Improving The Management Of Diabetes In Pregnancy In Remote Australia
Funder
National Health and Medical Research Council
Funding Amount
$2,117,449.00
Summary
This study aims to optimise the management of diabetes in pregnancy (both gestational diabetes and pre-existing type 2 diabetes) and post-partum follow-up of these high risk women in order to reduce the risk of future chronic disease among women and their children. The proposal involves scale-up of successful initiatives that we have developed as part of the NT DIP Partnership, scale-up within the Northern Territory (NT) and to Far North Queensland (FNQ).
Periconceptual Foundations For A Healthy Start To Life.
Funder
National Health and Medical Research Council
Funding Amount
$11,022,802.00
Summary
Preconception and early pregnancy is a critical time for a women's health and that of her future child. New research suggests that a woman's genetic potential, her lifestyle and the physical and socioeconomic environment in which she lives, and her biological and social relationship with her male partner, all impact on the long term health of her baby. Abnormal events around the time of conception and in early pregnancy can predispose a newborn to later occurrence, in adult life, of conditions i ....Preconception and early pregnancy is a critical time for a women's health and that of her future child. New research suggests that a woman's genetic potential, her lifestyle and the physical and socioeconomic environment in which she lives, and her biological and social relationship with her male partner, all impact on the long term health of her baby. Abnormal events around the time of conception and in early pregnancy can predispose a newborn to later occurrence, in adult life, of conditions including heart disease, diabetes, obesity and stroke. These adverse events originate in the way that eggs and sperm develop, the uterus is prepared for implantation, the attachment of the early embryo to the lining of the uterus and subsequent growth of the placenta. This Program will study the early life events that promote or limit development of a baby's true potential for successful and healthy life. A better understanding of how lifestyle and environment interact with genes and biology to facilitate optimal growth of the fetus will underpin new preventative measures and therapeutic treatments for infertility, miscarriage and other reproductive disorders. The knowledge gained will inform health policy and clinical practise to improve reproductive health in all Australian women and promote healthy development in all Australian children. The team of researchers is a world-class group of clinicians, scientists and epidemiologists who have made major contributions to our understanding of this area. This team will interface with clinics and hospitals that engage with women prior to and during pregnancy, while having the influence to alter clinical and health practices as well as public health policies. The team will utilize the latest, most technologically advanced laboratory methods and clinical skills, including gene profiling, imaging of early pregnancy, randomised clinical trials and access to the best epidemiological and statistical assessments.Read moreRead less
Coverage with Evidence Development: Application to pharmaceutical reimbursement decisions. Some new medicines produce only a small improvement in health but have considerable costs. When these medicines are trialled on only small numbers of people, uncertainty results about the value of the medicine, which can create problems for decision makers. Funding medicines where there is uncertainty may lead to harm when medicines are later found to be unsafe, or waste millions of dollars when they are ....Coverage with Evidence Development: Application to pharmaceutical reimbursement decisions. Some new medicines produce only a small improvement in health but have considerable costs. When these medicines are trialled on only small numbers of people, uncertainty results about the value of the medicine, which can create problems for decision makers. Funding medicines where there is uncertainty may lead to harm when medicines are later found to be unsafe, or waste millions of dollars when they are overpriced relative to effectiveness. Not funding medicines may disadvantage patients in whom the medicines are effective. Methods to enable access to medicines while reducing uncertainty will offer significant benefit to patients, clinicians and taxpayers. Read moreRead less
A new quality of life instrument with older people for economic evaluation. This project aims to develop and validate a new preference-based quality-of-life instrument with applications in aged-care. The new instrument will be developed with older people receiving aged care services, and will focus upon incorporating their values into the measurement and valuation of quality of life for economic evaluation. The new instrument will have immediate applications in quality assessment and economic ev ....A new quality of life instrument with older people for economic evaluation. This project aims to develop and validate a new preference-based quality-of-life instrument with applications in aged-care. The new instrument will be developed with older people receiving aged care services, and will focus upon incorporating their values into the measurement and valuation of quality of life for economic evaluation. The new instrument will have immediate applications in quality assessment and economic evaluation, improving the quality of life and wellbeing of older Australians, and will assist in determining the relative cost effectiveness of new and existing services.
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Pregnancy And Neonatal Diabetes Outcomes In Remote Australia (PANDORA) Cohort
Funder
National Health and Medical Research Council
Funding Amount
$2,395,410.00
Summary
The PANDORA study is a longitudinal birth cohort study recruited from a clinical register of Northern Territory women with diabetes in pregnancy (DIP). We will also recruit a comparator group of mothers without DIP and babies. Follow-up of mothers and infants to 3 years post-delivery will be from medical records, questionnaires and clinical assessment. Rates of progression to type 2 diabetes will be assessed among mothers, and growth, feeding patterns and diabetes risk markers among infants.
Dental Health Services Research For Improved Oral Health Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$2,641,484.00
Summary
This research will generate new knowledge to improve health outcomes by investigating expenditure and financing of dental care, dental practice performance, and the impact of dental services on oral health outcomes. This is needed for health policy to deliver dental care that promotes good oral health, to identify characteristics of the dental delivery system that deliver productive outputs with good outcomes, and testing oral health outcomes in relation to the type of dental care received.
Turning Points: Breaking Intergenerational Cycles Of Intimate Partner Abuse And Social Adversity
Funder
National Health and Medical Research Council
Funding Amount
$1,328,354.00
Summary
Intimate partner abuse (IPA) is estimated to affect one in four women at some stage in their lives, and to impact on the lives of at least one million Australian children annually. This study will investigate the extent to which exposure to intimate partner abuse during pregnancy and in the first 12 months postpartum predicts child outcomes in middle childhood. The study will provide foundations for better targeting and tailoring of early intervention strategies to support children at risk of ad ....Intimate partner abuse (IPA) is estimated to affect one in four women at some stage in their lives, and to impact on the lives of at least one million Australian children annually. This study will investigate the extent to which exposure to intimate partner abuse during pregnancy and in the first 12 months postpartum predicts child outcomes in middle childhood. The study will provide foundations for better targeting and tailoring of early intervention strategies to support children at risk of adverse outcomes.Read moreRead less
Health Impacts Of Sleep Apnea In Australian Men- A Longitudinal Population Study.
Funder
National Health and Medical Research Council
Funding Amount
$312,056.00
Summary
Obstructive sleep apnea (OSA) is very common, seen in 60-70% of men over 40 years old. OSA is linked to a number of serious conditions, e.g. heart disease and diabetes. However, we don't know which men are at risk of long term complications from OSA. Our aim is to follow-up men from a community sample of 1000 men who had sleep studies in 2010 to help identify who is at risk of poor health from OSA.
Effectiveness of Intervention Strategies to Promote Physical Activity Among Insufficiently Active Adults. This project will determine the cost-effectiveness of 2 types of physical activity (PA) interventions based around the workplace. 480 participants will be randomly assigned to PA intervention groups or controls. Interventions are either a (1) self-regulated, pedometer-based program or a (2) semi-structured, 40-day initiation to more moderately-vigorous PA. Both are designed to increase self- ....Effectiveness of Intervention Strategies to Promote Physical Activity Among Insufficiently Active Adults. This project will determine the cost-effectiveness of 2 types of physical activity (PA) interventions based around the workplace. 480 participants will be randomly assigned to PA intervention groups or controls. Interventions are either a (1) self-regulated, pedometer-based program or a (2) semi-structured, 40-day initiation to more moderately-vigorous PA. Both are designed to increase self-efficacy and impact on positive PA behaviours. Long-term, behavioural change and job-related outcomes will be evaluated by following participants for 12 months after the interventions.Read moreRead less
Changing Places: An exploration of factors influencing the move of older people from retirement villages to residential aged care. Older Australians living in retirement villages, an increasing community population segment, make choices both about the place at which they live, and the support needed to optimise health and wellbeing at that place. Changing places for this group often involves moving from retirement village to residential aged care facility. This study explores how and why this ....Changing Places: An exploration of factors influencing the move of older people from retirement villages to residential aged care. Older Australians living in retirement villages, an increasing community population segment, make choices both about the place at which they live, and the support needed to optimise health and wellbeing at that place. Changing places for this group often involves moving from retirement village to residential aged care facility. This study explores how and why this change occurs, how it might be avoided, and, when the move is unavoidable what can improve the moving process. Findings will inform innovations in policy, service and health care provision designed to facilitate appropriate ageing in place congruent with best practice principles.Read moreRead less