Whole Body Vibration For Osteoporosis: Shaking Up Our Treatment Options
Funder
National Health and Medical Research Council
Funding Amount
$961,017.00
Summary
Our aim is to examine the ability of vibration alone and in combination with osteoporosis drugs to reduce hip fracture in postmenopausal women. In Australia, 1 in 2 women >60yrs, will sustain an osteoporotic fracture. Only drugs notably decrease fracture; however none are entirely effective and some patients don’t respond. Whole body vibration has emerged as a potentially effective therapy. A combination of vibration and drugs may enhance the effects of both and revolutionise treatment.
Development Of Site-specific Predictive Assay For Periodontal Disease Progression Using Mass Spectrometric &RT- PCR Anal
Funder
National Health and Medical Research Council
Funding Amount
$150,000.00
Summary
In this project new DNA-based technology will be developed to determine the numbers of specific bacteria in the dental plaque of patients. The project will also use new mass spectrometric analysis techniques for the determination of compounds in gingival crevicular fluid, an exudate from the gums. These two techniques will be used in a clinical trial to determine if periodontal (gum) disease progression can be predicted by changes in the numbers of bacteria or in the composition of gingival crev ....In this project new DNA-based technology will be developed to determine the numbers of specific bacteria in the dental plaque of patients. The project will also use new mass spectrometric analysis techniques for the determination of compounds in gingival crevicular fluid, an exudate from the gums. These two techniques will be used in a clinical trial to determine if periodontal (gum) disease progression can be predicted by changes in the numbers of bacteria or in the composition of gingival crevicular fluid. This could provide insight into the development of periodontal disease and lead to new preventive and treatment regimes.Read moreRead less
Glycosyltransferase Effectors Of Enteropathogenic E. Coli And Salmonella
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
This project aims to characterise the mechanisms of disease caused by bacterial pathogens including Salmonella and enteropathogenic E. coli. These pathogens cause a significant amount of diarrhoeal disease and mortality worldwide particularly in infants and in countries where water sanitation is poor. I aim to investigate the specific mechanisms the bacteria employ to manipulate and avoid our immune response during infection in order to better understand and combat diarrhoeal disease.
Assessment of the new technologies to maximise the internal energy efficiency by modelling the energy flows in Victorian power stations. Increased internal energy efficiency will reduce the CO2 emissions and increase the profit margin for the power stations. The aim of the proposed research is to investigate the internal energy efficiency in the brown coal fired power stations by modelling the internal energy flows to reveal the potentials in the 'waste' heat streams in the power stations, and t ....Assessment of the new technologies to maximise the internal energy efficiency by modelling the energy flows in Victorian power stations. Increased internal energy efficiency will reduce the CO2 emissions and increase the profit margin for the power stations. The aim of the proposed research is to investigate the internal energy efficiency in the brown coal fired power stations by modelling the internal energy flows to reveal the potentials in the 'waste' heat streams in the power stations, and to assess new waste heat recovery measures for the power industry. The proposed research, supported by the entire Victorian power generation industry, will help the industry to achieve their green house gas emission reduction target set by the Federal Government.
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Simulating two-phase electrodynamic flows in droplet-based microfluidic circuit elements. The knowledge, data and analysis tools developed within this project will facilitate the economical production of electrodynamically controlled integrated droplet-based microfluidic devices for critical high-demand applications such as: genome sequencing; protein evolution, synthesis and crystallisation; micro-structured pharmaceuticals; disposable devices for biomedical analysis; portable point-of-entry (b ....Simulating two-phase electrodynamic flows in droplet-based microfluidic circuit elements. The knowledge, data and analysis tools developed within this project will facilitate the economical production of electrodynamically controlled integrated droplet-based microfluidic devices for critical high-demand applications such as: genome sequencing; protein evolution, synthesis and crystallisation; micro-structured pharmaceuticals; disposable devices for biomedical analysis; portable point-of-entry (biochem)security analysis devices. Hence this project is an investment in enabling technologies to benefit Australia's growing biotech, pharmaceutical and micro/nanotechnology sectors. Tangible community benefits (e.g., in improved diagnostic technologies, pharmaceuticals) will result.Read moreRead less
Process scalability and performance prediction of Viscous Transfer Micro Turbines for use as miniaturised power supplies. This project aims to predict the performance and scalability of viscous transfer turbines. The work will be carried out with Micromachines Ltd., a firm developing working turbines with 50 mm rotors. The goal of the research is to gain an understanding of the scaling laws for these turbines, in order to predict their performance. Viscous transfer turbines have a very simple di ....Process scalability and performance prediction of Viscous Transfer Micro Turbines for use as miniaturised power supplies. This project aims to predict the performance and scalability of viscous transfer turbines. The work will be carried out with Micromachines Ltd., a firm developing working turbines with 50 mm rotors. The goal of the research is to gain an understanding of the scaling laws for these turbines, in order to predict their performance. Viscous transfer turbines have a very simple disc construction making them ideal for manufacturing as small-scale units (with a 5 mm rotor). Small enough to replace batteries, but with a higher power output, they would provide the need for higher power output devices to replace batteries.Read moreRead less
DROP DEFORMATION IN CONFINED MICROFLUIDIC GEOMETRIES. Increasingly, high technology applications in biotechnology and microtechnology industries need to process complex (non-Newtonian) fluids with dispersed particles/droplets in channels as small as several microns (microfluidics). A computational fluid dynamic model of non-Newtonian droplet deformation in microfluidic geometries will be developed, and validated using experimental measurements of the flow field in this project. The aim is to und ....DROP DEFORMATION IN CONFINED MICROFLUIDIC GEOMETRIES. Increasingly, high technology applications in biotechnology and microtechnology industries need to process complex (non-Newtonian) fluids with dispersed particles/droplets in channels as small as several microns (microfluidics). A computational fluid dynamic model of non-Newtonian droplet deformation in microfluidic geometries will be developed, and validated using experimental measurements of the flow field in this project. The aim is to understand and quantify factors influencing droplet deformation. Coupling non-Newtonian characteristics with microfluidic geometries will allow the continuous manufacture of micro-particles of specified size and shape for existing and new applications, and will provide guidance for further extending the process to nano-particle manufacture.Read moreRead less
Electro-viscous effects on pressure-driven liquid flow in microchannels. Australian biotechnology, information technology and food technology industries will benefit from the development of new tailored micro- and nano-fluidic devices for processing of non-Newtonian fluids. The efficiency of functional elements such as valves, pumps, mixers, reactors, heat exchangers can be optimised for specific fluids by understanding the coupling between the fluid properties, the device geometry, surface cha ....Electro-viscous effects on pressure-driven liquid flow in microchannels. Australian biotechnology, information technology and food technology industries will benefit from the development of new tailored micro- and nano-fluidic devices for processing of non-Newtonian fluids. The efficiency of functional elements such as valves, pumps, mixers, reactors, heat exchangers can be optimised for specific fluids by understanding the coupling between the fluid properties, the device geometry, surface charge, and the numerical predictions. This understanding will complement development in related projects on non-Newtonian drop and particle formation in microfluidic flows which envisage continuous particle manufacture for novel materials possessing programmable, enhanced functional properties.Read moreRead less
Design and Construction of Novel Thermal Interferometers. This project aims to invent thermal interferometers, which take advantage of the interference effect of thermal waves to display standing temperature interference fringes on a surface of prism. Two coherent thermal waves are input from two other surfaces of the prism in a similar way as an optical interferometer does. By inventing such a device, the project will demonstrate a new instrumentation mechanism which may lead to its applicati ....Design and Construction of Novel Thermal Interferometers. This project aims to invent thermal interferometers, which take advantage of the interference effect of thermal waves to display standing temperature interference fringes on a surface of prism. Two coherent thermal waves are input from two other surfaces of the prism in a similar way as an optical interferometer does. By inventing such a device, the project will demonstrate a new instrumentation mechanism which may lead to its application in medical technology. Furthermore, the principle of temperature localisation due to thermal interference may provide new insights to account for the cause of conformational changes of proteins that result in diseases.Read moreRead less
Ink jet microfluidic spray drier for making high quality microencapsulated bioactive particles and nanosized particles. The proposal addresses National Research Priority area 3 (Frontier Technology). This work will develop a new, simple and effective method for producing designer smart particles that have better functional properties as well as improved uniformity for application in the food and pharmaceutical industries. The project will train graduates who will be able to make a high-level con ....Ink jet microfluidic spray drier for making high quality microencapsulated bioactive particles and nanosized particles. The proposal addresses National Research Priority area 3 (Frontier Technology). This work will develop a new, simple and effective method for producing designer smart particles that have better functional properties as well as improved uniformity for application in the food and pharmaceutical industries. The project will train graduates who will be able to make a high-level contribution to these Australian industries. This will also mark a development in Australia¡¯s nanotechnology capability in the bio-area.Read moreRead less