High Penetrance Deleterious Mutations In Blinding Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$1,345,055.00
Summary
This project aims to identify the genes most commonly mutated in individuals with advanced glaucoma. Identification of such genes will lead to improved understanding of glaucoma pathogenesis, a better ability to predict risk, and the identification of drug targets for novel therapies.
The stability of unsteady fluid flows in channels and pipes. The main benefit from this project will be a better theoretical understanding of the stability properties of unsteady fluid flows. The theoretical results obtained would help guide future experimental
investigations into the paths to turbulence in unsteady flows and would be a basis for future research in the increasingly important area of flow stability control. The project will also provide advanced training and skills transfer in a ....The stability of unsteady fluid flows in channels and pipes. The main benefit from this project will be a better theoretical understanding of the stability properties of unsteady fluid flows. The theoretical results obtained would help guide future experimental
investigations into the paths to turbulence in unsteady flows and would be a basis for future research in the increasingly important area of flow stability control. The project will also provide advanced training and skills transfer in an important area of fluid mechanics research.
Read moreRead less
Effects Of Latrepirdine On Beta Amyloid Clearance, Aggregation And Neurodegeneration In Alzheimer�s Disease
Funder
National Health and Medical Research Council
Funding Amount
$512,647.00
Summary
Alzheimer's disease (AD) is becoming more common with our growing aged population and currently no treatment exists that halts disease progress. The increasing health costs of AD underscore the need for development of any treatment that will slow or halt AD pathogenesis. By understanding the mechanisms of action of a drug [latrepirdine] that has recently shown some promise in phase II clinical trials, related drugs that are more specific and potent will be developed.
Special Research Initiatives - Grant ID: SR0354727
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Mathematics for Government, Industry and Community -- The *Magic* Network. The *Magic* network will promote the use of mathematics by government, industry and community to analyse real problems and implement practical solutions. It will connect the most promising young Australian mathematicians to experienced researchers with strong research teams linked directly to the broader community. Our program will demand research excellence, emphasise a sustainable society, support outstanding young mat ....Mathematics for Government, Industry and Community -- The *Magic* Network. The *Magic* network will promote the use of mathematics by government, industry and community to analyse real problems and implement practical solutions. It will connect the most promising young Australian mathematicians to experienced researchers with strong research teams linked directly to the broader community. Our program will demand research excellence, emphasise a sustainable society, support outstanding young mathematicians and create opportunities for promising postgraduate students. We will offer scholarships for professional development and fund research visits and exchanges. *Magic* will provide tangible incentives for young Australian mathematicians and a new generation of researchers and research leaders.Read moreRead less
The Effect Of Selected Nutraceuticals On Brain Blood Vessels And Memory.
Funder
National Health and Medical Research Council
Funding Amount
$445,206.00
Summary
The human brain receives 1000L of blood per day, distributed through minute vessels called capillaries. The integrity and function of brain capillaries is compromised with aging and this may contribute to memory disturbances. Our laboratory has identified several naturally occurring compounds that prevent age-associated defects of brain capillaries. The primary aim of this project is to explore if these agents are beneficial for restoring brain capillary function and memory.
ARC Complex Open Systems Research Network. Complexity is the common frontier in the physical, biological and social sciences. This Network will link specialists in all three sciences through five generic conceptual and mathematical theme activities. It will promote research into how subsystems self-organise into new emergent structures when assembled into an open, non-equilibrium system. Outcomes will include new technologies and software tools and deeper understanding of fundamental questions i ....ARC Complex Open Systems Research Network. Complexity is the common frontier in the physical, biological and social sciences. This Network will link specialists in all three sciences through five generic conceptual and mathematical theme activities. It will promote research into how subsystems self-organise into new emergent structures when assembled into an open, non-equilibrium system. Outcomes will include new technologies and software tools and deeper understanding of fundamental questions in science. An essential function of the network will be introducing researchers end users to new tools and broadening the horizons of graduate students.Read moreRead less
Quantum and Geometric Aspects of Gauge Theories, Supergravity and String Theory. A central problem of modern high-energy physics is the unification of gravity with the other fundamental interactions that is consistent at the quantum level. Led by a team of internationally recognized experts, this project will yield breakthroughs in supergravity and string theory - crucial ingredients of current approaches to unification. As well as putting Australia at the forefront of this mainstream activity, ....Quantum and Geometric Aspects of Gauge Theories, Supergravity and String Theory. A central problem of modern high-energy physics is the unification of gravity with the other fundamental interactions that is consistent at the quantum level. Led by a team of internationally recognized experts, this project will yield breakthroughs in supergravity and string theory - crucial ingredients of current approaches to unification. As well as putting Australia at the forefront of this mainstream activity, a fertile environment will be provided for the training of graduate students. They will be ideally placed to lead Australia's involvement in the revolution sparked by the expected experimental confirmation of supersymmetry with the Large Hadron Collider. Read moreRead less
Progress in Supersymmetry and Supergravity: Continuing Einstein's Legacy. 2005 is the International Year of Physics in recognition of Einstein's revolutionary contributions. His unfinished quest for a unified description of Nature has become the hottest topic in modern physics. Led by a team of internationally recognized experts, this project will yield breakthroughs in supersymmetry and supergravity - crucial ingredients of current approaches to unification. As well as putting Australia at the ....Progress in Supersymmetry and Supergravity: Continuing Einstein's Legacy. 2005 is the International Year of Physics in recognition of Einstein's revolutionary contributions. His unfinished quest for a unified description of Nature has become the hottest topic in modern physics. Led by a team of internationally recognized experts, this project will yield breakthroughs in supersymmetry and supergravity - crucial ingredients of current approaches to unification. As well as putting Australia at the forefront of this mainstream activity, a fertile environment will be provided for the training of graduate students. They will be ideally placed to lead Australia's involvement in the revolution sparked by the expected experimental confirmation of supersymmetry with the next generation of particle accelerators.Read moreRead less
Low Energy Effective Actions in Supersymmetric Gauge Theories. The quest for a unified quantum theory of all the fundamental interactions of Nature, including gravity, is a major goal of modern physics. Superstring theory is at present the only plausible candidate. This theory makes nontrivial predictions (non-renormalization theorems) about the low energy structure of certain supersymmetric gauge theories (the Standard Model of particle physics is a special gauge theory). This project will deve ....Low Energy Effective Actions in Supersymmetric Gauge Theories. The quest for a unified quantum theory of all the fundamental interactions of Nature, including gravity, is a major goal of modern physics. Superstring theory is at present the only plausible candidate. This theory makes nontrivial predictions (non-renormalization theorems) about the low energy structure of certain supersymmetric gauge theories (the Standard Model of particle physics is a special gauge theory). This project will develop new tools for the computation of low energy effective actions, which will then be used for a detailed analysis of the non-renormalization theorems governing the low energy dynamics of supersymmetric gauge theories. This research is at the forefront of modern particle physics.Read moreRead less
Efficient Computational Methods for Constrained Path Problems. We consider a class of path design problems which arise when an object needs to traverse between two points through a specified region. The region may be a continuous space or the path may be restricted to the edges of a network. The path must optimise a prescribed criterion such
as risk, reliability or cost and satisfy a number of constraints.
Problems of this type readily arise in the defence, transport and
communication i ....Efficient Computational Methods for Constrained Path Problems. We consider a class of path design problems which arise when an object needs to traverse between two points through a specified region. The region may be a continuous space or the path may be restricted to the edges of a network. The path must optimise a prescribed criterion such
as risk, reliability or cost and satisfy a number of constraints.
Problems of this type readily arise in the defence, transport and
communication industries. In addition to efficient solution methods
for these problems the project will produce computational tools for
a wide range of related network routing problems.Read moreRead less