An efficient approach to the computation of bacterial evolutionary distance. This project aims to apply advanced mathematical tools to improve our understanding of bacterial evolution. Bacteria account for as much total Earth biomass as all plant species put together, and have an unparalleled ability to evolve quickly and adapt to changing environments. Unfortunately, the existing mathematical models used to model bacterial evolution are generally computationally intractable. This project will r ....An efficient approach to the computation of bacterial evolutionary distance. This project aims to apply advanced mathematical tools to improve our understanding of bacterial evolution. Bacteria account for as much total Earth biomass as all plant species put together, and have an unparalleled ability to evolve quickly and adapt to changing environments. Unfortunately, the existing mathematical models used to model bacterial evolution are generally computationally intractable. This project will rectify this situation by using representation theory to transform combinatorial group theory into linear algebra, allowing for the application of advanced methods of numeric approximation. This will provide a better understanding of how bacteria evolve and improve our ability to manage their impact.Read moreRead less
Algebraically informed models of biological sequence evolution. To make sense of the patterns they see in the natural world, biologists across fields as diverse as genetics, epidemiology and biogeography need an accurate picture of evolutionary history. DNA sequences provide an exciting means to establish this picture of the past, but to decode it successfully requires mathematical models of how DNA evolves. Mathematical inconsistencies have been identified with current approaches. In particular ....Algebraically informed models of biological sequence evolution. To make sense of the patterns they see in the natural world, biologists across fields as diverse as genetics, epidemiology and biogeography need an accurate picture of evolutionary history. DNA sequences provide an exciting means to establish this picture of the past, but to decode it successfully requires mathematical models of how DNA evolves. Mathematical inconsistencies have been identified with current approaches. In particular, understanding the effect of natural selection in different parts of the tree of life requires models that behave robustly in the face of shifting evolutionary processes. This project aims to use insights from algebraic methods to construct mathematically consistent models of wide biological utility.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100423
Funder
Australian Research Council
Funding Amount
$369,061.00
Summary
Group theory and phylogenetics: exploiting symmetry to uncover evolutionary history. Using advanced algebra, structural symmetries inherent in phylogenetic methods will be studied and improved approaches will be derived. DNA sequences contain a wealth of information about evolutionary events that occurred millions of years ago, but extracting this information requires the application of robust methods.
Reading the Social Future of the Australian Red Cross Blood Service. This project investigates how and if the Australian Red Cross Blood Service (ARCBS) is building social capital. It does this by interrogating existing practices and operations at the ARCBS and by surveying donors and non-donors. This project aims to develop a Deleuzian critique of the notion of social capital.
Vulnerability, autonomy and justice. Vulnerable people require assistance and care. But what are our responsibilities in relation to the vulnerable? And how can we provide assistance and care while avoiding stereotyping or paternalism? This research will advance ethical theory and be useful in solving practical problems in health research and policy.
Viscous Effects in Free-Surface Flows. Australia has a proud record of achievement in the field of free-surface fluid mechanics. This project will build and extend these research achievements. It will provide new information about how fluid layers overturn and mix, which is an important process in oceanography. It will examine the sloshing behaviour of fluid in moving storage tanks, which is important in fuel transport and building design. The project will develop new mathematical methods fo ....Viscous Effects in Free-Surface Flows. Australia has a proud record of achievement in the field of free-surface fluid mechanics. This project will build and extend these research achievements. It will provide new information about how fluid layers overturn and mix, which is an important process in oceanography. It will examine the sloshing behaviour of fluid in moving storage tanks, which is important in fuel transport and building design. The project will develop new mathematical methods for solving these problems accurately, and will contribute to the next generation of research mathematicians in Australia. Read moreRead less
Structure and informatics of the genetic code. Recent advances in biotechnology have seen its emergence as a highly
quantitative, numerically-based discipline. To exploit the available
data to the full will require, alongside computing power, new
analytical techniques. This project aims to develop such techniques,
by handling the systematics of the genetic code with methods derived
from theoretical physics and chemistry. Expected outcomes include a
dynamical (quantum field theory) model ....Structure and informatics of the genetic code. Recent advances in biotechnology have seen its emergence as a highly
quantitative, numerically-based discipline. To exploit the available
data to the full will require, alongside computing power, new
analytical techniques. This project aims to develop such techniques,
by handling the systematics of the genetic code with methods derived
from theoretical physics and chemistry. Expected outcomes include a
dynamical (quantum field theory) model of phylogenetic branching,
analyses of nucleic acid structure and content (spin chain models of
RNA binding and of DNA open reading frames), and insights into the
origin of the code itself (via numerical codon similarity measures).
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An Evaluation of Suspended Sentences of Imprisonment. A suspended sentence is a fixed term of imprisonment, the execution of which has been suspended in whole or in part. It is widely used in most Australian jurisdictions. A conflict between public and legal perceptions about the severity of this sanction contributes to a lack of public confidence in the criminal justice system and makes abolition or restrictions on the use of suspended sentences a real possibility when governments feel pressure ....An Evaluation of Suspended Sentences of Imprisonment. A suspended sentence is a fixed term of imprisonment, the execution of which has been suspended in whole or in part. It is widely used in most Australian jurisdictions. A conflict between public and legal perceptions about the severity of this sanction contributes to a lack of public confidence in the criminal justice system and makes abolition or restrictions on the use of suspended sentences a real possibility when governments feel pressured to be tough on crime. This project aims to explore the use of the suspended sentence and to evaluate its efficacy as an alternative to imprisonment.
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Advanced matrix-analytic methods with applications. Over the last twenty-five years, matrix-analytic methods have proved to be very successful in formulating and analysing certain classes of stochastic models. Motivated by applications, this project will investigate more advanced matrix-analytic methods than have hitherto been studied.
Place, Commonality and the Human: Towards a New Philosophical Anthropology. This project proposes a new philosophical vision of what it means to be human. Combining historical and conceptual approaches, the project aims to develop a new philosophical anthropology that centres on understanding human beings in terms of both place and commonality. This account is designed to provide the basis for a rethought conception of the ethics that are bound to human life and that understands the ethical as e ....Place, Commonality and the Human: Towards a New Philosophical Anthropology. This project proposes a new philosophical vision of what it means to be human. Combining historical and conceptual approaches, the project aims to develop a new philosophical anthropology that centres on understanding human beings in terms of both place and commonality. This account is designed to provide the basis for a rethought conception of the ethics that are bound to human life and that understands the ethical as essentially a matter of judgment rather than prescriptive rule. Given the centrality of the concept of the human to any thinking about our contemporary situation, the project would have both applied and interdisciplinary relevance.Read moreRead less