Endocrine And Molecular Regulation Of Placental CRH Expression
Funder
National Health and Medical Research Council
Funding Amount
$466,980.00
Summary
Approximately 70% of infant death is associated with premature birth. Preterm birth occurs in 6-10% of pregnancies, and there has been no reduction in the rates of premature birth in the last 30 years. This is largely because we remain ignorant of how normal and abnormal birth is controlled. Understanding the physiology of human pregnancy is a critical step in the development of ways to detect and prevent preterm birth. Our group has demonstrated a link between production of a hormone (corticotr ....Approximately 70% of infant death is associated with premature birth. Preterm birth occurs in 6-10% of pregnancies, and there has been no reduction in the rates of premature birth in the last 30 years. This is largely because we remain ignorant of how normal and abnormal birth is controlled. Understanding the physiology of human pregnancy is a critical step in the development of ways to detect and prevent preterm birth. Our group has demonstrated a link between production of a hormone (corticotrophin releasing hormone, CRH) in the placenta and the length of time the baby is carried in the mother. In women who will deliver prematurely a rise in CRH occurs earlier in the pregnancy and more rapidly, while in women who deliver late the rise occurs more slowly. This work has given rise to the concept of a biological clock that determines the length of time the fetus will be carried by the mother before birth, and in which production of CRH in the placenta plays a central role. We have been studying how the CRH gene is controlled in placental cells. We have discovered some regions in the DNA of the CRH gene which have important roles in controlling how much CRH is made by the placenta. The experiments described in this research project will determine the molecular mechanisms that control the production of CRH in the human placenta. This will be done in two ways: (1) by examining the DNA sequences involved in controlling expression of the CRH gene and (2) by identifying the proteins that actually perform the regulating functions that result in either increased or decreased amounts of CRH being produced by the placenta. This important information will help us better understand how normal and abnormal birth is controlled, and from that knowledge new ways to detect and prevent premature birth can be invented.Read moreRead less
Closing The Gap: Early Childhood Sustained Home Visiting For Families Of Aboriginal Infants In An Urban Community
Funder
National Health and Medical Research Council
Funding Amount
$2,244,402.00
Summary
The study aims to determine whether a sustained structured nurse home visiting (SSNVH) program is effective for Aboriginal families. In the context of increased government investment in home visiting programs for Indigenous children, this study will help to answer three critical questions: (1) Does SSNHV result in improved outcomes for Aboriginal infants? (2) Is SSNHV equally effective for Aboriginal and non-Aboriginal infants?(3) What are the issues in adaptation and implementation?
Determinants of children's physical activity and sedentary behaviour: a follow-up study from early childhood. This project investigates changes in preschool children's physical activity and sedentary behaviour, and influences on these changes, during the important period of transition to school. It will provide important information on how we might assist children to be more active, thereby avoiding the detrimental health and social outcomes of inactivity.
Child health and developmental inequities: Evidence for precision policy. The project aims to use cutting edge analytic approaches applied to existing data to identify how policy interventions related to parents’ mental health, preschool programs, and the built environment can be optimised to reduce inequities in children’s mental, academic, and physical health outcomes. The project will be informed by our partners and advisers from across government portfolios and service delivery, ensuring tha ....Child health and developmental inequities: Evidence for precision policy. The project aims to use cutting edge analytic approaches applied to existing data to identify how policy interventions related to parents’ mental health, preschool programs, and the built environment can be optimised to reduce inequities in children’s mental, academic, and physical health outcomes. The project will be informed by our partners and advisers from across government portfolios and service delivery, ensuring that the evidence generated has contemporary policy relevance. The project expects to identify clear and actionable policy pathways to reduce child inequities in Australia, which can benefit decision makers by helping them to direct limited public funds towards intervention opportunities that will have the greatest impact.Read moreRead less
The Kids in Communities Study: national investigation of community level effects on children's developmental outcomes. This project (a cross-disciplinary collaboration) will investigate community level factors influencing early childhood developmental outcomes using a mixed methods approach in up to 10 communities across Australia. This will result in a potential set of measures or indicators that reflect communities that are good for children.
Cluster randomised control trial of an early childhood literacy intervention to improve literacy and language outcomes in preschool aged children. Reading failure disproportionately affects disadvantaged communities in Australia, with nearly 40% of poor children failing to read at the minimum reading benchmark in Grade three. Of more concern is the disturbing trend indicating that prior to first grade, socioeconomic status (SES) differences also exist in important antecedents of reading such as ....Cluster randomised control trial of an early childhood literacy intervention to improve literacy and language outcomes in preschool aged children. Reading failure disproportionately affects disadvantaged communities in Australia, with nearly 40% of poor children failing to read at the minimum reading benchmark in Grade three. Of more concern is the disturbing trend indicating that prior to first grade, socioeconomic status (SES) differences also exist in important antecedents of reading such as letter knowledge and phonological processing skills, yet there remains no universal program to promote early language and literacy practices in the primary care setting. We propose a cluster randomised controlled trial to evaluate the efficacy of a multi injection intervention to improve literacy outcomes of children in disadvantaged communities.Read moreRead less
A study investigating the feasibility of implementing a national approach to child and family health services. Understanding and strengthening the way in which universal health services are provided to pregnant women, children and families has the potential to impact over a million Australian families annually. The findings of this study will have national application as federal, state and territory governments work towards implementing a national approach to child and family health services. Th ....A study investigating the feasibility of implementing a national approach to child and family health services. Understanding and strengthening the way in which universal health services are provided to pregnant women, children and families has the potential to impact over a million Australian families annually. The findings of this study will have national application as federal, state and territory governments work towards implementing a national approach to child and family health services. The findings will inform effective multidisciplinary collaboration and service integration, address service gaps and duplication and lead to increased access to services. This study will generate new knowledge about characteristics of organisations, service delivery and professions that facilitate or hinder innovation.Read moreRead less
Integrated Kids Hubs - Ensuring Equity of Access for Children. The Integrated Kids Hubs - Ensuring Equity of Access for Children project aims to determine if integrated Hubs are effective in increasing access to child and family services for disadvantaged urban and regional families with children aged 3 years and under, thus improving early identification of developmental vulnerability, parental wellbeing and capacity, and addressing unmet psychosocial needs. If these issues are not identified a ....Integrated Kids Hubs - Ensuring Equity of Access for Children. The Integrated Kids Hubs - Ensuring Equity of Access for Children project aims to determine if integrated Hubs are effective in increasing access to child and family services for disadvantaged urban and regional families with children aged 3 years and under, thus improving early identification of developmental vulnerability, parental wellbeing and capacity, and addressing unmet psychosocial needs. If these issues are not identified and addressed early, these children will go on to struggle in school and life. We will use a pragmatic trial design (meaning the research is embedded in our usual practice), determine the social return on investment, and establish what is needed to scale up the Hubs across NSW and Australia.Read moreRead less
Social practices of oral health in Australian preschool children. The aim of the study is to explore "social practices" of oral health in Australian (Aboriginal and non-Aboriginal) preschool children. We use this emerging theory to move away from focusing on individuals and individual behaviour (and blame) to identify and map social practices: actions, materials and meanings families attribute to
child’s oral health. Expected project outcomes include identifying practices promoting or underminin ....Social practices of oral health in Australian preschool children. The aim of the study is to explore "social practices" of oral health in Australian (Aboriginal and non-Aboriginal) preschool children. We use this emerging theory to move away from focusing on individuals and individual behaviour (and blame) to identify and map social practices: actions, materials and meanings families attribute to
child’s oral health. Expected project outcomes include identifying practices promoting or undermining children’s oral health that can inform upstream and downstream policy directions and practices to improve health outcomes. This offers a new approach to "wicked" problems such as oral health where extensive
effort has not reduced morbidity and cost despite rhetoric that oral health is preventable.Read moreRead less
Promoting healthy eating, active play and sustainability awareness in early childhood curricula: Addressing the Ben10™ problem. A pedagogical communication strategy has been developed to allow early childhood educators to design curriculum interventions that support children’s learning about healthy eating, the importance of active play and the sustainability consequences of their food and toy selections. The aim of this study is to conduct a randomised trial to evaluate the efficacy of the curr ....Promoting healthy eating, active play and sustainability awareness in early childhood curricula: Addressing the Ben10™ problem. A pedagogical communication strategy has been developed to allow early childhood educators to design curriculum interventions that support children’s learning about healthy eating, the importance of active play and the sustainability consequences of their food and toy selections. The aim of this study is to conduct a randomised trial to evaluate the efficacy of the curriculum interventions, developed by teachers using this pedagogical communication strategy, on children’s knowledge about healthy eating, active play and the sustainability consequences of their food and toy selections. This project connects strongly with the learning outcomes of the National Early Years Learning Framework and the Australian Curriculum to be implemented in 2014.Read moreRead less