and other cells which conspire to kill and neutralise these unwanted guests. When microorganisms hide inside the cells of the body they are still detected by a set of T lymphocytes which have specific receptors for scrutinising the surface of cells for any changes which might signal an intracellular infection. The immune system is ever vigilant in its search for signs of infection which are generally apparent when molecules called antigens are released by microorganisms and captured by the body's cells. This activates lymphocytes resulting in an immune response capable of eliminating the microorganisms. Scrutiny of the body's cells by lymphocytes occurs continuously even when there is no infection present in the body. Following infection of a cell, microbial antigens reveal the infection by their appearance on the cell surface where they are detected by the immune system's lymphocytes. This occurs through a mechanism called antigen presentation. During antigen presentation the proteins inside the cell, including those of any invading microorganism, are first degraded into shorter molecules called peptides. This event is called antigen processing. A fraction of the peptides created by antigen processing are captured by specialised receptors present on all cells. These receptors are called HLA or histocompatibility molecules. This project examines the molecular events which mediate the capture of peptide antigens by HLA molecules. The main focus is on those peptide antigens which elicit killer T cell responses by the immune system. A knowledge of how these peptides are selected for presentation and how they are captured and carried to the cell surface is fundamental to understanding immune responses to microorganisms, tumours, allergens, transplants and self tissues as in autoimmunity. Therefore the study is of great general relevance.Read moreRead less
The Impact of Changing Climatic Conditions inferred from the Isotope Abundances of Trace Metals in Global Ice Sheets and Glaciers. In this project Greenland and Antarctic ice-cores more than 3 km long will be used to investigate climatic variation extending back more that 4 complete glacial cycles. Some of these ice-cores include sections of refrozen water formed from sub-glacial Antarctic lake water. This project will use naturally occurring lead and strontium isotopic tracers to fingerprint ....The Impact of Changing Climatic Conditions inferred from the Isotope Abundances of Trace Metals in Global Ice Sheets and Glaciers. In this project Greenland and Antarctic ice-cores more than 3 km long will be used to investigate climatic variation extending back more that 4 complete glacial cycles. Some of these ice-cores include sections of refrozen water formed from sub-glacial Antarctic lake water. This project will use naturally occurring lead and strontium isotopic tracers to fingerprint impurities in the ice, because they have the potential to simultaneously signal the timing and location of past episodes of climate change. This will lead to an improvement in our understanding of the processes that cause these changes.Read moreRead less
Impact Of An Ivermectin Mass Drug Administration Program Against Endemic Scabies And Strongyloidiasis
Funder
National Health and Medical Research Council
Funding Amount
$1,289,786.00
Summary
Overseas studies suggest sustainable and long term benefits can be obtained through the use of ivermectin in mass drug administration programs to control parasitic infections. Our study will be a critical first step in establishing if such a program can be successful in a remote Indigenous community setting, where the disease burden from scabies and strongyloidiasis (threadworm infections) is very high.
Special Research Initiatives - Grant ID: SR0354560
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
AUSTRALIAN RESEARCH NETWORK IN ANALYTICAL SCIENCE (ARNAS). The initiative will provide the foundations for the establishment of an Australian Research Network in Analytical Science (ARNAS), which will bring together fundamental researchers and practitioners working in quantitative chemical analysis and related areas. ARNAS will provide national coordination of research in analytical science, coverage of the newest developments, pooling of expertise and research facilities and resources, and rap ....AUSTRALIAN RESEARCH NETWORK IN ANALYTICAL SCIENCE (ARNAS). The initiative will provide the foundations for the establishment of an Australian Research Network in Analytical Science (ARNAS), which will bring together fundamental researchers and practitioners working in quantitative chemical analysis and related areas. ARNAS will provide national coordination of research in analytical science, coverage of the newest developments, pooling of expertise and research facilities and resources, and rapid dissemination of outcomes. ARNAS will significantly advance the national research agenda for analytical science by improving awareness of research activities and expertise, providing enhanced education and opportunities for the next generation of analytical scientists, and by stimulating new international collaborations.Read moreRead less
Estimating Time Since Death: Application of Radionuclide Technology. This study will
- advance the knowledge base and expertise of Australian anthropologists and forensic scientists through the development of an accurate method for determining time since death from skeletal remains
- directly assist police and forensic forces in their fight against crime, which is fundamental in ensuring the national security of Australia
- promote Australia as a leader in the design of new evidence-bas ....Estimating Time Since Death: Application of Radionuclide Technology. This study will
- advance the knowledge base and expertise of Australian anthropologists and forensic scientists through the development of an accurate method for determining time since death from skeletal remains
- directly assist police and forensic forces in their fight against crime, which is fundamental in ensuring the national security of Australia
- promote Australia as a leader in the design of new evidence-based forensic methods
- raise the profile of Australian scientists in international investigations involving skeletal remains (e.g. Bali bombing, Boxing Day Tsunami, Human Rights Issues)
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Thermal enhancement strategies and development of a high-performance micro-scale heat exchanger for thermoelectric refrigeration with large cooling loads. Traditional refrigeration essentially utilises CFC-refrigerants which are potent atmospheric pollutants causing widespread ecological damage. Devoid of such adversities, electronic heat pumping mechanism of thermoelectric principle offers a practical ?CFC-free? alternative for conventional cooling methods. While the current thermoelectric te ....Thermal enhancement strategies and development of a high-performance micro-scale heat exchanger for thermoelectric refrigeration with large cooling loads. Traditional refrigeration essentially utilises CFC-refrigerants which are potent atmospheric pollutants causing widespread ecological damage. Devoid of such adversities, electronic heat pumping mechanism of thermoelectric principle offers a practical ?CFC-free? alternative for conventional cooling methods. While the current thermoelectric technology adequately meets light cooling demand, its potential for heavy-duty refrigeration is critically undermined by ill-developed methods for dissipating heat from thermoelectric modules to coolants, and remains grossly under-utilised. The proposed work will devise novel heat transfer techniques for raising thermoelectric cooling thresholds to suit large heat loads and develop a thermally enhanced micro-scale heat exchanger for application in commercial thermoelectric refrigeration.Read moreRead less
Tackling the resurgences of life, advanced dating tools of oils by sophisticated molecular and isotopic analyses from major geological events. Evidence of Earth’s biogeochemical evolution is uniquely recorded in sediments and petroleum, as are the mechanisms of life’s recovery from mass extinction caused by past catastrophes. Pioneering ageing techniques will be tested on ancient sediments, low temperature mineral fabrics and petroleum leading to the exploration of new energy sources.
Discovery Early Career Researcher Award - Grant ID: DE130101533
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
A risk-based approach to natural gas hydrates in oil and gas production. Like a cholesterol for oil and gas pipelines, gas hydrates are ice-like deposits that completely block the flow during production and are expensive to prevent as well as dangerous to remove. This proposal provides a risk-based approach to hydrate management that will increase the viability of natural gas production from fields in deep water.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989351
Funder
Australian Research Council
Funding Amount
$425,000.00
Summary
High Resolution Mass Spectrometry Facility. The research that will be supported by this vital infrastructure impacts on the sustainable environment through understanding the process of seed germination and the human condition through new drugs for the treatment of cancer and Parkinson's disease. Fundamental science will also be addressed particularly in the fields of photonics and the nature of interactions between matter.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668536
Funder
Australian Research Council
Funding Amount
$485,000.00
Summary
Western Australian Facility for High Throughput Biological and Organic Gas Chromatography-Mass Spectrometry. Disciplines such as pharmaceuticals, plant protection, mineral extraction, and conservation all need to separate, identify and quantify molecules. The method of choice for small molecules (< 500 amu) is gas chromatography and mass spectrometry (GC-MS). A broad range of laboratories in WA are using GC-MS, but the equipment is fully utilised, outdated and limiting progress. This applicatio ....Western Australian Facility for High Throughput Biological and Organic Gas Chromatography-Mass Spectrometry. Disciplines such as pharmaceuticals, plant protection, mineral extraction, and conservation all need to separate, identify and quantify molecules. The method of choice for small molecules (< 500 amu) is gas chromatography and mass spectrometry (GC-MS). A broad range of laboratories in WA are using GC-MS, but the equipment is fully utilised, outdated and limiting progress. This application seeks to purchase research grade GC-MS equipment with order-of-magnitude improvements in mass range, sample throughput, discrimination and data handling capacities. This equipment will transform capabilities and will enhance projects supporting the minerals and agricultural industries and enhance biodiversity conservation efforts.Read moreRead less