Substance abuse is a significant social and economic burden upon Australian societies and on societies around the world. Treatment remains problematic due to the multi-layer nature of the disease, difficulties with treatment compliance and less than ideal treatment regimes. The present study aims to improve treatments for alcohol and drug abuse using pre-clinical models to identify and characterize a new brain system implicated in drug-seeking.
High Penetrance Deleterious Mutations In Blinding Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$1,345,055.00
Summary
This project aims to identify the genes most commonly mutated in individuals with advanced glaucoma. Identification of such genes will lead to improved understanding of glaucoma pathogenesis, a better ability to predict risk, and the identification of drug targets for novel therapies.
Advanced Computational and Analytic Studies in Lattice Statistical Mechanics and Applications. Lattice Statistical Mechanics is one of the current success stories of Australian Science with a significant international presence. The applicants represent a centre of excellence, particularly in the area of combining computational and analytic studies for maximum scientific benefit. The programme of research maximises Australia's investment in this human resource by focussing on an integrated set of ....Advanced Computational and Analytic Studies in Lattice Statistical Mechanics and Applications. Lattice Statistical Mechanics is one of the current success stories of Australian Science with a significant international presence. The applicants represent a centre of excellence, particularly in the area of combining computational and analytic studies for maximum scientific benefit. The programme of research maximises Australia's investment in this human resource by focussing on an integrated set of projects comprising a diverse and innovative group of applications in areas such as polymer science, DNA denaturation, combinatorics and the study of traffic flows. The underlying theme is always the utility of lattice statistical mechanics in 21st century science.Read moreRead less
Key combinatorial problems in lattice statistical mechanics. The enumeration of lattice animals is a famous open problem in combinatorics. These discrete structures also underpin our understanding of many physical phenomena, including polymer collapse and percolation in random media, through the integral part they play in many models in statistical mechanics and theoretical chemistry.
The project aims to answer some key open problems in this area using exact and numerical techniques. We expe ....Key combinatorial problems in lattice statistical mechanics. The enumeration of lattice animals is a famous open problem in combinatorics. These discrete structures also underpin our understanding of many physical phenomena, including polymer collapse and percolation in random media, through the integral part they play in many models in statistical mechanics and theoretical chemistry.
The project aims to answer some key open problems in this area using exact and numerical techniques. We expect that this will lead to proofs of the insolvability of certain problems, new exact solutions of others, and a greater understanding of the effect of topology and geometry on the behaviour of these models.Read moreRead less
Salt (sodium) is an essential electrolyte. Our convincing and complementary findings provide compelling evidence for a link between evolutionarily ancient “instincts” and substance abuse. This proposal is translational, including studies in opiate dependent humans. Our studies will establish how and where in the brain endogenous opioids are implicated in the gratification of salt appetite, how salt appetite is altered in opiate dependency and if salt appetite recovers following opiate withdrawal
Exact dynamics of the asymmetric exclusion process with boundaries. This project offers an opportunity for a postgraduate student to participate in world-class research. It further strengthens collaborative ties with the renowned department of theoretical physics at Oxford University. The outcomes of this project are expected to provide valuable fundamental information for any applied science in which transport plays a crucial role.
Hecke algebras and hidden symmetries in quantum spin chains. This project further strenghtens collaborative ties with Prof. Rittenberg who is a leading figure in statistical mechanics. Rittenberg is Scientific Director of one of the best journals, and has been instrumental in advocating and advancing Australia's influence in the field. All this on top of his original scientific input which we have become used to in the past years.
Theory and Applications of Hypergeometric Series. Techniques based on hypergeometric series lie at the heart of an exciting and rapidly developing class of mathematical methods, with applications to many areas of science and engineering, such as computer science, statistics, physics, chemistry and biology.
In the past decades Australia has been at the forefront of important developments in the field, and this proposal serves to further strengthen the country's leading reputation.
Many of th ....Theory and Applications of Hypergeometric Series. Techniques based on hypergeometric series lie at the heart of an exciting and rapidly developing class of mathematical methods, with applications to many areas of science and engineering, such as computer science, statistics, physics, chemistry and biology.
In the past decades Australia has been at the forefront of important developments in the field, and this proposal serves to further strengthen the country's leading reputation.
Many of the modern methods in the theory require expertise in mathematics as well as a high level of programming skills. This combination provides a unique training ground for higher degree students aiming at careers in financial mathematics, weather/climate forecasting and internet security.
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Conformal invariance and stationary states. Universal properties in nonequilibrium processes, such as scaling of space and time, suggest the existence of a fundamental, model independent theory describing such phenomena. An analogous theory for equilibrium phenomena exists, namely conformal field theory, and is extremely important for our understanding. Using recent insights this project aims at formulating such a theory for universal nonequilibrium behaviour.
A synthesis of random matrix theory for applications in mathematics, physics and engineering. Random matrix theory, matrix theory where the elements are random, or the matrix chosen from an ensemble, is driven by its ever expanding range of applications, and the richness of the mathematics being uncovered. These applications include topics of acknowledged modern day importance, for example quantum information theory, wireless communication, data analysis, signal processing and the study of algor ....A synthesis of random matrix theory for applications in mathematics, physics and engineering. Random matrix theory, matrix theory where the elements are random, or the matrix chosen from an ensemble, is driven by its ever expanding range of applications, and the richness of the mathematics being uncovered. These applications include topics of acknowledged modern day importance, for example quantum information theory, wireless communication, data analysis, signal processing and the study of algorithms. Buoyed by promising preliminary investigations, this project aims to draw together seemingly disparate techniques to tackle problems from such topics. In addition to providing solutions to these problems, these methods are expected to provide inspiration for fellow researchers.Read moreRead less