Innovative mathematical modelling to determine incorporation of gene therapy in different cell lineages; Human Immunodeficiency Virus (HIV) as a model setting. Gene therapy is a promising therapeutic that is being developed to address genetic diseases and viral infections such as Human Immunodeficiency Virus (HIV). This project will produce mathematical models of how gene therapy delivered to one type of cell can differentiate into the desired end target and impact disease.
Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the p ....Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the patient.
The strong mathematical focus of this project, and its application to a promising approach against HIV, will place Australia at the forefront of the mathematics of gene research and contribute to the National Priority Area of Promoting and Maintaining Good Health and the Priority Goal of Preventative Healthcare.
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Bodies in space. By investigating how a change in shape of the human body can produce a change in spatial orientation, the project will bring a fundamental advance of knowledge in the intersection of applied mathematics, sports science and mechanical engineering. These knowledge advances will lead to a novel theory regarding the control of the aerial dynamics of athletes, specifically springboard and platform divers. When applied in collaboration with world class Australian athletes, this theory ....Bodies in space. By investigating how a change in shape of the human body can produce a change in spatial orientation, the project will bring a fundamental advance of knowledge in the intersection of applied mathematics, sports science and mechanical engineering. These knowledge advances will lead to a novel theory regarding the control of the aerial dynamics of athletes, specifically springboard and platform divers. When applied in collaboration with world class Australian athletes, this theory will result in innovative platform and springboard diving techniques and improved performance. The reach of new insights generated by this work extends to many other fields, including robotics, spacecraft dynamics and nano technology.Read moreRead less
Mathematics and computing for integrated stockyard-centric management of mining supply chains. Blended mineral products, such as coal and iron ore, make a strong contribution to Australia's economy. Blending occurs in stockpiles, so to realise product value, stockyard and supply chain operational plans must align with blend targets. This project will provide new mathematical and computational planning tools to maximise this value.