Cancer Imaging And Targeted Radiation Therapy: From Discovery To Clinical Practice
Funder
National Health and Medical Research Council
Funding Amount
$2,114,215.00
Summary
This program will create a new pipeline of cancer imaging and targeted radiotherapy medical devices, translating discoveries to new first-in-world clinical trials and engaging with industry to see these innovations used in broad clinical practice. The research is applicable to all major cancer types and radiation therapy is essential for cancer cure and symptom control for half of all cancer patients, success means a global real-world impact on the lives of millions of cancer patients.
Optimising Treatment And Prevention Strategies To Accelerate Malaria Elimination
Funder
National Health and Medical Research Council
Funding Amount
$2,163,220.00
Summary
Elimination of malaria requires the assessment of interventions that not only treat individual infections successfully but also prevent disease at a population level. My proposal brings together data science approaches and mathematical modelling to develop new methods to assess antimalarial treatments and radical population interventions, and identify markers of drug resistance, accelerating malaria elimination efforts and building capacity in this emerging cross-disciplinary field.
Mapping Neurodevelopmental Disorders In A Zebrafish Model
Funder
National Health and Medical Research Council
Funding Amount
$2,760,520.00
Summary
The way in which the brain develops differently in neurodevelopmental disorders such as autism is hard to reveal in humans, but can be addressed in a zebrafish model. Using cutting-edge imaging and computational techniques, this project will investigate how neural representations of the world develop differently between normal zebrafish and zebrafish mutant for a gene that causes autism. This will provide new insights into the mechanisms of altered circuit development in autism.
Deciphering The Dynamic Neural Basis Of Cognition And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$1,287,350.00
Summary
Understanding the way that the human brain works is an immense challenge, but it is one that is within our reach. My plan is to unlock the untapped potential of human brain imaging using methods from network science, physics and computational modelling. The project will create working models of the brain that we can use to test hypotheses about how the brain works at the systems level. This will allow us predict how the brain begins to deteriorate in dementia and pave the way for new treatments.